Form 8-K

8-K — Alto Neuroscience, Inc.

Accession: 0001104659-26-082875

Filed: 2026-07-13

Period: 2026-07-13

CIK: 0001999480

SIC: 2834 (PHARMACEUTICAL PREPARATIONS)

Item: Results of Operations and Financial Condition

Item: Other Events

Documents

8-K — tm2620297d1_8k.htm (Primary)

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported):

July 13, 2026

ALTO NEUROSCIENCE, INC.

(Exact Name of Registrant as Specified in its

Charter)

Delaware

001-41944

83-4210124

(State or Other Jurisdiction

of Incorporation)

(Commission

File Number)

(IRS Employer

Identification No.)

650 Castro Street, Suite 450, Mountain View, CA

94041

(Address of principal executive offices)

(Zip Code)

Registrant’s telephone number, including

area code: (650) 200-0412

N/A

(Former name or former address, if changed since

last report)

Check the appropriate box below if the Form 8-K filing is intended

to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

Written communications pursuant

to Rule 425 under the Securities Act (17 CFR 230.425)

Soliciting material pursuant to Rule 14a-12 under

the Exchange Act (17 CFR 240.14a-12)

Pre-commencement communications pursuant to Rule 14d-2(b) under

the Exchange Act (17 CFR 240.14d-2(b))

Pre-commencement communications pursuant to Rule 13e-4(c) under

the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the

Act:

Title of each class

Trading

Symbol(s)

Name of each exchange

on which registered

Common Stock, $0.0001 par value per share

ANRO

New York Stock Exchange

Indicate by check mark whether the registrant

is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2

of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging

growth company x

an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying

with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨

Item 2.02. Results of Operations and Financial Condition.

The information disclosed under the heading “Cash,

Cash Equivalents and Restricted Cash as of June 30, 2026” under Item 8.01 of this Current Report on Form 8-K is incorporated

herein by reference and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as

amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed

incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set

forth by specific reference in such a filing.

Item 8.01 Other Events.

Cash, Cash Equivalents and Restricted Cash as of June 30, 2026

On July 13, 2026, Alto Neuroscience, Inc. (the

“Company”) announced that, based upon preliminary estimates and information available to the Company, it estimates

that its cash, cash equivalents and restricted cash were approximately $244.2 million as of June 30, 2026. This amount has not been audited,

reviewed, or compiled by the Company’s independent registered public accounting firm. The Company’s actual cash, cash equivalents

and restricted cash as of June 30, 2026 may differ from these amounts after it completes its comprehensive accounting procedures for the

quarter ended June 30, 2026, and any such differences may be material.

Pipeline Update

The Company intends to accelerate and expand the

clinical development of its most advanced program, ALTO-207, including to conduct an additional planned Phase 3 trial of ALTO-207 as monotherapy

for the treatment of treatment-resistant depression.

Forward-Looking Statements

This Current Report on Form 8-K contains forward-looking

statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as “anticipates,” “believes,”

“expects,” “intends,” “projects,” “plans,” and “future” or similar expressions

are intended to identify forward-looking statements. Forward-looking statements include statements concerning the Company’s clinical

development plans for ALTO-207, and other statements that are not historical fact. Forward-looking statements are based on management’s

current expectations and are subject to various risks and uncertainties that could cause actual results to differ materially and adversely

from those expressed or implied by such forward-looking statements. Accordingly, these forward-looking statements do not constitute guarantees

of future performance, and you are cautioned not to place undue reliance on these forward-looking statements. Risks regarding the Company’s

business are described in detail in its SEC filings, including in the Company’s Annual Report on Form 10-K for the year ended December

31, 2025 and other filings that the Company may make with the SEC, which are available on the SEC’s website at www.sec.gov. Additional

information will be made available in other filings that the Company makes from time to time with the SEC. These forward-looking statements

speak only as of the date hereof, and the Company disclaims any obligation to update these statements except as may be required by law.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934,

the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

ALTO NEUROSCIENCE, INC.

Dated: July 13, 2026

By:

/s/ Amit Etkin

Amit Etkin, M.D., Ph.D.

President and Chief Executive Officer

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