Form 8-K
8-K — BriaCell Therapeutics Corp.
Accession: 0001493152-26-026953
Filed: 2026-06-03
Period: 2026-05-31
CIK: 0001610820
SIC: 2834 (PHARMACEUTICAL PREPARATIONS)
Item: Entry into a Material Definitive Agreement
Item: Unregistered Sales of Equity Securities
Item: Other Events
Item: Financial Statements and Exhibits
Documents
8-K — form8-k.htm (Primary)
EX-4.1 (ex4-1.htm)
EX-5.1 (ex5-1.htm)
EX-10.1 (ex10-1.htm)
EX-99.1 (ex99-1.htm)
EX-99.2 (ex99-2.htm)
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GRAPHIC (ex5-1_002.jpg)
GRAPHIC (ex5-1_003.jpg)
GRAPHIC (ex99-1_001.jpg)
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2026-05-31
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2026-05-31
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UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
WASHINGTON,
D.C. 20549
FORM
8-K
CURRENT
REPORT
PURSUANT
TO SECTION 13 OR 15(d) OF THE
SECURITIES
EXCHANGE ACT OF 1934
Date
of Report (Date of earliest event reported): May 31, 2026
BRIACELL
THERAPEUTICS CORP.
(Exact
name of registrant as specified in its charter)
British
Columbia A1
47-1099599
(State
or other jurisdiction
of
incorporation or organization)
(I.R.S.
Employer
Identification
No.)
Suite
300 - 235 15th Street
West
Vancouver, BC V7T 2X1
V7T
2X1
(Address
of principal executive offices)
(Zip
Code)
(604)
921-1810
(Registrant’s
telephone number, including area code)
Commission
File No. 001-40101
Check
the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under
any of the following provisions (see General Instruction A.2. below):
☐
Written
communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
☐
Soliciting
material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
☐
Pre-commencement
communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
☐
Pre-commencement
communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Securities
registered under Section 12(b) of the Act:
Title
of each class
Trading
Symbol(s)
Name
of each exchange on which registered
Common
Shares, no par value
BCTX
The
Nasdaq Stock Market LLC
Warrants
to purchase common shares, no par value
BCTXL
and BCTXZ
The
Nasdaq Stock Market LLC
Indicate
by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405)
or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2).
Emerging
growth company ☒
If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Item
1.01 Entry into a Material Definitive Agreement.
On
May 31, 2026, BriaCell Therapeutics Corp. (the “Company”) entered into a Placement Agency Agreement (the “Agreement”)
with ThinkEquity LLC (the “Placement Agent”), pursuant to which the Company agreed to issue and sell directly to investors,
in a best efforts offering (the “Offering”), an aggregate of 1,449,300 common shares of the Company at an offering price
of $3.25 per common share.
The
Offering closed on June 2, 2025. The Company received gross proceeds of $4.71 million in connection with the Offering, before deducting
Placement Agent fees and other Offering expenses payable by the Company. The Company intends to use the net proceeds from the Offering
for working capital requirements, general corporate purposes, and the advancement of business objectives.
The
1,449,300 common shares sold in the Offering were offered and sold pursuant to a registration statement on Form S-3 (File No. 333-276650),
which was filed with the Securities and Exchange Commission (the “Commission”) on January 22, 2024, and was declared effective
by the Commission on January 31, 2024. A prospectus supplement and the accompanying prospectus relating to the Offering have been filed
with the Commission.
As
part of its compensation for acting as Placement Agent for the Offering, the Company paid the Placement Agent a cash fee of 7.5% of the
aggregate gross proceeds and also issued to the Placement Agent warrants to purchase 72,465 common shares (the “Placement Agent
Warrants”). The Placement Agent Warrants are exercisable upon issuance, expire five years from the date of the Agreement, and have
an exercise price of $4.0625 per common share. The Placement Agent Warrants, and the common shares issuable upon exercise thereof, were
issued in reliance on the exemption from registration provided in Section 4(a)(2) under the Securities Act of 1933, as amended, for transactions
not involving a public offering.
The
representations, warranties and covenants contained in the Agreement were made solely for the benefit of the parties to the Agreement.
