Form 8-K

8-K — Alkermes plc.

Accession: 0001193125-26-205008

Filed: 2026-05-05

Period: 2026-05-05

CIK: 0001520262

SIC: 2834 (PHARMACEUTICAL PREPARATIONS)

Item: Results of Operations and Financial Condition

Item: Financial Statements and Exhibits

Documents

8-K — alks-20260505.htm (Primary)

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8-K

8-K (Primary)

Filename: alks-20260505.htm · Sequence: 1

8-K

0001520262falseAlkermes plc.00015202622026-05-052026-05-05

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

PURSUANT TO SECTION 13 OR 15(d) OF THE

SECURITIES EXCHANGE ACT OF 1934

Date of Report (Date of earliest event reported): May 5, 2026

ALKERMES PUBLIC LIMITED COMPANY

(Exact name of registrant as specified in its charter)

Ireland

001-35299

98-1007018

(State or other jurisdiction

(Commission

(IRS Employer

of incorporation)

File Number)

Identification No.)

Connaught House, 1 Burlington Road

Dublin 4, Ireland D04 C5Y6

(Address of principal executive offices)

Registrant's telephone number, including area code: + 353-1-772-8000

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

☐

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class

Trading Symbol(s)

Name of each exchange on which registered

Ordinary shares, $0.01 par value

ALKS

Nasdaq Global Select Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 2.02 Results of Operations and Financial Condition.

On May 5, 2026, Alkermes plc (the “Company”) announced financial results for the three months ended March 31, 2026 and updated certain financial expectations for the year ending December 31, 2026. Copies of the related press release and the investor presentation to be displayed during the Company’s conference call on May 5, 2026 discussing such financial results and expectations are furnished herewith as Exhibit 99.1 and Exhibit 99.2, respectively. This information, including Exhibits 99.1 and 99.2, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such a filing.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

EXHIBIT INDEX

Exhibit No.

Description

99.1

Press release issued by Alkermes plc on May 5, 2026 announcing financial results for the three months ended March 31, 2026 and updated financial expectations for the year ending December 31, 2026.

99.2

Investor presentation to be displayed by Alkermes plc on May 5, 2026.

104

Cover page interactive data file (embedded within the Inline XBRL document).

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

ALKERMES PLC

Date: May 5, 2026

By:

/s/ Joshua Reed

Joshua Reed

Senior Vice President, Chief Financial Officer (Principal Financial Officer)

EX-99.1

Filename: alks-ex99_1.htm · Sequence: 2

EX-99.1

Exhibit 99.1

Alkermes Contacts:

For Investors:

Sandy Coombs +1 781 609 6377

For Media:

Katie Joyce +1 781 249 8927

Alkermes plc Reports First Quarter 2026 Financial Results

— First Quarter Revenues of $392.9 Million; GAAP Net Loss of $66.5 Million and Adjusted EBITDA of $80.3 Million —

— Acquisition of Avadel Pharmaceuticals Completed in February 2026 —

— Alixorexton Brilliance Phase 3 Narcolepsy Clinical Program Initiated in Q1 2026 —

DUBLIN, May 5, 2026 — Alkermes plc (Nasdaq: ALKS) today reported financial results for the first quarter of 2026 and updated certain non-cash elements of its 2026 full year financial expectations in connection with the acquisition of Avadel Pharmaceuticals plc (Avadel), resulting in improved expectations for GAAP net loss and EBITDA.

“We delivered a strong quarter marked by solid financial and commercial execution, alongside meaningful strategic progress that positions Alkermes as an emerging leader in sleep medicine,” said Richard Pops, Chairman and Chief Executive Officer of Alkermes. “During the quarter, we successfully closed the acquisition of Avadel, strengthening our financial profile and accelerating our entry into the commercial sleep medicine market at scale. We are also rapidly advancing the alixorexton development program and recently initiated the phase 3 Brilliance studies to further characterize alixorexton’s differentiated profile and potential utility in both narcolepsy type 1 and type 2. The multi‑billion‑dollar market opportunity in narcolepsy and idiopathic hypersomnia represents a transformative opportunity for Alkermes. Taken together with the broad therapeutic potential across other neuropsychiatric disorders, orexin 2 receptor agonists represent one of the most exciting new therapeutic categories in neuroscience, and Alkermes is at the forefront of generating new clinical data and expanding our understanding of this neurocircuitry.”

