Psoriasis Market to Exhibit Growth at a CAGR of 1.7% During the Forecast Period (2025-2034), Owing to Continuous Innovation in Biologic Therapies and Approval of Oral Small Molecules | DelveInsight
The psoriasis market is experiencing steady growth, driven by rising disease prevalence, improved diagnosis rates, and greater patient access to advanced therapies. The shift from conventional systemic treatments to high-efficacy biologics and targeted oral agents has significantly expanded market value. Additionally, the launch of emerging therapies such as zasocitinib (Takeda/Nimbus Therapeutics), icotrokinra (JNJ-77242113 [Johnson & Johnson Innovative Medicine and Protagonist Therapeutics]), piclidenoson (CF101 [Can-Fite BioPharma]), ESK-001 (Alumis), SFA-002 (SFA Therapeutics), and others further boost the market.
LAS VEGAS, Jan. 7, 2026 /PRNewswire/ -- DelveInsight's Psoriasis Market Insights report includes a comprehensive understanding of current treatment practices, psoriasis emerging drugs, market share of individual therapies, and current and forecasted market size from 2020 to 2034, segmented into leading markets [the United States, the EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan].
Psoriasis Market Summary
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Key Factors Driving the Growth of the Psoriasis Market
Rising Psoriasis Disease Prevalence
The global prevalence of psoriasis is increasing, with approximately 125 million people affected worldwide. The total number of diagnosed prevalent psoriasis cases in the 7MM was 16 million in 2024. These cases are expected to increase during the forecast period (2025−2034), driven by rising awareness following the launch of emerging therapies, a growing geriatric population, and advancements in diagnostic approaches, particularly in pathophysiology and biomarker data.
Advancements in Biologic Psoriasis Therapies
Innovations in biologic treatments, Tumor necrosis factor-alpha (TNF-α) inhibitors (including ENBREL, REMICADE, and HUMIRA), IL-23 inhibitors (like TREMFYA, SKYRIZI, and ILUMYA), IL-17 inhibitors (such as COSENTYX, TALTZ, and SILIQ ), and others are revolutionizing psoriasis care.
Rising Psoriasis Clinical Trial Landscape
The emerging landscape holds a diverse range of therapeutic alternatives for psoriasis treatment, including zasocitinib (Takeda/Nimbus Therapeutics), icotrokinra (JNJ-77242113 [Johnson & Johnson Innovative Medicine and Protagonist Therapeutics]), piclidenoson (CF101 [Can-Fite BioPharma]), ESK-001 (Alumis), SFA-002 (SFA Therapeutics), and others. The expected launch of these therapies is expected to further positively impact the psoriasis market.
Emerging Oral Psoriasis Therapies in Development
Current emerging psoriasis drugs, including zasocitinib, ESK-001, piclidenoson, SFA-002, and icotrokinra, are mainly oral therapies, offering a potent alternative to injectable biologics and meeting patients' demand for convenience without compromising efficacy.
Promise of Takeda/Nimbus Therapeutics' Zasocitinib
Zasocitinib, a TYK2 inhibitor in Phase III trials, shows promise with its high efficacy and favorable safety profile compared to traditional JAK inhibitors. With up to one-third of patients achieving complete clearance, it represents a new frontier in oral psoriasis treatment.
Psoriasis Market Analysis
The psoriasis treatment landscape is evolving rapidly, driven by the steady introduction of innovative therapies. These newer agents deliver impressive clinical efficacy, each distinguished by specific mechanisms and safety profiles, making meaningful disease control attainable for nearly all patients who pursue treatment.
Tumor necrosis factor-alpha (TNF-α) inhibitors, such as ENBREL, REMICADE, and HUMIRA, were the earliest biologics approved for moderate-to-severe psoriasis. CIMZIA marked a strategic advancement as the first FDA-approved Fc-free biologic for adults with moderate-to-severe plaque psoriasis. Despite their effectiveness, TNF-α inhibitors have been linked to paradoxical reactions, including the onset of new psoriasis or exacerbation of previously inactive disease.
IL-23 inhibitors, including TREMFYA, SKYRIZI, and ILUMYA, are recognized for their favorable tolerability and well-established long-term safety. In contrast, IL-17 inhibitors such as COSENTYX, TALTZ, and SILIQ have shown more rapid skin clearance compared with IL-23 therapies.
Clinical evidence indicates that patients with plaque psoriasis who transition to SKYRIZI after insufficient response to COSENTYX or ILUMYA experience meaningful reductions in disease severity, improved symptom control, and enhanced quality of life.
Looking ahead, Amgen's leading psoriasis therapies, ENBREL and OTEZLA, are expected to face pressure from the Inflation Reduction Act, with Medicare price negotiations beginning for ENBREL in 2026 and for OTEZLA in 2027.
Psoriasis Competitive Landscape
The emerging landscape is vast and diverse. The major therapies anticipated to enter and compete, such as ESK-001 and zasocitinib (TYK2 inhibitors). Companies like Can-Fite BioPharma (piclidenoson; A3 Adenosine Receptor [A3AR] agonist) and SFA Therapeutics (SFA-002; TNF-α, IL-23, IL-10, IL-12, IL-17, and IFN-γ inhibitor) are conducting late-stage trials for the treatment of psoriasis. With unique MoAs, these therapies hold an opportunity to stand out.