In addition, such representations, warranties and covenants (i) are intended as a way of allocating the risk between the parties to the
Agreement and not as statements of fact, and (ii) may apply standards of materiality in a way that is different from what may be viewed
as material by stockholders of, or other investors in, the Company. Moreover, information concerning the subject matter of the representations
and warranties may change after the date of the Agreement, which subsequent information may or may not be fully reflected in public disclosures.
This
Current Report on Form 8-K shall not constitute an offer to sell or the solicitation of an offer to buy securities, nor shall there be
any sale of securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration
or qualification under the securities laws of any such state or other jurisdiction.
The
foregoing descriptions of the Placement Agent Warrants and Agreement are not complete and are qualified in their entirety by references
to the full text of the form of Placement Agent Warrant and Agreement which are filed as Exhibit 4.1 and Exhibit 10.1, respectively,
to this Current Report on Form 8-K and are incorporated herein by reference.
The
Canadian legal opinion, including the related consent, of Bennett Jones LLP relating to the issuance and sale of the common shares is
filed as Exhibit 5.1 hereto.
Item
3.02 Unregistered Sales of Equity Securities.
The
disclosure set forth in Item 1.01 of this Current Report on Form 8-K regarding the Placement Agent Warrants and the shares issuable thereunder
are hereby incorporated by reference.
Item
8.01 Other Events.
On
May 31, 2026, the Company issued a press release announcing the pricing of the Offering.
On
June 2, 2026, the Company issued a press release announcing the closing of the Offering.
Copies
of the press releases are attached as Exhibits 99.1 and 99.2 respectively, to this Current Report on Form 8-K and are incorporated herein
by reference.
Item
9.01 Financial Statements and Exhibits.
(d)
Exhibits
Exhibit
No.
Description
4.1
Form of Placement Agent Warrant
5.1
Opinion of Bennett Jones LLP
10.1
Placement Agency Agreement
23.1
Consent of Bennett Jones LLP (included in Exhibit 5.1)
99.1
Pricing Press Release dated May 31, 2026
99.2
Closing Press Release dated June 2, 2026
104
Cover
Page Interactive Data File (embedded within the Inline XBRL document)
SIGNATURES
Pursuant
to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by
the undersigned hereunto duly authorized.
BRIACELL
THERAPEUTICS CORP.
/s/
William V. Williams
June
2, 2026
William
V. Williams
President
and Chief Executive Officer
EX-4.1
EX-4.1
Filename: ex4-1.htm · Sequence: 2
Exhibit
4.1
FORM
OF PLACEMENT AGENT’S WARRANT
BRIACELL
THERAPEUTICS CORP.
Warrant
Shares: _____
Initial
Exercise Date: June 2, 2026
THIS
WARRANT TO PURCHASE COMMON SHARES (the “Warrant”) certifies that, for value received, ________ or its assigns (the
“Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set
forth, at any time on or after June 2, 2026 (the “Initial Exercise Date”) and, in accordance with FINRA Rule 5110(g)(8)(A),
prior to 5:00 p.m. (New York time) on the date that is five (5) years following the Effective Date (the “Termination Date”)
but not thereafter, to subscribe for and purchase from BriaCell Therapeutics Corp., a British Columbia corporation (the “Company”),
up to ____ Common Shares, without par value per share, of the Company (the “Warrant Shares”), as subject to adjustment
hereunder. The purchase price of one Common Share under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).
Section
1. Definitions. In addition to the terms defined elsewhere in this Agreement, the following terms have the meanings indicated
in this Section 1:
“Affiliate”
means any Person that, directly or indirectly through one or more intermediaries, controls or is controlled by or is under common control
with a Person, as such terms are used in and construed under Rule 405 under the Securities Act.
“Business
Day” means any day except any Saturday, any Sunday, any day which is a federal legal holiday in the United States or any day
on which banking institutions in the State of New York are authorized or required by law or other governmental action to close.
“Commission”
means the United States Securities and Exchange Commission.
“Common
Shares” means the common shares of the Company, no par value per share, and any other class of securities into which such securities
may hereafter be reclassified or changed.
“Common
Share Equivalents” means any securities of the Company or its subsidiaries which would entitle the holder thereof to acquire
at any time Common Shares, including, without limitation, any debt, preferred shares, right, option, warrant or other instrument that
is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive, Common Shares.
