Form 8-K/A

8-K/A — NEUROCRINE BIOSCIENCES INC

Accession: 0001193125-26-328470

Filed: 2026-07-31

Period: 2026-05-14

CIK: 0000914475

SIC: 2836 (BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES))

Item: Financial Statements and Exhibits

Documents

8-K/A — d73154d8ka.htm (Primary)

EX-23.1 (d73154dex231.htm)

EX-23.2 (d73154dex232.htm)

EX-99.3 (d73154dex993.htm)

GRAPHIC (g73154g0729152228095.jpg)

XML — IDEA: XBRL DOCUMENT (R1.htm)

8-K/A

8-K/A (Primary)

Filename: d73154d8ka.htm · Sequence: 1

8-K/A

NEUROCRINE BIOSCIENCES INC true 0000914475 0000914475 2026-05-14 2026-05-14

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 8-K/A

(AMENDMENT NO. 1)

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): May 14, 2026

NEUROCRINE BIOSCIENCES, INC.

(Exact name of Registrant as Specified in Its Charter)

Delaware

0-22705

33-0525145

(State or Other Jurisdiction

of Incorporation)

(Commission

File Number)

(IRS Employer

Identification No.)

6027 Edgewood Bend Court

San Diego, California

92130

(Address of Principal Executive Offices)

(Zip Code)

(858) 617-7600

(Registrant’s telephone number, including area code)

N/A

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class

Trading

Symbol

Name of each exchange

on which registered

Common Stock, $0.001 par value

NBIX

Nasdaq Global Select Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Explanatory Note

This Amendment No. 1 on Form 8-K/A (this “Amendment No. 1”) amends the Current Report on Form 8-K filed by Neurocrine Biosciences, Inc., a Delaware corporation (the “Company”) on May 18, 2026 (the “Original Report”), in which the Company reported, among other events, the completion of the Merger (as defined in the Original Report). This Amendment No. 1 is filed to (i) update the information in Item 9.01(a) of the Original Report to include the audited consolidated financial statements of Soleno (as defined in the Original Report) as of and for the year ended December 31, 2025 and to include the unaudited interim condensed consolidated financial statements of Soleno as of and for the three months ended March 31, 2026; and (ii) update the information in Item 9.01(b) of the Original Report to include the unaudited pro forma condensed combined financial information of the Company, consisting of the unaudited pro forma condensed combined statements of income for the six months ended June 30, 2026 and the year ended December 31, 2025. This Amendment No. 1 does not amend any other item of the Original Report or purport to provide an update or a discussion of any developments at the Company subsequent to the filing date of the Original Report.

Capitalized terms used but not defined herein have the meanings given to them in the Original Report.

In accordance with Rule 12b-15 of the Securities Exchange Act of 1934, as amended, the complete text of Item 9.01 (as amended) is included herein.

Item 9.01.

Financial Statements and Exhibits.

(a)

Financial statements of businesses or funds acquired.

The audited consolidated financial statements of Soleno as of and for the year ended December 31, 2025, the related notes thereto, and the report of CBIZ CPAs P.C., Soleno’s independent registered public accounting firm, are incorporated herein by reference as Exhibit 99.1.

The unaudited interim condensed consolidated financial statements of Soleno as of and for the three months ended March 31, 2026 and the related notes thereto are incorporated herein by reference as Exhibit 99.2.

(b)

Pro forma financial information.

The unaudited pro forma condensed combined financial information of the Company, consisting of the unaudited pro forma condensed combined statements of income for the six months ended June 30, 2026 and the year ended December 31, 2025 is attached hereto as Exhibit 99.3 and incorporated herein by reference.

(d)

Exhibits.

Exhibit

Number

Description

2.1*

Agreement and Plan of Merger, dated April 5, 2026, by and among Neurocrine Biosciences, Inc., Sigma Merger Sub, Inc. and Soleno Therapeutics, Inc. (incorporated by reference to Exhibit 2.1 to the Current Report on Form 8-K filed by Neurocrine Biosciences, Inc. with the Securities and Exchange Commission on April 6, 2026).

10.1*

Credit Agreement, dated May 14, 2026, among Neurocrine Biosciences, Inc., JPMorgan Chase Bank, N.A., as administrative agent, and the lenders party thereto (previously filed with the Original Report).

23.1

Consent of CBIZ CPAs P.C.