Key Financial Highlights

Revenues

Three Months Ended

March 31,

(In millions)

2026

2025

Total Revenues

392.9

306.5

Total Proprietary Net Sales

338.1

244.5

VIVITROL®

112.4

101.0

ARISTADA®i

93.8

73.5

LYBALVI®

92.4

70.0

LUMRYZ®

39.5

—

Profitability

Three Months Ended

March 31,

(In millions)

2026

2025

GAAP Net (Loss) Income

(66.5)

22.5

EBITDA

(30.1)

22.8

Adjusted EBITDA

80.3

45.6

Revenue Highlights

Proprietary Product Revenues

•

LYBALVI revenues for the quarter were $92.4 million. Revenues and total prescriptions grew 32% and 21%, respectively, compared to the first quarter of 2025. During the quarter, the company recorded LYBALVI revenue of approximately $2 million related to gross-to-net favorability, primarily driven by favorable patient mix.

•

ARISTADAi revenues for the quarter were $93.8 million. During the quarter, the company recorded ARISTADA revenue of approximately $3.5 million related to gross-to-net favorability, primarily driven by favorable patient mix.

•

VIVITROL revenues for the quarter were $112.4 million. During the quarter, the company recorded VIVITROL revenue of approximately $9 million related to gross-to-net favorability, primarily driven by favorable patient mix.

•

LUMRYZ revenues for the quarter were $39.5 million, representing the period of Feb. 12, 2026 - March 31, 2026. Prior to the completion of the acquisition, Avadel recorded LUMRYZ net sales of approximately $33 million between Jan. 1, 2026 and Feb. 11, 2026.

Manufacturing & Royalty Revenues

•

VUMERITY® manufacturing and royalty revenues for the quarter were $27.3 million.

•

Royalty revenues from XEPLION®, INVEGA TRINZA®/TREVICTA® and INVEGA HAFYERA®/BYANNLI® for the quarter were $18.0 million.

Key Operating Expenses

Three Months Ended

March 31,

(In millions)

2026

GAAP

2026

Transaction Adjustments(1)

2026

Non-GAAP

Adjusted

2025

GAAP

Cost of Goods Sold

61.6

12.7

48.9

49.2

R&D Expense

103.3

8.1

95.3

71.8

SG&A Expense

264.6

55.2

209.4

171.7

(1)

Includes $20.2 million of share-based compensation expense related to the acceleration of vesting of equity awards for former Avadel employees which vested in full upon the closing of the transaction.

Balance Sheet

•

At March 31, 2026, the company recorded cash, cash equivalents, restricted cash and total investments of $538.2 million, compared to $1.32 billion at Dec. 31, 2025.

•

To finance the acquisition of Avadel, which closed in February 2026, the company used approximately $775 million of cash from its balance sheet and entered into term loans totaling $1.525 billion due in 2031.

Share Repurchase Program

•

During the first quarter of 2026, the company repurchased approximately 1 million of the company’s ordinary shares under the share repurchase program authorized in February 2024, at a total purchase price of approximately $28 million.

•

As of March 31, 2026, the company had approximately $172 million (exclusive of any fees, commissions or other related expenses) remaining under the program.

Financial Expectations for 2026

In connection with the purchase price accounting related to the acquisition of Avadel, the company is updating certain non-cash elements of its 2026 full year financial expectations, resulting in improved expectations for GAAP net loss and EBITDA. All line items are according to GAAP, except as otherwise noted.

(In millions)

Previous 2026 Expectations

(provided Feb. 25, 2026)

Updated 2026 Expectations

(provided May 5, 2026)

Total Revenues

$1,730 – $1,840

VIVITROL Net Sales

$460 – $480

LYBALVI Net Sales

$380 – $400

ARISTADAi Net Sales

$365 – $385

LUMRYZ Net Sales a

$315 – $335

Cost of Goods Sold b

$365 – $385

$320 – $340

R&D Expenses

$445 – $485

SG&A Expenses

$890 – $930

Amortization of Intangible Assets c

$95 – $105

$75 – $85

Net Interest Expense

$75 – $85

Net Tax Benefit

~$20

~$0

GAAP Net Loss d

($115) – ($135)

($70) – ($90)

EBITDA e

$60 – $90

$105 – $135

Adjusted EBITDA e

$370 – $410

The acquisition of Avadel closed on Feb. 12, 2026. LUMRYZ Net Sales expectations represents the period of Feb. 12, 2026 – Dec. 31, 2026.