“Effective
Date” means May 31, 2026.
“Exchange
Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.
“Person”
means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.
“Rule
144” means Rule 144 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended or interpreted
from time to time, or any similar rule or regulation hereafter adopted by the Commission having substantially the same purpose and effect
as such Rule.
“Securities
Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.
“Trading
Day” means a day on which the Nasdaq Capital Market is open for trading.
“Trading
Market” means any of the following markets or exchanges on which the Common Shares are listed or quoted for trading on the
date in question: the NYSE MKT, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, or the New York
Stock Exchange (or any successors to any of the foregoing).
“VWAP”
means, for any date, the price determined by the first of the following clauses that applies: (a) if the Common Shares are then listed
or quoted on a Trading Market, the daily volume weighted average price by total trading volume of the Common Shares for such date (or
the nearest preceding date) on the Trading Market on which the Common Shares are then listed or quoted as reported by Bloomberg L.P.
(based on a Trading Day from 9:30 a.m. (New York City time) to 4:02 p.m. (New York City time)), (b) if OTCQB or OTCQX is not a Trading
Market, the volume weighted average price by total trading volume of a Common Share for such date (or the nearest preceding date) on
the OTCQB or OTCQX as applicable, (c) if the Common Shares are not then listed or quoted for trading on the OTCQB or OTCQX and if prices
for Common Shares are then reported in the “Pink Sheets” published by OTC Markets Group, Inc. (or a similar organization
or agency succeeding to its functions of reporting prices), the most recent bid price per Common Share so reported, or (d) in all other
cases, the fair market value of the Common Shares as determined by an independent appraiser selected in good faith by the Holder and
reasonably acceptable to the Company, the fees and expenses of which shall be paid by the Company.
Section
2. Exercise.
a)
Exercise of the purchase rights represented by this Warrant may be made, in whole or in part, at any time or times on or after the Initial
Exercise Date and on or before the Termination Date by delivery to the Company (or such other office or agency of the Company as it may
designate by notice in writing to the registered Holder at the address of the Holder appearing on the books of the Company) of a duly
executed facsimile copy (or e-mail attachment) of the Notice of Exercise Form annexed hereto. Within one (1) Trading Day following the
date of exercise as aforesaid, the Holder shall deliver the aggregate Exercise Price for the shares specified in the applicable Notice
of Exercise by wire transfer or cashier’s check drawn on a United States bank unless the cashless exercise procedure specified
in Section 2(c) below is specified in the applicable Notice of Exercise. No ink-original Notice of Exercise shall be required, nor shall
any medallion guarantee (or other type of guarantee or notarization) of any Notice of Exercise form be required. Notwithstanding anything
herein to the contrary, the Holder shall not be required to physically surrender this Warrant to the Company until the Holder has purchased
all of the Warrant Shares available hereunder and the Warrant has been exercised in full, in which case, the Holder shall surrender this
Warrant to the Company for cancellation within five (5) Trading Days of the date the final Notice of Exercise is delivered to the Company.
Partial exercises of this Warrant resulting in purchases of a portion of the total number of Warrant Shares available hereunder shall
have the effect of lowering the outstanding number of Warrant Shares purchasable hereunder in an amount equal to the applicable number
of Warrant Shares purchased. The Holder and the Company shall maintain records showing the number of Warrant Shares purchased and the
date of such purchases. The Company shall deliver any objection to any Notice of Exercise Form within one (1) Business Day of receipt
of such notice. The Holder and any assignee, by acceptance of this Warrant, acknowledge and agree that, by reason of the provisions
of this paragraph, following the purchase of a portion of the Warrant Shares hereunder, the number of Warrant Shares available for purchase
hereunder at any given time may be less than the amount stated on the face hereof.
b)
Exercise Price. The exercise price per Common Share under this Warrant shall be US$4.0625, subject to adjustment hereunder
(the “Exercise Price”).