23.2

Consent of Marcum LLP.

99.1

Audited Consolidated Financial Statements of Soleno Therapeutics, Inc. and its consolidated subsidiaries as of and for the year ended December 31, 2025, the related notes thereto and the report of CBIZ CPAs P.C. (incorporated by reference to Part II, Item 8 of the Annual Report on Form 10-K of Soleno Therapeutics, Inc. for the year ended December 31, 2025, filed with the Securities and Exchange Commission on February 25, 2026 (File No. 001-36593)).

99.2

Unaudited Interim Condensed Consolidated Financial Statements of Soleno Therapeutics, Inc. and its consolidated subsidiaries as of and for the three months ended March 31, 2026 and the related notes thereto (incorporated by reference to Part I, Item 1 of the Quarterly Report on Form 10-Q of Soleno Therapeutics, Inc. for the quarter ended March 31, 2026, filed with the Securities and Exchange Commission on May 7, 2026 (File No. 001-36593)).

99.3

Unaudited Pro Forma Condensed Combined Financial Information of Neurocrine Biosciences, Inc., consisting of the unaudited pro forma condensed combined statements of income for the six months ended June 30, 2026 and the year ended December 31, 2025.

104

Cover Page Interactive Data File (embedded within the Inline XBRL document).

Certain annexes, exhibits or schedules have been omitted pursuant to Item 601(a)(5) of Regulation S-K. The registrant hereby undertakes to furnish supplemental copies of any of the omitted annexes, exhibits and schedules upon request by the U.S. Securities and Exchange Commission.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

NEUROCRINE BIOSCIENCES, INC.

Dated: July 31, 2026

/s/ Darin M. Lippoldt

Darin M. Lippoldt

Chief Legal Officer

EX-23.1

Filename: d73154dex231.htm · Sequence: 2

EX-23.1

Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in this Current Report on Form 8-K/A and in the following registration

statements:

(1) Registration Statements (Form S-8 Nos.

333-175889, 333-190178, 333-197916, and 333-212871) pertaining to the 2011 Equity

Incentive Plan of Neurocrine Biosciences, Inc.,

(2) Registration Statements (Form S-8 Nos. 333-199837 and 333-216067) pertaining to the Inducement Plan of Neurocrine Biosciences, Inc.,

(3) Registration Statements (Form S-8 Nos. 333-205933 and 333-223020) pertaining to the 2011 Equity Incentive Plan and Inducement Plan of Neurocrine Biosciences, Inc.,

(4) Registration Statement (Form S-8 No. 333-226971)

pertaining to the 2011 Equity Incentive Plan and 2018 Employee Stock Purchase Plan of Neurocrine Biosciences, Inc.,

(5) Registration

Statement (Form S-8 No. 333-234501) pertaining to the 2011 Equity Incentive Plan of Neurocrine Biosciences, Inc.,

(6) Registration Statement (Form S-8 No. 333-240301)

pertaining to the 2020 Equity Incentive Plan of Neurocrine Biosciences, Inc.,

(7) Registration Statement (Form S-8 No. 333-266530) pertaining to the 2020 Equity Incentive Plan and 2018 Employee Stock Purchase Plan of Neurocrine Biosciences, Inc.

(8) Registration Statements (Form S-8 Nos. 333-273554 and 333-281163) pertaining to the 2020 Equity Incentive Plan of Neurocrine Biosciences, Inc., and

(9)

Registration Statement (Form S-8 No. 333-287477) pertaining to the 2025 Equity Incentive Plan and 2018 Employee Stock Purchase Plan of Neurocrine Biosciences, Inc.

of our reports dated February 25, 2026 with respect to our audits of the consolidated financial statements of Soleno Therapeutics, Inc. as of and

for the year ended December 31, 2025 and the effectiveness of internal control over financial reporting of Soleno Therapeutics, Inc. as of December 31, 2025 included in the Annual Report

on Form 10-K of Soleno Therapeutics, Inc.

/s/ CBIZ CPAs P.C.

San Francisco, CA

July 31, 2026

EX-23.2

Filename: d73154dex232.htm · Sequence: 3

EX-23.2

Exhibit 23.2

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in this Current Report on Form 8-K/A and in the following registration

statements:

(1) Registration Statements (Form S-8 Nos.

