Form 8-K

8-K — BICYCLE THERAPEUTICS PLC

Accession: 0001104659-26-075451

Filed: 2026-06-18

Period: 2026-06-17

CIK: 0001761612

SIC: 2834 (PHARMACEUTICAL PREPARATIONS)

Item: Submission of Matters to a Vote of Security Holders

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section

13 or 15(d) of the Securities Exchange Act of 1934

June 17, 2026

Date of Report (Date of earliest event reported)

Bicycle

Therapeutics plc

(Exact name of registrant as specified in its

charter)

England

and Wales

001-38916

Not

applicable

(State or other jurisdiction

of incorporation)

(Commission

File Number)

(IRS Employer

Identification No.)

Blocks

A & B, Portway Building,

Granta

Park Great Abington, Cambridge

United Kingdom

CB21

6GS

(Address of principal

executive offices)

(Zip Code)

Registrant’s telephone number, including area code: +44

1223 261503

Check the appropriate box below if the Form 8-K

filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

¨ Written

communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

¨ Soliciting

material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

¨ Pre-commencement

communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

¨ Pre-commencement

communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b)

of the Act:

Title

of each class

Trading

Symbol (s)

Name

of each exchange on which registered

Ordinary

shares, nominal value £0.01 per share

n/a

The

Nasdaq

Stock Market LLC*

American

Depositary Shares, each representing one ordinary share, nominal value £0.01 per share

BCYC

The

Nasdaq

Stock Market LLC

* Not

for trading, but only in connection with the listing of the American Depositary Shares on The Nasdaq Stock Market LLC.

Indicate

by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405

of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ¨

If an emerging

growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any

new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨

Item 5.07 Submission of Matters to a Vote of Security Holders

Bicycle Therapeutics plc (the “Company”)

held its annual general meeting of shareholders (the “AGM”) on June 17, 2026. Each of the proposals set forth below were voted

on and duly passed on a poll at the AGM. Detailed descriptions of these proposals and of the voting procedures applied at the AGM are

contained in the Company’s definitive proxy statement on Schedule 14A filed with the Securities and Exchange Commission on April

22, 2026.

There were 49,696,908 ordinary shares of the Company

represented in person or by proxy at the AGM, constituting approximately 98.64% of the issued and outstanding ordinary shares on June

17, 2026. Proxy appointments which gave the Chairman of the meeting discretion have been included in the “For” total. In accordance

with the terms of the deposit agreement by and among the Company, Citibank, N.A., as depositary, and holders and beneficial owners of

American Depositary Shares (“ADSs”) dated May 28, 2019, holders of ADSs who did not provide the depositary bank with voting

instructions on or before the specified deadline were deemed to have instructed the depositary to give a discretionary proxy to a person

designated by the Company to vote the underlying ordinary shares at the AGM and the voting results below reflect that designation. A vote

withheld/abstain is not a vote in law and is not counted in the calculation of votes for or against a resolution.

Ordinary Resolutions

Proposal 1 – To re-elect as a director

Felix Baker

For

Against

Vote Withheld/Abstain

46,171,302

3,364,113

161,493

Proposal 2 – To re-elect as a director

Hervé Hoppenot

For

Against

Vote Withheld/Abstain

49,284,459

250,669

161,780

Proposal 3 – To approve, on an advisory

basis, the compensation of the Company’s named executive officers, as disclosed in the Company’s definitive proxy statement

For

Against

Vote Withheld/Abstain

48,748,743

785,032

163,133

Proposal 4 – To ratify the appointment

of PricewaterhouseCoopers LLP, a limited liability partnership organized under the laws of England, as the Company’s independent

registered public accounting firm for the year ending December 31, 2026

For

Against

Vote Withheld/Abstain

49,445,128

232,627

19,153

Proposal 5 – To re-appoint PricewaterhouseCoopers

LLP, a limited liability partnership organized under the laws of England, as the Company’s U.K. statutory auditors, to hold office

until the conclusion of the next annual general meeting of shareholders

For

Against

Vote Withheld/Abstain

49,441,337

235,008

20,563

Proposal 6 – To authorize the Audit Committee

of the Company’s Board of Directors to determine the Company’s U.K. statutory auditors’ remuneration

for the year ending December 31, 2026

For

Against

Vote Withheld/Abstain

49,493,240

47,269

156,399

Proposal 7 – To receive and adopt

the Company’s U.K. statutory annual accounts and reports for the year ended December 31, 2025.

For

Against

Vote Withheld/Abstain

49,138,590

553,781

4,537

Proposal 8 – To approve the directors’

remuneration report for the year ended December 31, 2025, which report is set forth in the Company’s definitive proxy statement

(excluding the directors’ remuneration policy)

For

Against

Vote Withheld/Abstain

48,741,517

792,394

162,997

Proposal 9 – To approve the

directors’ remuneration policy, which policy is set forth in the Company’s definitive proxy statement, and which will take

effect immediately after the end of the AGM

For

Against

Vote Withheld/Abstain

48,238,031

1,293,722

165,155

SIGNATURES

Pursuant to the requirements

of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto

duly authorized.

Date: June 18, 2026

BICYCLE THERAPEUTICS PLC

By:

/s/

Travis Thompson

Name:

Travis Thompson

Title:

Chief Financial Officer

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