c)
Cashless Exercise. In lieu of exercising this Warrant by delivering the aggregate Exercise Price by wire transfer or cashier’s
check, at the election of the Holder this Warrant may also be exercised, in whole or in part, at such time by means of a “cashless
exercise” in which the Holder shall be entitled to receive the number of Warrant Shares equal to the quotient obtained by dividing
[(A-B) (X)] by (A), where:
(A)
=
as
applicable: (i) the VWAP for the five Trading Days immediately preceding the date of the applicable Notice of Exercise if such Notice
of Exercise is (1) both executed and delivered pursuant to Section 2(a) hereof on a day that is not a Trading Day or (2) both executed
and delivered pursuant to Section 2(a) hereof on a Trading Day prior to the opening of “regular trading hours” (as defined
in Rule 600(b)(64) of Regulation NMS promulgated under the federal securities laws) on such Trading Day, (ii) the VWAP for the five
Trading Days immediately preceding the date of the applicable Notice of Exercise if such Notice of Exercise is executed during “regular
trading hours” on a Trading Day and is delivered within two (2) hours thereafter (including until two (2) hours after the close
of “regular trading hours” on a Trading Day) pursuant to Section 2(a) hereof or (iii) the VWAP for the five Trading Days
immediately preceding the applicable Notice of Exercise if the date of such Notice of Exercise is a Trading Day and such Notice of
Exercise is both executed and delivered pursuant to Section 2(a) hereof after the close of “regular trading hours” on
such Trading Day;
(B)
=
the
Exercise Price of this Warrant, as adjusted hereunder; and
(X)
=
the
number of Warrant Shares that would be issuable upon exercise of this Warrant in accordance with the terms of this Warrant if such
exercise were by means of a cash exercise rather than a cashless exercise.
If
Warrant Shares are issued in such a “cashless exercise,” the parties acknowledge and agree that in accordance with Section
3(a)(9) of the Securities Act, the Warrant Shares shall take on the registered characteristics of the Warrants being exercised, and the
holding period of the Warrants being exercised may be tacked on to the holding period of the Warrant Shares. The Company agrees not to
take any position contrary to this Section 2(c).
Notwithstanding
anything herein to the contrary, on the Termination Date, this Warrant shall be automatically exercised via cashless exercise pursuant
to this Section 2(c).
d)
Mechanics of Exercise.
i.
Delivery of Warrant Shares Upon Exercise. The Company shall cause the Warrant Shares purchased hereunder to be transmitted by
its transfer agent to the Holder by crediting the account of the Holder’s or its designee’s balance account with The Depository
Trust Company through its Deposit or Withdrawal at Custodian system (“DWAC”) if the Company is then a participant
in such system and either (A) there is an effective registration statement permitting the issuance of the Warrant Shares to or resale
of the Warrant Shares by Holder, or (B) the Warrant Shares are eligible for resale by the Holder without volume or manner-of-sale limitations
pursuant to Rule 144 and, in either case, the Warrant Shares have been sold by the Holder prior to the Warrant Share Delivery Date (as
defined below), and otherwise by physical delivery of a certificate, registered in the Company’s share register in the name of
the Holder or its designee, for the number of Warrant Shares to which the Holder is entitled pursuant to such exercise to the address
specified by the Holder in the Notice of Exercise by the date that is one (1) Trading Day after the delivery to the Company of the Notice
of Exercise (such date, the “Warrant Share Delivery Date”). If the Warrant Shares can be delivered via DWAC, the transfer
agent shall have received from the Company, at the expense of the Company, any legal opinions or other documentation required by it to
deliver such Warrant Shares without legend (subject to receipt by the Company of reasonable back up documentation from the Holder, including
with respect to affiliate status) and, if applicable and requested by the Company prior to the Warrant Share Delivery Date, the transfer
agent shall have received from the Holder a confirmation of sale of the Warrant Shares (provided the requirement of the Holder to provide
a confirmation as to the sale of Warrant Shares shall not be applicable to the issuance of unlegended Warrant Shares upon a cashless
exercise of this Warrant if the Warrant Shares are then eligible for resale pursuant to Rule 144(b)(1)). The Warrant Shares shall be
deemed to have been issued, and Holder or any other person so designated to be named therein shall be deemed to have become a holder
of record of such shares for all purposes, as of the date the Warrant has been exercised, with payment to the Company of the Exercise
Price (or by cashless exercise, if permitted) and all taxes required to be paid by the Holder, if any, pursuant to Section 2(d)(vi) prior
to the issuance of such shares, having been paid. If the Company fails for any reason to deliver to the Holder the Warrant Shares subject
to a Notice of Exercise by the Trading Day following the Warrant Share Delivery Date, the Company shall pay to the Holder, in cash, as
liquidated damages and not as a penalty, for each US$1,000 of Warrant Shares subject to such exercise (based on the VWAP of the Common
Shares on the date of the applicable Notice of Exercise), US$10 per Trading Day (increasing to US$20 per Trading Day on the second Trading
Day after such liquidated damages begin to accrue) for each Trading Day after the second Trading Day following such Warrant Share Delivery
Date until such Warrant Shares are delivered or Holder rescinds such exercise.