333-175889, 333-190178, 333-197916, and 333-212871) pertaining to the 2011 Equity

Incentive Plan of Neurocrine Biosciences, Inc.,

(2) Registration Statements (Form S-8 Nos. 333-199837 and 333-216067) pertaining to the Inducement Plan of Neurocrine Biosciences, Inc.,

(3) Registration Statements (Form S-8 Nos. 333-205933 and 333-223020) pertaining to the 2011 Equity Incentive Plan and Inducement Plan of Neurocrine Biosciences, Inc.,

(4) Registration Statement (Form S-8 No. 333-226971)

pertaining to the 2011 Equity Incentive Plan and 2018 Employee Stock Purchase Plan of Neurocrine Biosciences, Inc.,

(5) Registration

Statement (Form S-8 No. 333-234501) pertaining to the 2011 Equity Incentive Plan of Neurocrine Biosciences, Inc.,

(6) Registration Statement (Form S-8 No. 333-240301)

pertaining to the 2020 Equity Incentive Plan of Neurocrine Biosciences, Inc.,

(7) Registration Statement (Form S-8 No. 333-266530) pertaining to the 2020 Equity Incentive Plan and 2018 Employee Stock Purchase Plan of Neurocrine Biosciences, Inc.

(8) Registration Statements (Form S-8 Nos. 333-273554 and 333-281163) pertaining to the 2020 Equity Incentive Plan of Neurocrine Biosciences, Inc., and

(9)

Registration Statement (Form S-8 No. 333-287477) pertaining to the 2025 Equity Incentive Plan and 2018 Employee Stock Purchase Plan of Neurocrine Biosciences, Inc.

of our report dated February 28, 2025 with respect to our audit of the consolidated financial statements of Soleno Therapeutics, Inc. as of December 31, 2024 and for each of the two years in the period ended December 31, 2024 included in the Annual Report on Form 10-K of Soleno Therapeutics, Inc.

/s/

MARCUM LLP

San Francisco, CA

July 31,

2026

EX-99.3

Filename: d73154dex993.htm · Sequence: 4

EX-99.3

Exhibit 99.3

UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION

Introduction

On May 18, 2026 (the

“Closing Date”), Neurocrine Biosciences, Inc. (“Neurocrine” or the “Company”) completed the previously announced acquisition (the “Acquisition” or “Transaction”) of Soleno

Therapeutics, Inc. (“Soleno”). On May 14, 2026, the Company also entered into a credit agreement (see Note 1) (the “Credit Agreement”) to fund its working capital needs post-Acquisition. The unaudited pro forma condensed

combined statements of income (the “unaudited pro forma condensed combined financial information”) give effect to the Acquisition, as described further in Note 1 below, and were prepared in accordance with the requirements of Article 11

of Regulation S-X.

The unaudited pro forma condensed combined financial information gives effect

to the Acquisition (the “Transaction Accounting Adjustments”) as if it had occurred on January 1, 2025 for purposes of the unaudited pro forma condensed combined statements of income for the six months ended June 30, 2026 and

for the year ended December 31, 2025.

In accordance with Rule 11-02(c)(1) of Regulation S-X, the unaudited pro forma condensed combined financial information is not required to, and does not, include an unaudited pro forma condensed combined balance sheet as of June 30, 2026 because the

Acquisition is already reflected in the Company’s historical condensed consolidated balance sheet as of June 30, 2026, included in the Company’s Quarterly Report on Form 10-Q for the quarter

ended June 30, 2026, filed with the Securities and Exchange Commission (“SEC”) on July 31, 2026.

The unaudited pro

forma condensed combined financial information was prepared in accordance with Article 11 of Regulation S-X using accounting policies in accordance with U.S. Generally Accepted Accounting Principles

(“U.S. GAAP”). The unaudited pro forma condensed combined financial information (1) was prepared using the acquisition method of accounting pursuant to Accounting Standards Codification 805, Business Combinations

(“Topic 805”), with the Company being the accounting acquirer, and (2) has been adjusted to give pro forma effect to the Company and Soleno’s historical consolidated financial statements to account for the Acquisition.