In connection with the acquisition of Avadel, the company will record approximately $125 million of LUMRYZ inventory fair value step-up; the company expects that approximately $105 million of this amount will be expensed in 2026 as this inventory is sold.

In connection with the acquisition of Avadel, the company expects to record approximately $1.8 billion of intellectual property related to LUMRYZ, which will be amortized over an expected life of 14 years.

Expected 2026 weighted average basic share count of approximately 169.1 million shares outstanding and a weighted average diluted share count of approximately 172.8 million shares outstanding.

Non-GAAP measure.

Conference Call

Alkermes will host a conference call and webcast presentation with accompanying slides at 8:00 a.m. ET (1:00 p.m. BST) on Tuesday, May 5, 2026, to discuss these financial results and expectations and provide an update on the company. The webcast may be accessed on the Investors section of Alkermes’ website at www.alkermes.com. The conference call may be accessed by dialing +1 877 407 2988 for U.S. callers and +1 201 389 0923 for international callers. In addition, a replay of the conference call may be accessed by visiting Alkermes’ website.

About Alkermes plc

Alkermes plc, a mid-cap growth and value equity, is a global biopharmaceutical company that seeks to develop innovative medicines in the field of neuroscience. The company has a portfolio of proprietary commercial products for the treatment of alcohol dependence, opioid dependence, schizophrenia, bipolar I disorder and narcolepsy. Alkermes’ pipeline includes late-stage clinical candidates in development for narcolepsy and idiopathic hypersomnia, and orexin 2 receptor agonists in early clinical development for other neurological disorders, including attention-deficit hyperactivity disorder (ADHD) and fatigue associated with multiple sclerosis and Parkinson’s disease. Headquartered in Ireland, Alkermes also has a corporate office and research and development center in Massachusetts and a manufacturing facility in Ohio. For more information, please visit Alkermes’ website at www.alkermes.com.

Non-GAAP Financial Measures

This press release includes information about certain financial measures that are not prepared in accordance with generally accepted accounting principles in the U.S. (GAAP), including EBITDA and Adjusted EBITDA. These non-GAAP measures are not based on any standardized methodology prescribed by GAAP and are not necessarily comparable to similar measures presented by other companies.

EBITDA represents earnings before interest, tax, depreciation and amortization. Adjusted EBITDA excludes share-based compensation expense and non-recurring gains or losses in addition to the components of EBITDA from earnings.

The company’s management and board of directors utilize these non-GAAP financial measures to evaluate the company’s performance. The company provides these non-GAAP financial measures of the company’s performance to investors because management believes that these non-GAAP financial measures, when viewed with the company’s results under GAAP and the accompanying reconciliations, are useful in identifying underlying trends in ongoing operations. However, EBITDA and Adjusted EBITDA are not measures of financial performance under GAAP and, accordingly, should not be considered as alternatives to GAAP measures as indicators of operating performance. Further, EBITDA and Adjusted EBITDA should not be considered measures of the company’s liquidity.

A reconciliation of GAAP to non-GAAP financial measures has been provided in the tables included in this press release.

Note Regarding Forward-Looking Statements

Certain statements set forth in this press release constitute “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, but not limited to, statements concerning: the company’s expectations concerning its future financial and operating performance, business plans or prospects, including profitability; and the potential therapeutic and commercial value of alixorexton and the company’s other development candidates. The company cautions that forward-looking statements are inherently uncertain. The forward-looking statements are neither promises nor guarantees and they are necessarily subject to a high degree of uncertainty and risk. Actual performance and results may differ materially from those expressed or implied in the forward-looking statements due to various risks and uncertainties. These risks and uncertainties include, among others: whether the company is able to achieve its financial expectations, including those related to profitability; the businesses of Alkermes and Avadel may not be effectively integrated and the expected benefits and value of the acquisition may not be achieved; there may be unknown or inestimable liabilities and potential litigation associated with the acquisition; clinical development activities may not be completed on time or at all; the results of the company’s development activities may not be positive, or predictive of final results from such activities, results of future development activities or real-world results; the unfavorable outcome of arbitration, litigation, or other proceedings or disputes related to the company’s products or products using the company’s proprietary technologies; the company’s products or product candidates could be shown to be ineffective or unsafe; the U.S. Food and Drug Administration or regulatory authorities outside the U.S. may not agree with the company’s regulatory approval strategies or may make adverse decisions regarding the company’s products; the company and its licensees may not be able to continue to successfully commercialize their products or support revenue growth from such products; potential changes in the cost, scope and duration of the company’s development programs; there may be a reduction in payment rate or reimbursement for the company’s products or an increase in the company’s financial obligations to government payers; the company’s products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading “Risk Factors” in the company’s Annual Report on Form 10-K for the year ended Dec. 31, 2025 and in subsequent filings made by the company with the U.S. Securities and Exchange Commission (SEC), which are available on the SEC’s website at www.sec.gov. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Except as required by law, the