ii.
Delivery of New Warrants Upon Exercise. If this Warrant shall have been exercised in part, the Company shall, at the request of
a Holder and upon surrender of this Warrant certificate, at the time of delivery of the Warrant Shares, deliver to the Holder a new Warrant
evidencing the rights of the Holder to purchase the unpurchased Warrant Shares called for by this Warrant, which new Warrant shall in
all other respects be identical with this Warrant.
iii.
Rescission Rights. If the Company fails to cause its transfer agent to deliver to the Holder the Warrant Shares pursuant to Section
2(d)(i) by the Warrant Share Delivery Date (for avoidance of doubt, other than any such failure that is due solely to any action or inaction
by the Holder), then the Holder will have the right to rescind such exercise; provided, however, that the Holder shall
be required to return any Warrant Shares or Common Shares subject to any such rescinded exercise notice concurrently with the return
to Holder of the aggregate Exercise Price paid to the Company for such Warrant Shares and the restoration of Holder’s right to
acquire such Warrant Shares pursuant to this Warrant (including, issuance of a replacement warrant certificate evidencing such restored
right).
iv.
Compensation for Buy-In on Failure to Timely Deliver Warrant Shares Upon Exercise. In addition to any other rights available to
the Holder, if the Company fails to cause its transfer agent to transmit to the Holder the Warrant Shares pursuant to an exercise on
or before the Warrant Share Delivery Date, and if after such date the Holder is required by its broker to purchase (in an open market
transaction or otherwise) or the Holder’s brokerage firm otherwise purchases, Common Shares to deliver in satisfaction of a sale
by the Holder of the Warrant Shares which the Holder anticipated receiving upon such exercise (a “Buy-In”), then the
Company shall (A) pay in cash to the Holder the amount, if any, by which (x) the Holder’s total purchase price (including brokerage
commissions, if any) for the Common Shares so purchased exceeds (y) the amount obtained by multiplying (1) the number of Warrant Shares
that the Company was required to deliver to the Holder in connection with the exercise at issue times (2) the price at which the sell
order giving rise to such purchase obligation was executed, and (B) at the option of the Holder, either reinstate the portion of the
Warrant and equivalent number of Warrant Shares for which such exercise was not honored (in which case such exercise shall be deemed
rescinded) or deliver to the Holder the number of Common Shares that would have been issued had the Company timely complied with its
exercise and delivery obligations hereunder. For example, if the Holder purchases Common Shares having a total purchase price of US$11,000
to cover a Buy-In with respect to an attempted exercise of Common Shares with an aggregate sale price giving rise to such purchase obligation
of US$10,000, under clause (A) of the immediately preceding sentence the Company shall be required to pay the Holder US$1,000. The Holder
shall provide the Company written notice indicating the amounts payable to the Holder in respect of the Buy-In and, upon request of the
Company, evidence of the amount of such loss. Nothing herein shall limit a Holder’s right to pursue any other remedies available
to it hereunder, at law or in equity including, without limitation, a decree of specific performance and/or injunctive relief with respect
to the Company’s failure to timely deliver Common Shares upon exercise of the Warrant as required pursuant to the terms hereof.
v.
No Fractional Shares or Scrip. No fractional shares or scrip representing fractional shares shall be issued upon the exercise
of this Warrant. As to any fraction of a share which the Holder would otherwise be entitled to purchase upon such exercise, the Company
shall, at its election, either pay a cash adjustment in respect of such final fraction in an amount equal to such fraction multiplied
by the Exercise Price or round up to the next whole share.
vi.
