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IONS SHAREHOLDER INVESTIGATION: Levi & Korsinsky Investigates Ionis Pharmaceuticals, Inc. For Possible Securities Law Violations

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IONS SHAREHOLDER INVESTIGATION: Levi & Korsinsky Investigates Ionis Pharmaceuticals, Inc. For Possible Securities Law Violations NEW YORK CITY, NY / ACCESS Newswire / July 14, 2026 / Levi & Korsinsky notifies investors that it has commenced an investigation into Ionis Pharmaceuticals, Inc. ("Ionis Pharmaceuticals, Inc.") (NASDAQ:IONS) concerning potential violations of the federal securities laws.

Ionis Pharmaceuticals shares were falling more than 20% on July 9, 2026, after the Company disclosed that its Phase-3 CARDIO-TTRansform trial failed to meet its primary endpoint.

The investigation concerns whether the Company's prior public statements regarding the CARDIO-TTRansform program aligned with the trial's ultimate outcome. On November 6, 2024, CEO Brett Monia stated on the Company's Q3 2024 earnings call that the "ongoing CARDIO-TTRansform trial [was] on track to deliver the most comprehensive dataset in these patients in the second half of 2026." More recently, on June 10, 2026, CEO Monia reiterating that data was expected in the back half of the year, told investors "everything is going very well in the conduct of the study and the execution. The study is reasonably derisked for its primary endpoint. We're excited."

On July 9, 2026, the company disclosed that its trial, partnered with AstraZeneca, did not meet its primary endpoint of reducing combined cardiovascular death and recurrent events in transthyretin-mediated amyloid cardiomyopathy patients. The stock opened down more than 20% on the news.

If you suffered a loss on your Ionis Pharmaceuticals, Inc. securities and would like to explore a potential recovery under the federal securities laws, Learn More About the Investigation or contact Joseph E. Levi, Esq. via email at [email protected] or call (212)363-7500 to speak to our team of experienced shareholder advocates.

WHY LEVI & KORSINSKY: Over the past 20 years, Levi & Korsinsky LLP has established itself as a nationally-recognized securities litigation firm that has secured hundreds of millions of dollars for aggrieved shareholders and built a track record of winning high-stakes cases. The firm has extensive expertise representing investors in complex securities litigation and a team of over 70 employees to serve our clients. For seven years in a row, Levi & Korsinsky has ranked in ISS Securities Class Action Services' Top 50 Report as one of the top securities litigation firms in the United States. Attorney Advertising. Prior results do not guarantee similar outcomes.

CONTACT:

Levi & Korsinsky, LLP

Joseph E. Levi, Esq.

Ed Korsinsky, Esq.

33 Whitehall Street, 27th Floor

New York, NY 10004

[email protected]

Tel: (212)363-7500

Fax: (212)363-7171

SOURCE: Levi & Korsinsky, LLP