company disclaims any intention or responsibility for updating or revising any forward-looking statements contained in this press release.

VIVITROL® is a registered trademark of Alkermes, Inc.; ARISTADA®, ARISTADA INITIO® and LYBALVI® are registered trademarks of Alkermes Pharma Ireland Limited, used by Alkermes, Inc. under license; LUMRYZ® is a registered trademark of Flamel Ireland Limited, an affiliate of Alkermes plc; BYANNLI®, INVEGA HAFYERA®, INVEGA TRINZA®, TREVICTA® and XEPLION® are registered trademarks of Johnson & Johnson or its affiliated companies; and VUMERITY® is a registered trademark of Biogen MA Inc., used by Alkermes under license.

(tables follow)

The term “ARISTADA” as used in this press release refers to ARISTADA and ARISTADA INITIO®, unless the context indicates otherwise.

Alkermes plc and Subsidiaries

Selected Financial Information (Unaudited)

Condensed Consolidated Statements of Operations - GAAP

Three Months Ended

(In thousands, except per share data)

March 31, 2026

March 31, 2025

Revenues:

Product sales, net

338,114

244,493

Manufacturing and royalty revenues

54,797

62,017

Total Revenues

392,911

306,510

Expenses:

Cost of goods manufactured and sold

61,578

49,197

Research and development

103,345

71,817

Selling, general and administrative

264,593

171,704

Amortization of acquired intangible assets

11,675

—

Total Expenses

441,191

292,718

Operating (Loss) Income

(48,280

)

13,792

Other (Expense) Income, net:

Interest income

8,539

10,141

Interest expense

(20,892

)

—

Other (expense) income, net

(1,293

)

1,556

Total Other (Expense) Income, net

(13,646

)

11,697

(Loss) Income Before Income Taxes

(61,926

)

25,489

Income Tax (Benefit) Provision

4,554

3,025

Net (Loss) Income — GAAP

(66,480

)

22,464

(Loss) Earnings Per Share - Basic

(0.40

)

0.14

(Loss) Earnings Per Share - Diluted

(0.40

)

0.13

Weighted Average Number of Ordinary Shares Outstanding:

Basic

166,196

163,407

Diluted

166,196

168,737

An itemized reconciliation between net (loss) income on a GAAP basis and Adjusted EBITDA is as follows:

Net (Loss) Income

(66,480

)

22,464

Adjustments:

Interest income

(8,539

)

(10,141

)

Interest expense

20,892

—

Income tax provision

4,554

3,025

Depreciation expense

7,753

7,421

Amortization of acquired intangible assets

11,675

—

EBITDA

(30,145

)

22,769

Share-based compensation expense

54,581

22,810

Costs related to the acquisition of Avadel

55,825

—

Adjusted EBITDA

80,261

45,579

Alkermes plc and Subsidiaries

Selected Financial Information (Unaudited)

Condensed Consolidated Balance Sheets

March 31,

December 31,

(In thousands)

2026

2025

Cash, cash equivalents and total investments

538,225

588,360

Restricted cash

—

731,206

Receivables

407,630

334,025

Inventory

336,703

196,625

Prepaid expenses and other current assets

102,449

79,090

Property, plant and equipment, net

220,587

221,722

Intangible assets, net

1,784,040

815

Goodwill

596,029

83,027

Deferred tax assets

134,808

125,815

Other assets

137,605

126,308

Total Assets

4,258,076

2,486,993

Accrued sales discounts, allowances and reserves

272,843

247,126

Long-term debt, current portion

26,500

—

Other current liabilities

300,156

296,311

Long-term debt

1,483,837

—

Other long-term liabilities

423,209

124,261

Total shareholders' equity

1,751,531

1,819,295

Total Liabilities and Shareholders' Equity

4,258,076

2,486,993

Ordinary shares outstanding (in thousands)

166,462

165,607

This selected financial information should be read in conjunction with the consolidated financial statements and notes thereto included in Alkermes plc's Quarterly Report on Form 10-Q for the quarter ended March 31, 2026, which the company intends to file in May 2026.