Charges, Taxes and Expenses. Issuance of Warrant Shares shall be made without charge to the Holder for any issue or transfer tax
or other incidental expense in respect of the issuance of such Warrant Shares, all of which taxes and expenses shall be paid by the Company,
and such Warrant Shares shall be issued in the name of the Holder or in such name or names as may be directed by the Holder; provided,
however, that in the event that Warrant Shares are to be issued in a name other than the name of the Holder, this Warrant when
surrendered for exercise shall be accompanied by the Assignment Form attached hereto duly executed by the Holder and the Company may
require, as a condition thereto, the payment of a sum sufficient to reimburse it for any transfer tax incidental thereto. The Company
shall pay all transfer agent fees required for same-day processing of any Notice of Exercise and all fees to the Depository Trust Company
(or another established clearing corporation performing similar functions) required for same-day electronic delivery of the Warrant Shares.
vii.
Closing of Books. The Company will not close its shareholder books or records in any manner which prevents the timely exercise
of this Warrant, pursuant to the terms hereof.
viii.
Signature. This Section 2 and the exercise form attached hereto set forth the totality of the procedures required of the Holder
in order to exercise this Warrant. Without limiting the preceding sentences, no ink-original exercise form shall be required, nor shall
any medallion guarantee (or other type of guarantee or notarization) of any exercise form be required in order to exercise this Warrant.
No additional legal opinion, other information or instructions shall be required of the Holder to exercise this Warrant. The Company
shall honor exercises of this Warrant and shall deliver Shares underlying this Warrant in accordance with the terms, conditions and time
periods set forth herein.
e) Holder’s Exercise Limitations. The Company shall not effect any exercise of this Warrant, and a Holder shall not have the right to exercise any portion of this Warrant, pursuant to Section 2 or otherwise, to the extent that after giving effect to such issuance after exercise as set forth on the applicable Notice of Exercise, the Holder (together with the Holder’s Affiliates, and any other Persons acting as a group together with the Holder or any of the Holder’s Affiliates), would beneficially own in excess of the Beneficial Ownership Limitation (as defined below). For purposes of the foregoing sentence, the number of Common Shares beneficially owned by the Holder and its Affiliates shall include the number of Common Shares issuable upon exercise of this Warrant with respect to which such determination is being made, but shall exclude the number of Common Shares which would be issuable upon (i) exercise of the remaining, nonexercised portion of this Warrant beneficially owned by the Holder or any of its Affiliates and (ii) exercise or conversion of the unexercised or nonconverted portion of any other securities of the Company (including, without limitation, any other Common Share Equivalents) subject to a limitation on conversion or exercise analogous to the limitation contained herein beneficially owned by the Holder or any of its Affiliates. Except as set forth in the preceding sentence, for purposes of this Section 2(e), beneficial ownership shall be calculated in accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder, it being acknowledged by the Holder that the Company is not representing to the Holder that such calculation is in compliance with Section 13(d) of the Exchange Act and the Holder is solely responsible for any schedules required to be filed in accordance therewith. To the extent that the limitation contained in this Section 2(e) applies, the determination of whether this Warrant is exercisable (in relation to other securities owned by the Holder together with any Affiliates) and of which portion of this Warrant is exercisable shall be in the sole discretion of the Holder, and the submission of a Notice of Exercise shall be deemed to be the Holder’s determination of whether this Warrant is exercisable (in relation to other securities owned by the Holder together with any Affiliates) and of which portion of this Warrant is exercisable, in each case subject to the Beneficial Ownership Limitation, and the Company shall have no obligation to verify or confirm the accuracy of such determination. In addition, a determination as to any group status as contemplated above shall be determined in accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder. For purposes of this Section 2(e), in determining the number of outstanding Common Shares, a Holder may rely on the number of outstanding Common Shares as reflected in (A) the Company’s most recent periodic or annual report filed with the Commission, as the case may be, (B) a more recent public announcement by the Company or (C) a more recent written notice by the Company or the Company’s transfer agent setting forth the number of Common Shares outstanding. Upon the written or oral request of a Holder, the Company shall within one Trading Day confirm orally and in writing to the Holder the number of Common