Takeda's TAK-279 is a late-stage, orally administered, highly selective allosteric inhibitor of TYK2, exhibiting roughly 1.3 million-fold greater selectivity for TYK2 over JAK1. In a Phase IIb trial involving patients with moderate-to-severe psoriasis, significantly higher proportions of patients treated with TAK-279 achieved PASI 75, PASI 90, and PASI 100 at doses of 5 mg, 15 mg, and 30 mg versus placebo at Week 12. The program has advanced into Phase III development, with a head-to-head trial against deucravacitinib expected to begin in 2025. According to Takeda's development roadmap, regulatory submission for zasocitinib is targeted for fiscal year 2026.
SFA Therapeutics' SFA-002 is a novel oral immunomodulatory agent being developed for autoimmune disorders, with an initial focus on mild-to-moderate chronic plaque psoriasis. Rather than inhibiting a single immune pathway, SFA-002 exerts a broad immunoregulatory effect by acting on multiple cellular mechanisms. It reduces the production of several key pro-inflammatory cytokines, including TNF-α, IL-23, IL-12, IL-17, IL-10, and IFN-γ, while rebalancing the underlying autoimmune response.
Johnson & Johnson Innovative Medicine and Protagonist Therapeutics' Icotrokinra represents the first targeted oral peptide engineered to selectively inhibit the IL-23 receptor, a central driver of inflammation in moderate-to-severe plaque psoriasis, with potential applicability across other IL-23-mediated conditions. The compound binds the IL-23 receptor with single-digit picomolar affinity and demonstrates strong, highly selective suppression of IL-23 signaling in human T cells.
Alumis' ESK-001 is a next-generation investigational TYK2 inhibitor designed to address immune dysregulation across multiple inflammatory diseases driven by cytokines such as IL-23, IL-17, and type I interferons. Its selective mechanism aims to achieve robust pathway inhibition while minimizing off-target interactions and associated adverse effects.
The anticipated launch of these emerging therapies are poised to transform the psoriasis market landscape in the coming years. As these cutting-edge therapies continue to mature and gain regulatory approval, they are expected to reshape the psoriasis market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth.
Discover more about the psoriasis drugs @ Psoriasis Drugs Market
Recent Developments in the Psoriasis Market
What is Psoriasis?
Psoriasis is a chronic, immune-mediated inflammatory skin disorder characterized by the rapid buildup of skin cells, leading to thick, red, scaly patches that can be itchy, painful, or both. It occurs when the immune system mistakenly accelerates the life cycle of skin cells, causing them to accumulate on the skin's surface rather than shedding as usual. Psoriasis most commonly affects the elbows, knees, scalp, and lower back, but it can appear anywhere on the body. The condition is not contagious and tends to follow a relapsing-remitting course, with periods of flare-ups and remission. In addition to skin involvement, psoriasis may be associated with systemic inflammation and comorbidities, including psoriatic arthritis, cardiovascular disease, and metabolic disorders.
Psoriasis Epidemiology Segmentation
The psoriasis epidemiology section provides insights into the historical and current psoriasis patient pool and forecasted trends for the leading markets. Psoriasis is predominantly observed in adults, accounting for approximately 97% of all cases in the 7MM.
The psoriasis treatment market report proffers epidemiological analysis for the study period 2020–2034 in the leading markets, segmented into:
Psoriasis Market Report Metrics
Details
Study Period
2020–2034
Coverage
7MM [The United States, the EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan].
