Form 8-K

8-K — Monopar Therapeutics

Accession: 0001437749-26-018896

Filed: 2026-05-29

Period: 2026-05-29

CIK: 0001645469

SIC: 2834 (PHARMACEUTICAL PREPARATIONS)

Item: Regulation FD Disclosure

Item: Financial Statements and Exhibits

Documents

8-K — mnpr20260529_8k.htm (Primary)

EX-99.1 — EXHIBIT 99.1 (ex_969880.htm)

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0001645469

2026-05-29

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): May 29, 2026

MONOPAR THERAPEUTICS INC.

(Exact name of registrant as specified in its charter)

Delaware

001-39070

32-0463781

(State or other jurisdiction

of incorporation)

(Commission

File Number)

(I.R.S. Employer

Identification No.)

1000 Skokie Blvd., Suite 350, Wilmette, IL

60091

(Address of principal executive offices)

(Zip Code)

(847) 388-0349

Registrant’s telephone number, including area code

N/A

(Former name or former address, if changed since last report)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class

Trading Symbol(s)

Name of each exchange on which registered

Common Stock, $0.001 par value

MNPR

The Nasdaq Stock Market LLC (Nasdaq Capital Market)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 7.01. Regulation FD Disclosure

On May 29, 2026, Monopar Therapeutics Inc. (“Monopar”) presented results from a Phase 2 study (NCT04422431) evaluating the effect of ALXN1840 (tiomolibdate choline) on liver pathology and clinical symptoms in patients with Wilson disease at the European Association for the Study of the Liver (“EASL”) International Liver Congress 2026.

The presentation is furnished as Exhibit 99.1 to this report and incorporated herein by reference.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.

Exhibit

No.

Description

99.1

Presentation dated May 29, 2026.

104

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SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Monopar Therapeutics Inc.

Date: May 29, 2026

By:

/s/ Quan Vu

Name:

Quan Vu

Title:

Chief Financial Officer

EX-99.1 — EXHIBIT 99.1

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Document And Entity Information

May 29, 2026

Document Information [Line Items]

Entity, Registrant Name

MONOPAR THERAPEUTICS INC.

Document, Type

8-K

Document, Period End Date

May 29, 2026

Entity, Incorporation, State or Country Code

Entity, File Number

001-39070

Entity, Tax Identification Number

32-0463781

Entity, Address, Address Line One

1000 Skokie Blvd.

Entity, Address, Address Line Two

Suite 350

Entity, Address, City or Town

Wilmette

Entity, Address, State or Province

Entity, Address, Postal Zip Code

60091

City Area Code

847

Local Phone Number

388-0349

Title of 12(b) Security

Common Stock

Trading Symbol

MNPR

Security Exchange Name

NASDAQ

Written Communications

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