Shares then outstanding. In any case, the number of outstanding Common Shares shall be determined after giving effect to the conversion or exercise of securities of the Company, including this Warrant, by the Holder or its Affiliates since the date as of which such number of outstanding Common Shares was reported. The “Beneficial Ownership Limitation” shall be 9.99% of the number of Common Shares outstanding immediately after giving effect to the issuance of Common Shares issuable upon exercise of this Warrant. The Holder, upon notice to the Company, may increase or decrease the Beneficial Ownership Limitation provisions of this Section 2(e), provided that the Beneficial Ownership Limitation in no event exceeds 9.99% of the number of Common Shares outstanding immediately after giving effect to the issuance of Common Shares upon exercise of this Warrant held by the Holder and the provisions of this Section 2(e) shall continue to apply. Any increase in the Beneficial Ownership Limitation will not be effective until the 61st day after such notice is delivered to the Company. The provisions of this paragraph shall be construed and implemented in a manner otherwise than in strict conformity with the terms of this Section 2(e) to correct this paragraph (or any portion hereof) which may be defective or inconsistent with the intended Beneficial Ownership Limitation herein contained or to make changes or supplements necessary or desirable to properly give effect to such limitation. The limitations contained in this paragraph shall apply to a successor holder of this Warrant.
Section
3. Certain Adjustments.
a)
Stock Dividends and Splits. If the Company, at any time while this Warrant is outstanding: (i) pays a stock dividend or otherwise
makes a distribution or distributions on its Common Shares or any other equity or equity equivalent securities payable in Common Shares
(which, for avoidance of doubt, shall not include any Common Shares issued by the Company upon exercise of this Warrant), (ii) subdivides
outstanding Common Shares into a larger number of shares, (iii) combines (including by way of reverse stock or share split) outstanding
Common Shares into a smaller number of shares, or (iv) issues by reclassification of Common Shares any shares of capital stock of the
Company, then in each case the Exercise Price shall be multiplied by a fraction of which the numerator shall be the number of Common
Shares (excluding treasury shares, if any) outstanding immediately before such event and of which the denominator shall be the number
of Common Shares outstanding immediately after such event, and the number of shares issuable upon exercise of this Warrant shall be proportionately
adjusted such that the aggregate Exercise Price of this Warrant shall remain unchanged. Any adjustment made pursuant to this Section
3(a) shall become effective immediately after the record date for the determination of shareholders entitled to receive such dividend
or distribution and shall become effective immediately after the effective date in the case of a subdivision, combination or re-classification.
For the purposes of clarification, the Exercise Price of this Warrant will not be adjusted in the event that the Company or any Subsidiary
thereof, as applicable, sells or grants any option to purchase, or sell or grant any right to reprice, or otherwise dispose of or issue
(or announce any offer, sale, grant or any option to purchase or other disposition) any Common Shares or Common Share Equivalents, at
an effective price per share less than the Exercise Price then in effect.
b) [RESERVED]
c)
Subsequent Rights Offerings. In addition to any adjustments pursuant to Section 3(a) above, subject to the prior approval of the
TSX (as long as the Common Shares are listed for trading on the TSX), if at any time the Company grants, issues or sells any Common Share
Equivalents or rights to purchase shares, warrants, securities or other property pro rata to the record holders of any class of Common
Shares (the “Purchase Rights”), then the Holder will be entitled to acquire, upon the terms applicable to such Purchase
Rights, the aggregate Purchase Rights which the Holder could have acquired if the Holder had held the number of Common Shares acquirable
upon complete exercise of this Warrant (without regard to any limitations on exercise hereof, including without limitation, the Beneficial
Ownership Limitation) immediately before the date on which a record is taken for the grant, issuance or sale of such Purchase Rights,
or, if no such record is taken, the date as of which the record holders of Common Shares are to be determined for the grant, issue or
sale of such Purchase Rights (provided, however, to the extent that the Holder’s right to participate in any such Purchase Right
would result in the Holder exceeding the Beneficial Ownership Limitation, then the Holder shall not be entitled to participate in such
Purchase Right to such extent (or beneficial ownership of such Common Shares as a result of such Purchase Right to such extent) and such
Purchase Right to such extent shall be held in abeyance for the Holder until such time, if ever, as its right thereto would not result
in the Holder exceeding the Beneficial Ownership Limitation).