Alkermes plc and Subsidiaries

Summary of Costs Related to the Acquisition of Avadel

Three Months Ended March 31, 2026

(In thousands)

GAAP Results

Costs Related to the Acquisition of Avadel (1)

Net of Costs Related to the Acquisition of Avadel

Three Months Ended March 31, 2025

Cost of goods manufactured and sold

61,578

12,726

48,852

49,197

Research and development

103,345

8,050

95,295

71,817

Selling, general and administrative

264,593

55,238

209,355

171,704

(1) Includes $20,188 of share-based compensation expense related to the acceleration of vesting of equity awards for Avadel employees which vested in full upon the closing of the transaction.

Alkermes plc and Subsidiaries

2026 Guidance — GAAP to EBITDA and Adjusted EBITDA

An itemized reconciliation between projected net loss on a GAAP basis, EBITDA and Adjusted EBITDA is as follows:

(In millions)

Amount

Projected Net Loss — GAAP

(80.0

)

Adjustments:

Net interest expense

80.0

Depreciation and amortization expense

120.0

Income tax benefit

—

Projected EBITDA

120.0

Share-based compensation expense

115.0

Costs related to the acquisition of Avadel

155.0

Projected Adjusted EBITDA

390.0

EX-99.2

Filename: alks-ex99_2.htm · Sequence: 3

First Quarter 2026Financial Results & Business Update May 5, 2026 Exhibit 99.2

Forward-Looking Statements and Non-GAAP Financial Information Certain statements set forth in this presentation constitute “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, but not limited to, statements concerning: Alkermes plc’s (the “Company”) expectations with respect to its current and future financial, commercial and operating performance, business plans or prospects, including profitability. The Company cautions that forward-looking statements are inherently uncertain. Actual performance and results may differ materially from those expressed or implied in the forward-looking statements due to various risks, assumptions and uncertainties. These risks, assumptions and uncertainties include, among others: whether the Company is able to achieve its financial expectations, including those related to profitability; the Company’s commercial activities may not result in the benefits that the Company anticipates; the businesses of the Company and Avadel Pharmaceuticals plc (“Avadel”) may not be effectively integrated and the expected benefits and value of the acquisition may not be achieved; there may be unknown or inestimable liabilities, potential litigation and transaction costs associated with the acquisition; clinical development activities may not be completed on time or at all; the results of the Company’s development activities may not be positive, or predictive of final results from such activities, results of future development activities or real-world results; potential changes in the cost, scope, design or duration of the Company’s development activities; the unfavorable outcome of arbitration, litigation, including so-called “Paragraph IV” litigation, or other proceedings or other disputes related to the Company’s products or products using the Company’s proprietary technologies; the U.S. Food and Drug Administration or other regulatory authorities may make adverse decisions regarding the Company’s products; the Company and its licensees may not be able to continue to successfully commercialize their products or support growth of such products; there may be a reduction in payment rate or reimbursement for the Company’s products or an increase in the Company’s financial obligations to government payers; the Company’s products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks, assumptions and uncertainties described under the heading “Risk Factors” in the Company’s Annual Report on Form 10-K for the year ended Dec. 31, 2025 and in subsequent filings made by the Company with the U.S. Securities and Exchange Commission (“SEC”), which are available on the SEC’s website at www.sec.gov, and on the Company’s website at www.alkermes.com in the ‘Investors – SEC Filings’ section. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Except as required by law, the Company disclaims any intention or responsibility for updating or revising any forward-looking statements contained in this presentation. Non-GAAP Financial Measures: This presentation includes information about certain financial measures that are not prepared in accordance with generally accepted accounting principles in the U.S. (“GAAP”), including EBITDA (earnings before interest, taxes, depreciation and amortization) and Adjusted EBITDA (excludes share‐based compensation expense and non‐recurring gains or losses in addition to the components of EBITDA from earnings). The Company provides these non-GAAP financial measures of the Company’s performance to investors because management believes that these non-GAAP financial measures, when viewed with the Company’s results under GAAP and the accompanying reconciliations, are useful in identifying underlying trends in ongoing operations. These non-GAAP measures are not based on any standardized methodology prescribed by GAAP and are not necessarily comparable to similar measures presented by other companies. Reconciliations of non-GAAP financial measures to the most directly comparable GAAP financial measures, to the extent reasonably determinable, can be found in the Appendix of this presentation. Note Regarding Trademarks: The Company and its affiliates are the owners of various U.S. federal trademark registrations (®) and other trademarks (TM), including ARISTADA®, ARISTADA INITIO®, LUMRYZ®, LYBALVI® and VIVITROL®. Any other trademarks referred to in this presentation are the property of their respective owners. Appearances of such other trademarks herein should not be construed as any indicator that their respective owners will not assert their rights thereto.