In accordance with Topic 805, the Company used its best estimates and assumptions to assign fair values to the tangible and identifiable

intangible assets acquired and liabilities assumed, and to the related income tax impacts as of the Closing Date. The estimated excess of the purchase price over the fair value of identifiable assets acquired and liabilities assumed was allocated to

goodwill. The estimated fair values of the assets acquired and liabilities assumed are considered preliminary and are based on the information that was available as of the Closing Date. Actual future results of the combined company may differ

significantly from the pro forma amounts presented here due to various factors, including differences between the preliminary purchase price allocation and the final allocation, future business performance, integration efforts, and market

conditions. In the opinion of the Company’s management, the unaudited pro forma condensed combined financial information includes all material adjustments necessary to be in accordance with Article 11 of Regulation S-X. The Company intends to finalize the acquisition accounting as soon as practicable within the required measurement period, but in no event later than the date that is one year following the Closing Date.

The unaudited pro forma condensed combined financial information is presented for illustrative purposes only. Such information is not

necessarily indicative of the operating results or financial position that would have been achieved if the Acquisition had been consummated on the date indicated, or that the combined company may achieve in future periods. Further, the unaudited pro

forma condensed combined financial information does not reflect any revenue and operating synergies or cost savings that may result from the Acquisition.

The unaudited pro forma condensed combined financial information for the year ended December 31, 2025 and for the six months ended

June 30, 2026 is derived from:

•

The historical unaudited Condensed Consolidated Financial Statements and accompanying notes of Neurocrine as of

and for the six months ended June 30, 2026, included in its Quarterly Report on Form 10-Q for the quarterly period ended June 30, 2026, as filed with the SEC on July 31, 2026;

•

The historical audited Consolidated Financial Statements and accompanying notes of Neurocrine as of and for the

year ended December 31, 2025 included in its Annual Report on Form 10-K for the year ended December 31, 2025, as filed with the SEC on February 11, 2026;

•

The historical unaudited Condensed Consolidated Financial Statements and accompanying notes of Soleno as of and

for the three months ended March 31, 2026, included in its Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2026, as filed with the SEC on May 7, 2026;

•

The historical audited Consolidated Financial Statements and accompanying notes of Soleno as of and for the year

ended December 31, 2025, included in its amended Annual Report on Form 10-K/A for the year ended December 31, 2025, as filed with the SEC on April 30, 2026; and

•

The historical unaudited consolidated statement of operations of Soleno for the stub period of April 1, 2026

through May 17, 2026 derived from Soleno’s books and records.

All terms defined in this Exhibit 99.3 are

used solely for the purposes of Exhibit 99.3 and do not apply to any other section of the Form 8-K/A of which this exhibit forms a part.

Neurocrine Biosciences, Inc.

Unaudited Pro Forma Condensed Combined Statement of Income

Six months ended June 30, 2026

(in millions, except per share data)

Historical

Neurocrine for

the six month

period ended

6/30/2026

(As Reported)

Historical

Soleno for the

three month

period ended

3/31/2026

(As Adjusted)

(Note

Historical

Soleno for

the period

4/1/2026 to

5/17/2026

Transaction

Accounting

Adjustments

Note

Pro Forma

Combined

Note

Revenues:

Net product sales

1,765.3

94.6

39.4

1,899.3

Collaboration revenues

8.2

—

8.2

Total revenues

1,773.5

94.6

39.4

—

1,907.5

Operating expenses:

Cost of revenues, excluding amortization of acquired intangible assets

36.9

1.2

0.8

15.1

4(a)

52.0

(1.8

)

4(b)

(0.2

)

4(c)

Research and development

622.9

16.9

5.6

(18.1

)

4(b)

625.3

(2.0

)

4(c)

Acquired in-process research and development

22.7

—

22.7

Selling, general and administrative

758.2

44.8

109.2

(40.2

)

4(b)

867.4

(4.6

)

4(c)

Amortization of acquired intangible assets

16.5

—

53.6

4(d)

70.1

Change in fair value of contingent consideration

—

0.5

0.1

0.6

Gain of sale of business, net of transaction costs

(28.6

)

—

(28.6

)

Total operating expenses

1,428.6

63.4

115.7

1.8

1,609.5

Operating income (loss)

344.9

31.2

(76.3

)

(1.8

)

298.0

Other income (expense):

Interest expense

(2.9

)

(1.3

)

(3.7

)

5.0

4(e)

(2.9

)

Unrealized gain on equity investments

26.5

—

26.5

Investment income and other, net

40.5

4.9

0.2

45.6

Total other income (expense), net

64.1

3.6

(3.5

)

5.0

69.2

Income (loss) before provision for income taxes

409.0

34.8

(79.8

)

3.2

367.2

Provision for income taxes

66.7

3.5

—

3.0

4(f)

73.2

Net income (loss)

342.3

31.3

(79.8

)

0.2

294.0

Earnings per share:

Basic

3.40

2.92

5(a)

Diluted

3.30

2.83

5(a)

Weighted average shares outstanding:

Basic

100.8

5(a)

Diluted

103.8

5(a)

See accompanying notes to the unaudited pro forma condensed combined financial information.