Psoriasis Market CAGR
1.7 %
Psoriasis Market Size in 2024
USD 33.4 Billion
Key Psoriasis Companies
Takeda, Nimbus Therapeutics, Johnson & Johnson Innovative Medicine, Protagonist Therapeutics, Can-Fite BioPharma, Alumis, SFA Therapeutics, Novartis, Sun Pharmaceutical, Dr Reddy's, Promius Pharma, Encore Dermatology, AbbVie, AstraZeneca, Bausch Health, Kyowa Kirin, LEO Pharma, UCB, LEO Pharma, Boehringer Ingelheim, Organon Pharmaceuticals, Eli Lilly and Company, Bristol Myers Squibb, Arcutis Biotherapeutics, Mayne Pharma, Bausch Health, MC2 Therapeutics, Almirall, and others
Key Psoriasis Therapies
Zasocitinib (TAK-279), Icotrokinra (JNJ-77242113), Piclidenoson (CF101), ESK-001, SFA-002, COSENTYX, ILUMYA/ILUMETRI, BRYHALI, SERNIVO, SKYRIZI, TREMFYA, SILIQ/KYNTHEUM/LUMICEF, CIMZIA, ENSTILAR, SPEVIGO, VTAMA, TALTZ, SOTYKTU, ZORYVE, LEXETTE, DUOBRII, WYNZORA Cream, and others
Scope of the Psoriasis Market Report
Download the report to understand what is the latest research on psoriasis @ New Psoriasis Medication
Table of Contents
1
Psoriasis Market Key Insights
2
Psoriasis Market Report Introduction
3
Executive Summary
4
Key Events
5
Epidemiology and Market Forecast Methodology
6
Psoriasis Market Overview at a Glance
6.1
Market Share (%) Distribution by Therapies of Psoriasis in 2020
6.2
Market Share (%) Distribution by Therapies of Psoriasis in 2034
7
Disease Background and Overview
7.1
Introduction
7.2
Causes and Risk Factors
7.3
Locations
7.4
Types of Psoriasis
7.5
Psoriasis Pathophysiology
7.6
Psoriasis Diagnosis
7.7
Treatment Guidelines
8
Epidemiology and Patient Population of 7MM
8.1
Key Findings
8.2
Assumption and Rationale
8.3
Total Diagnosed Prevalent Cases of Psoriasis in the 7MM
8.4
The United States
8.4.1
Total Diagnosed Prevalent Cases of Psoriasis in the US
8.4.2
Type-specific Diagnosed Prevalent Cases of Psoriasis in the US
8.4.3
Location-specific Diagnosed Prevalent Cases of Psoriasis in the US
8.4.4
Severity-specific Diagnosed Prevalent Cases of Psoriasis in the US
8.5
EU4 and the UK
8.6
Japan
9
Patient Journey of Psoriasis
10
Marketed Psoriasis Therapies
10.1
Key Cross of Marketed Therapies
10.2
BIMZELX (bimekizumab): UCB Pharma
10.2.1
Product Description
10.2.2
Regulatory Milestones
10.2.3
Other Developmental Activities
10.2.4
Clinical Development
10.2.4.1
Clinical Trial Information
10.2.5
Safety and Efficacy
10.2.6
Analyst View
10.3
COSENTYX (secukinumab): Novartis
10.4
ILUMYA/ILUMETRI (tildrakizumab-asmn): Sun Pharmaceutical/Almirall
10.5
BRYHALI (halobetasol propionate): Bausch Health
10.6
SERNIVO (betamethasone dipropionate): Dr Reddy's/Promius Pharma/Encore Dermatology
10.7
SKYRIZI (risankizumab-rzaa): AbbVie and Boehringer Ingelheim
10.8
TREMFYA (guselkumab): Johnson & Johnson
10.9
SILIQ/KYNTHEUM/LUMICEF (brodalumab): AstraZeneca/Bausch Health/Kyowa Kirin/LEO Pharma
10.10
CIMZIA (certolizumab pegol): UCB
10.11
ENSTILAR (calcipotriene and betamethasone dipropionate): LEO Pharma
10.12
SPEVIGO (spesolimab-sbzo): Boehringer Ingelheim
10.13
VTAMA (tapinarof): Organon Pharmaceuticals
10.14
TALTZ (ixekizumab): Eli Lilly and Company
10.15
SOTYKTU (deucravacitinib): Bristol Myers Squibb
10.16
ZORYVE (roflumilast): Arcutis Biotherapeutics
10.17
LEXETTE (Halobetasol Propionate Foam 0.05%): Mayne Pharma
10.18
DUOBRII (Halobetasol Propionate and Tazarotene Lotion): Bausch Health
10.19
WYNZORA Cream (calcipotriene and betamethasone dipropionate): MC2 Therapeutics/Almirall
11
Emerging Psoriasis Drugs
11.1
Key Cross Competition
11.2
Zasocitinib (TAK-279): Takeda/Nimbus Therapeutics
11.2.1
Product Description
11.2.2
Other Development Activity
11.2.3
Clinical Development
11.2.3.1
Clinical Trial Information
11.2.4
Safety and Efficacy
11.2.5
Analyst View
11.3
Icotrokinra (JNJ-77242113): Johnson & Johnson Innovative Medicine and Protagonist Therapeutics
11.4
Piclidenoson (CF101): Can-Fite BioPharma
11.5
ESK-001: Alumis
11.6
SFA-002: SFA Therapeutics
12
Psoriasis Market: 7MM Analysis
12.1
Key Findings
12.2
Psoriasis Market Outlook
12.3
Key Psoriasis Market Forecast Assumptions
12.4
Conjoint Analysis
12.5
Total Market Size of Psoriasis in the 7MM
12.6
Market Size of Psoriasis by Therapies in 7MM
12.7
United States Psoriasis Market Size
12.7.1
Total Market Size of Psoriasis in the United States
12.7.2
Market Size of Psoriasis by Therapies in the United States
12.8
EU4 and the United Kingdom Psoriasis Market Size
12.9
Japan Psoriasis Market Size
13
Psoriasis Market Unmet Needs
14
Psoriasis Market SWOT Analysis
15
KOL Views on Psoriasis
16
Psoriasis Market Access and Reimbursement
16.1
The United States
16.2
EU4 and the UK
16.3
Japan
16.4
Market Access and Reimbursement of Psoriasis
17
Bibliography
18
Psoriasis Market Report Methodology
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