Q1 2026 Financial and Operational Performance

In millions Q1 2026 Financial Results Summary Total Revenue In millions GAAP Net Income/(Loss) GAAP Earnings (Loss) Per Share Diluted 2026 results reflect the acquisition of Avadel in February 2026, including six-weeks of revenue contribution from LUMRYZ® and certain expenses related to the acquisition.

In millions Q1 2026 Profitability GAAP Net Income/(Loss) In millions Adjusted EBITDA* EBITDA* In millions EBITDA represents earnings before interest, tax, depreciation and amortization. Adjusted EBITDA excludes share‐based compensation expense and non‐recurring gains or losses in addition to the components of EBITDA from earnings.*Reconciliation of this non-GAAP financial measure to the most directly comparable GAAP financial measure can be found in the Appendix of this presentation.

Q1 2026 Revenue Summary In millions Q1’26 Q1’25 Total Proprietary Net Sales $338.1 $244.5 VIVITROL® $112.4 $101.0 ARISTADA®* $93.8 $73.5 LYBALVI® $92.4 $70.0 LUMRYZ® $39.5 - Manufacturing & Royalty Revenue $54.8 $62.0 Total Revenue $392.9 $306.5 Amounts in the table may not sum due to rounding. *Inclusive of ARISTADA INITIO® **Represents LUMRYZ net sales recorded by Alkermes for the period of Feb. 12, 2026 - March 31, 2026. Prior to the completion of the acquisition, Avadel recorded LUMRYZ net sales of approximately $33 million between Jan. 1, 2026 and Feb. 11, 2026. . . **

Alkermes: 2026 Financial Expectations* a The acquisition of Avadel closed on Feb. 12, 2026. Expected net sales of LUMRYZ represents the period of Feb. 12, 2026 – Dec. 31, 2026. Avadel recorded net sales of LUMRYZ of approx. $33 million between Jan. 1, 2026 and Feb. 11, 2026. b In connection with the acquisition of Avadel, the Company expects to record approximately $125 million of LUMRYZ inventory fair value step-up, approximately $105 million of which is expected to be expensed as inventory is sold in 2026. c In connection with the acquisition of Avadel, the Company expects to record approximately $1.8 billion of intellectual property related to LUMRYZ, which will be amortized over an expected life of 14 years. *These expectations were provided by the Company on May 5, 2026 and are effective only as of such date. The Company expressly disclaims any obligation to update or reaffirm these expectations. ‡Reconciliation of this non-GAAP financial measure to the most directly comparable GAAP financial measure can be found in the Appendix of this presentation. i Inclusive of ARISTADA INITIO®. (in millions) Previous Financial Expectations for Year Ending Dec. 31, 2026 (provided Feb. 25, 2026) Updated Financial Expectations for Year Ending Dec. 31, 2026* (provided May 5, 2026) Total Revenues $1,730 – $1,840 $1,730 – $1,840 Cost of Goods Soldb $365 – $385 $320 – $340 R&D Expenses $445 – $485 $445 – $485 SG&A Expenses $890 – $930 $890 – $930 Amortization of Intangible Assetsc $95 – $105 $75 – $85 Net Interest Expense $75 – $85 $75 – $85 GAAP Net Loss ($115) – ($135) ($70) – ($90) EBITDA‡ $60 – $90 $105 – $135 Adjusted EBITDA‡ $370 – $410 $370 – $410 Net Tax Benefit ~$20 ~$0 Expected net sales of proprietary products: VIVITROL® net sales of $460M – $480M LYBALVI® net sales of $380M – $400M ARISTADA®i net sales of $365M – $385M LUMRYZ®a net sales of $315M – $335M EBITDA represents earnings before interest, tax, depreciation and amortization. Adjusted EBITDA excludes share‐based compensation expense and non‐recurring gains or losses in addition to the components of EBITDA from earnings.