Neurocrine Biosciences, Inc.

Unaudited Pro Forma Condensed Combined Statement of Income

Year Ended December 31, 2025

(in millions, except per share data)

Historical Neurocrine

(As Reported)

Historical Soleno

(As Adjusted)

(Note 3)

Transaction

Accounting

Adjustments

Note

Pro Forma

Combined

Note

Revenues:

Net product sales

2,833.9

190.4

3,024.3

Collaboration revenues

26.6

—

26.6

Total revenues

2,860.5

190.4

—

3,050.9

Operating expenses:

Cost of revenues, excluding amortization of acquired intangible assets

52.1

2.7

28.8

4(a)

85.6

1.8

4(b)

0.2

4(c)

Research and development

1,015.7

46.2

18.1

4(b)

1,082

2.0

4(c)

Acquired in-process research and development

17.4

—

17.4

Selling, general and administrative

1,156.2

126.5

40.2

4(b)

1,327.5

4.6

4(c)

Amortization of acquired intangible assets

—

139.9

4(d)

139.9

Change in fair value of contingent consideration

—

5.5

Total operating expenses

2,241.4

180.9

235.6

2,657.9

Operating income

619.1

9.5

(235.6

)

393.0

Other income (expense):

Unrealized (loss) on equity investments

(4.0

)

—

(4.0

)

Interest expense

—

(5.5

)

5.5

4(e)

—

Investment income and other, net

90.3

17.0

107.3

Total other income (expense), net

86.3

11.5

5.5

103.3

Income before provision for income taxes

705.4

21.0

(230.1

)

496.3

Provision for income taxes

226.8

—

(55.0

)

4(f)

171.8

Net income

478.6

21.0

(175.1

)

324.5

Earnings per share:

Basic

4.81

3.26

5(a)

Diluted

4.67

3.17

5(a)

Weighted average shares outstanding:

Basic

99.5

5(a)

Diluted

102.5

5(a)

See accompanying notes to the unaudited pro forma condensed combined financial information.

NOTES TO THE UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION

Note 1 – Description of the Transaction

In April 2026, the Company, Sigma Merger Sub, Inc., a wholly owned subsidiary of the Company formed solely to facilitate the Acquisition, and

Soleno entered into a definitive Agreement and Plan of Merger (the “Merger Agreement”), pursuant to which the Company agreed to commence a cash tender offer to purchase all of the issued and outstanding shares of common stock, par value

$0.001 per share, of Soleno (the “Shares”) at a price of $53.00 per Share (the “Offer Price”), payable in cash, without interest and subject to any required withholding of taxes, at closing. On the Closing Date, the Company

successfully completed the Acquisition, adding VYKAT™ XR (diazoxide choline), a first-in-class therapy to treat

hyperphagia in Prader-Willi syndrome to its portfolio of innovative medicines to strengthen its leadership position in endocrinology and rare disease.

Additionally, on the Closing Date and at the effective time of the Acquisition (the “Effective Time”), pursuant to the Merger

Agreement, Soleno’s equity awards were treated as follows:

(i)

each option to purchase Shares (a “Soleno Option”) that was outstanding and unexercised as of

immediately prior to the Effective Time and that was not an Out of the Money Soleno Option (as defined below), whether or not then vested or exercisable, became fully vested and was cancelled and converted into the right to receive an amount in

cash, without interest and subject to any applicable withholding taxes, equal to (A) the total number of Shares subject to such Soleno Option immediately prior to such cancellation multiplied by (B) the excess, if any, of (x) the

Offer Price over (y) the exercise price payable per Share underlying such Soleno Option. Each Soleno Option that had an exercise price per Share that was equal to or greater than the Offer Price (an “Out of the Money Soleno Option”)

that was outstanding and unexercised immediately prior to the Effective Time, whether or not then vested or exercisable, was cancelled and no holder thereof was entitled to any payment with respect to such Soleno Option before or after the Effective