Q1 2026 Commercial Review

VIVITROL® Performance and Expectations *These expectations were initially provided by the Company on Feb. 25, 2026, are reiterated by the Company on May 5, 2026 and are effective only as of such date. The Company expressly disclaims any obligation to update or reaffirm these expectations. Q1’26 VIVITROL net sales were $112.4M Outlook: FY’26 net sales expected to range from $460M – $480M* VIVITROL Quarterly Net Sales ($M)

ARISTADA® Performance and Expectations Q1’26 ARISTADA net sales were $93.8M Outlook: FY’26 net sales expected to range from $365M – $385M†* *Inclusive of ARISTADA INITIO®†These expectations were initially provided by the Company on Feb. 25, 2026, are reiterated by the Company on May 5, 2026 and are effective only as of such date. The Company expressly disclaims any obligation to update or reaffirm these expectations. ARISTADA Quarterly Net Sales* ($M)

LYBALVI® Performance and Expectations *These expectations were initially provided by the Company on Feb. 25, 2026, are reiterated by the Company on May 5, 2026 and are effective only as of such date. The Company expressly disclaims any obligation to update or reaffirm these expectations. Q1’26 LYBALVI net sales of $92.4M Q1’26 gross-to-net deductions: ~33% Outlook: FY’26 net sales expected to range from $380M – $400M* LYBALVI Quarterly Net Sales ($M)

LUMRYZ® Performance and Expectations *These expectations were initially provided by the Company on Feb. 25, 2026, are reiterated by the Company on May 5, 2026 and are effective only as of such date. The Company expressly disclaims any obligation to update or reaffirm these expectations. **LUMRYZ net sales for the quarter were $39.5 million, representing net sales during the period of Feb. 12, 2026 - March 31, 2026. Prior to the completion of the acquisition, Avadel recorded LUMRYZ net sales of approximately $33 million between Jan. 1, 2026 and Feb. 11, 2026. Q1’26 LUMRYZ net sales recorded by Alkermes were $39.5M Prior to the completion of the acquisition, Avadel recorded LUMRYZ net sales of ~$33M between Jan. 1, 2026 and Feb. 11, 2026 Outlook: FY’26 net sales expected to range from $315M – $335M* LUMRYZ Net Sales expectations represents the period of Feb. 12, 2026 – Dec. 31, 2026 LUMRYZ Quarterly Net Sales ($M) **

Appendix

Appendix: Financial Results GAAP to Non-GAAP Reconciliation (In millions) Three Months Ended March 31, 2026 Three Months Ended March 31, 2025 Net (Loss) Income — GAAP $ (66.5) $ 22.5 Adjustments: Depreciation expense 7.8 7.4 Amortization expense 11.7 - Interest income (8.5) (10.1) Interest expense 20.9 - Income tax provision 4.6 3.0 EBITDA (30.1) 22.8 Share-based compensation 54.6 22.8 Costs related to the acquisition of Avadel 55.8 -- Adjusted EBITDA $80.3 $ 45.6 Amounts in the table may not sum due to rounding.

Appendix: Financial Expectations GAAP to Non-GAAP Reconciliation Projected GAAP and non-GAAP measures in the table above reflect the mid-points within the Company’s financial expectations ranges. (In millions) Year Ended December 31, 2023 Year Ending December 31, 2026 Projected Net Loss — GAAP $ (80.0) Adjustments: Net interest expense 80.0 Depreciation and amortization expense 120.0 Income tax benefit -- Projected EBTIDA $ 120.0 Shared-based compensation expense 115.0 Costs related to the acquisition of Avadel 155.0 Projected Adjusted EBITDA $ 390.0

www.alkermes.com

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