Time; and

(ii)

each restricted stock unit award with respect to Shares (a “Soleno RSU Award”) that was outstanding

as of immediately prior to the Effective Time, whether or not then vested, became fully vested and was cancelled and converted into the right to receive an amount in cash, without interest and subject to any applicable withholding taxes, equal to

(A) the number of Shares subject to such Soleno RSU Award immediately prior to such cancellation multiplied by (B) the Offer Price; and

(iii)

each warrant to purchase Shares (a “Soleno Warrant”) that was outstanding and unexercised

immediately prior thereto, whether vested or unvested, was treated as being simultaneously cashless exercised as of immediately prior to the Effective Time, in accordance with the terms and conditions specified in the applicable Soleno Warrant and

subject to deduction for any applicable withholding taxes.

These equity-related settlements are reflected in the

unaudited pro forma condensed combined financial information as either consideration transferred attributable to pre-combination services or post-combination expense attributable to post-combination services.

Additionally, on May 14, 2026, the Company entered into the Credit Agreement with JPMorgan Chase Bank, N.A., as administrative agent

and collateral agent, and the lenders party thereto. The Credit Agreement provides for a five-year, $1.0 billion senior secured revolving credit facility (the “Revolving Credit Facility”). Interest rates under the Revolving Credit

Facility are variable and equal to, at the Company’s option, (i) Term SOFR (as defined in the Credit Agreement), plus a margin of 1.125% to 1.75% per annum, or (ii) an alternate base rate plus a margin of 0.125% to 0.75% per annum,

in each case based on the lower of the applicable rates determined by reference to the Company’s total secured net leverage ratio and credit ratings from time to time.

The Company will pay customary agency fees and a commitment fee based on the daily unused portion of the Revolving Credit Facility at a rate

of 0.10% to 0.25% per annum based on the lower of the applicable rates determined by reference to the Company’s secured net leverage ratio and credit ratings from time to time. The Revolving Credit Facility is not subject to amortization and

will mature on the fifth anniversary of the closing date of the Credit Agreement. On May 18, 2026, the Company drew $600.0 million under the Revolving Credit Facility selecting a Term Benchmark Borrowing (as defined in the Credit

Agreement) with interest to be paid every three months (first payment due August 14, 2026). Accordingly, the initial interest rate shall be set at 4.896%, calculated as Term SOFR plus 1.25%.

As of June 30, 2026, the Company had repaid the full $600.0 million outstanding

under the Revolving Credit Facility. Because both the borrowing and subsequent repayment are reflected in the Company’s historical financial statements as of June 30, 2026, no Transaction Accounting Adjustments related to the drawdown or

repayment have been included in the unaudited pro forma condensed combined financial information. Additionally, no adjustments associated with the interest expense related to the drawdown and amortization expense related to deferred financing fees

have been reflected in the unaudited pro forma condensed combined financial information as such amounts were not material.

Note 2 – Basis of

Presentation

The unaudited pro forma condensed combined financial information was prepared in accordance with Article 11 of Regulation

S-X. The unaudited pro forma condensed combined statements of income for the six months ended June 30, 2026 and the year ended December 31, 2025 give effect to the Acquisition as if it had been

consummated on January 1, 2025. The Acquisition has been accounted for as a Business Combination under Topic 805. Upon completion of the Acquisition, the Company controlled Soleno, and accordingly, was determined to be the accounting acquirer.

Refer to Note 2 of the Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2026, filed with the SEC on July 31, 2026, for information on the purchase consideration, fair

value estimates of the assets acquired and liabilities assumed, and resulting goodwill as of the acquisition date.

The Transaction

Accounting Adjustments are based on preliminary estimates and currently available information and on assumptions that Neurocrine management believes are reasonable under the circumstances. These notes to the unaudited pro forma condensed combined

financial information describe how such Transaction Accounting Adjustments were derived and are presented in the unaudited pro forma condensed combined statements of income. Certain reclassifications have been made to the historical

presentation of Soleno’s financial statements in order to conform to the financial statement presentation of the Company. These reclassifications are discussed further in Note 3 below. There have been no other material accounting policy

differences identified between those of the Company and those of Soleno during the periods presented.

The unaudited pro forma condensed

combined financial information is provided for illustrative purposes only and does not purport to represent what the actual consolidated results of Neurocrine and Soleno would have been had the Acquisition been consummated on January 1, 2025

for presentation in the unaudited pro forma condensed combined statements of income, nor are they necessarily indicative of future consolidated results of operations of the Company. The unaudited pro forma condensed combined statements of income do

not include management adjustments to reflect the costs of any integration activities, nor any synergies or benefits that may result from realization of any anticipated revenue growth or operational efficiencies expected to result from the

Acquisition.

Note 3 – Reclassification Adjustments

During the preparation of the unaudited pro forma condensed combined financial information, the Company reviewed available information related

to the accounting policies and financial statement presentation of Neurocrine and Soleno. As a result of that review, certain balances were reclassified from the Soleno financial statements so that their presentation would be consistent with that of

the Company’s financial statements. Further, as a result of such review, the Company did not identify any other material accounting policy differences between the accounting policies of Neurocrine and Soleno that, when conformed, could have a

material impact on the unaudited pro forma condensed combined financial information.

The following table presents Soleno’s adjusted unaudited statement of income for the

three months ended March 31, 2026, to conform with that of Neurocrine (in millions):

Soleno’s financial

statement line item

Neurocrine’s financial

statement line item

Soleno’s Historical

for the three

months ended

March 31, 2026

(As reported)

Reclassification

Adjustments

Notes

Soleno’s Adjusted

Statement of

Income for the

three months ended

March 31, 2026

Product revenue, net

Net product sales

94.6

Operating expenses:

Cost of goods sold

Cost of revenues, excluding amortization of acquired intangible assets

1.2

Research and development

11.3

5.6

)

16.9

Selling, general and administrative

50.4

(5.6

)

44.8

Change in fair value of contingent consideration

0.5

Total operating expenses

63.4

Operating income (loss)

31.2

Other income (expense), net

Interest income, net

4.9

(4.9

)

—

Investment income and other, net

4.9

)

4.9

Interest expense

(1.3

)

(1.3

)

Total other income (expense), net

3.6

—

3.6

Income (loss) before provision for income taxes

34.8

—

34.8

Provision for income taxes

3.5

Net income (loss)

31.3

—

31.3

(a)

Represents a reclassification to align Soleno’s departmental expense classifications within operating

expenses with Neurocrine’s presentation.

(b)

Represents a reclassification of “Interest income, net” to “Investment income and other,

net” to conform to Neurocrine’s financial statement line item.

The following table presents Soleno’s

adjusted unaudited statement of income for the year ended December 31, 2025, to conform with that of Neurocrine (in millions):

Soleno’s financial statement

line item

Neurocrine’s

financial statement

line item

Soleno’s Historical

for the year ended

December 31, 2025

(As reported)

Reclassification

Adjustments

Notes

Soleno’s Adjusted

Statement of

Income for the year

ended December 31,

2025

Product revenue, net

Net product sales

190.4

Operating expenses:

Cost of goods sold

Cost of revenues, excluding amortization of acquired intangible assets

2.7

Research and development

40.6

5.6

)

46.2

Selling, general and administrative

132.1

(5.6

)

126.5

Change in fair value of contingent consideration

5.5

Total operating expenses

180.9

Operating income (loss)

9.5

Other income (expense), net

Interest income, net

17.0

(17.0

)

—

Investment income and other, net

17.0

)

17.0

Interest expense

(5.5

)

(5.5

)

Total other income (expense), net

11.5

—

11.5

Income (loss) before provision for income taxes

21.0

—

21.0

Provision for income taxes

—

Net income (loss)

21.0

—

21.0

(a)

Represents a reclassification to align Soleno’s departmental expense classifications within operating

expenses with Neurocrine’s presentation.

(b)

Represents a reclassification of “Interest income, net” to “Investment income and other,

net” to conform to Neurocrine’s financial statement line item.

Note 4 – Transaction Accounting Adjustments to the Unaudited Pro Forma Condensed Combined

Statements of Income

The pro forma adjustments are based on the Company’s preliminary estimates and assumptions, which are

subject to change. The following adjustments have been reflected in the unaudited pro forma condensed combined statements of income:

(a)

Reflects an increase to cost of revenues of $15.1 million and $28.8 million for the six

months ended June 30, 2026 and the year ended December 31, 2025, respectively, related to the amortization of the fair-value step-up to inventory recognized as part of the acquisition accounting. The Company recorded a fair value step-up of $168.2 million to inventory as of the Closing Date, which is expected to be recognized as an increase in cost of revenues as the related inventory is produced and sold. This adjustment

reflects the incremental expense associated with the fair value step-up based on forecasted inventory turnover and production cycles, which was approximated to be 4 to 6 years, calculated as follows:

Six Months Ended

Year Ended

(in millions)

June 30, 2026

December 31, 2025

Removal of amortization related to inventory step-up

recorded in post-acquisition period

(3.0

)

—

Inventory step-up amortization

18.1

28.8

Net pro forma adjustment to cost of revenues

15.1

28.8

(b)

Reflects the reclassification of share-based compensation expense related to awards that were accelerated and

settled in cash by the Company on the Closing Date. Because the expense was recognized during the six months ended June 30, 2026, the adjustment reflects the attribution of such expense as if it were incurred on January 1, 2025.

(c)

Reflects the reclassification of non-recurring expenses related to

transaction bonus payments to certain Soleno employees that were paid on the Closing Date. Because the expense was recognized during the six months ended June 30, 2026, the adjustment reflects the attribution of such expense as if it were

incurred on January 1, 2025.

(d)

Represents the incremental amortization expense associated with the preliminary fair value of the

acquisition-related definite-lived intangible asset for the six months ended June 30, 2026 and the year ended December 31, 2025.

The adjustment for the incremental amortization of the definite-lived identifiable intangible asset, calculated using the straight-line method,

is as follows:

Amortization Expense

(in millions)

Estimated

Useful Life

(Years)

Estimated

Fair Value

Six Months

Ended June 30,

2026

Year Ended

December 31,

2025

VYKAT XR

16.0

2,237.8

69.9

139.9

Removal of amortization expense recorded in post-acquisition period

(16.3

)

—

Pro forma adjustment for incremental amortization expense

53.6

139.9

These preliminary estimates of fair value and estimated useful lives may differ from final

amounts the Company will calculate after completing a detailed valuation analysis, and the difference could have a material effect on the accompanying unaudited pro forma condensed combined financial information. A 10% change in the valuation of

intangible assets would cause a corresponding increase or decrease in amortization expense of approximately $7.0 million and $13.9 million for the six months ended June 30, 2026 and the year ended December 31, 2025, respectively,

under the straight-line method.

(e)

Represents the elimination of historical interest expense, amortization of debt issuance costs and loss on

extinguishment associated with Soleno’s promissory notes with Oxford Finance LLC for the six months ended June 30, 2026 and the year ended December 31, 2025, as the notes were fully repaid on the Closing Date.

(f)

Represents the income tax expense for the six months ended June 30, 2026 and the income tax benefit for

the year ended December 31, 2025 resulting from the Transaction Accounting Adjustments using the statutory tax rates in effect in the U.S for each period. Because the Transaction Accounting Adjustments contained in these unaudited pro forma

financial statements are based on estimates, the actual effective tax rate will likely vary from the effective rate in periods subsequent to the Acquisition.

Transaction costs of approximately $33.1 million are included in the historical unaudited Condensed Consolidated Statement of Income of the Company for

the six months ended June 30, 2026. No additional transaction costs were incurred by the Company subsequent to June 30, 2026. Accordingly, no adjustment has been made to accrue additional transaction costs in the unaudited pro forma

condensed combined financial information.

Note 5 – Pro Forma Earnings Per Share

(a)

Represents basic earnings per share, which is calculated based upon pro forma net income divided by the

weighted average number of common shares outstanding during the period. For the calculation of diluted earnings per share, the Company utilizes the treasury stock and if-converted methods to reflect the

weighted average number of common and potentially dilutive shares outstanding during the period, excluding those whose effect would be anti-dilutive. There were no pro forma effects to the weighted average number of common shares outstanding as a

result of the Acquisition. The following table summarizes the computation of the unaudited pro forma basic and diluted net income per share:

(in millions, except per share data)

Six months ended

Year ended

June 30, 2026

December 31, 2025

Pro forma net income - basic and diluted

294.0

324.5

Weighted-average common shares outstanding:

Basic

100.8

99.5

Effect of dilutive securities

3.0

Diluted

103.8

102.5

Pro forma earnings per share:

Basic

2.92

3.26

Diluted

2.83

3.17

Shares excluded from diluted per share amounts because their effect would have been

anti-dilutive

4.5

4.0

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