d)
Pro Rata Distributions. During such time as this Warrant is outstanding, if the Company shall declare or make any dividend (other
than cash dividends) or other distribution of its assets (or rights to acquire its assets) to holders of Common Shares, by way of return
of capital or otherwise (including, without limitation, any distribution of shares or other securities, property or options by way of
a dividend, spin off, reclassification, corporate rearrangement, scheme of arrangement or other similar transaction) (a “Distribution”),
at any time after the issuance of this Warrant, then, in each such case, the Holder shall be entitled to participate in such Distribution
to the same extent that the Holder would have participated therein if the Holder had held the number of Common Shares acquirable upon
complete exercise of this Warrant (without regard to any limitations on exercise hereof, including without limitation, the Beneficial
Ownership Limitation) immediately before the date of which a record is taken for such Distribution, or, if no such record is taken, the
date as of which the record holders of Common Shares are to be determined for the participation in such Distribution (provided,
however, to the extent that the Holder’s right to participate in any such Distribution would result in the Holder exceeding
the Beneficial Ownership Limitation, then the Holder shall not be entitled to participate in such Distribution to such extent (or in
the beneficial ownership of any Common Shares as a result of such Distribution to such extent) and the portion of such Distribution shall
be held in abeyance for the benefit of the Holder until such time, if ever, as its right thereto would not result in the Holder exceeding
the Beneficial Ownership Limitation). To the extent that this Warrant has not been partially or completely exercised at the time of such
Distribution, such portion of the Distribution shall be held in abeyance for the benefit of the Holder until the Holder has exercised
this Warrant.
e) Fundamental
Transaction. If, at any time while this Warrant is outstanding, (i) the Company, directly or indirectly, in one or more related
transactions effects any merger, amalgamation, arrangement or consolidation of the Company with or into another Person, (ii) the
Company, directly or indirectly, effects any sale, lease, license, assignment, transfer, conveyance or other disposition of all or
substantially all of its assets in one or a series of related transactions, (iii) any, direct or indirect, purchase offer, tender
offer or exchange offer (whether by the Company or another Person) is completed pursuant to which holders of Common Shares are
permitted to sell, tender or exchange their shares for other securities, cash or property and has been accepted by the holders of
50% or more of the outstanding Common Shares, (iv) the Company, directly or indirectly, in one or more related transactions effects
any reclassification, reorganization or recapitalization of the Common Shares or any compulsory share exchange pursuant to which the
Common Shares are effectively converted into or exchanged for other securities, cash or property, or (v) the Company, directly or
indirectly, in one or more related transactions consummates a stock or share purchase agreement or other business combination
(including, without limitation, a reorganization, recapitalization, spin-off or scheme of arrangement) with another Person or group
of Persons whereby such other Person or group acquires more than 50% of the outstanding Common Shares (not including any Common
Shares held by the other Person or other Persons making or party to, or associated or affiliated with the other Persons making or
party to, such stock or share purchase agreement or other business combination) (each a “Fundamental
Transaction”), then, upon any subsequent exercise of this Warrant, the Holder shall have the right to receive, for each
Warrant Share that would have been issuable upon such exercise immediately prior to the occurrence of such Fundamental Transaction,
at the option of the Holder (without regard to any limitation in Section 2(e) on the exercise of this Warrant), the number of Common
Shares of the successor or acquiring corporation or of the Company, if it is the surviving corporation or is otherwise the
continuing corporation, and any additional consideration (the “Alternate Consideration”) receivable by holders of
Common Shares as a result of such Fundamental Transaction for each Common Share for which this Warrant is exercisable immediately
prior to such Fundamental Transaction (without regard to any limitation in Section 2(e) on the exercise of this Warrant). For
purposes of any such exercise, the determination of the Exercise Price shall be appropriately adjusted to apply to such Alternate
Consideration based on the amount of Alternate Consideration issuable in respect of one Common Share in such Fundamental
Transaction, and the Company shall apportion the Exercise Price among the Alternate Consideration in a reasonable manner reflecting
the relative value of any different components of the Alternate Consideration. If holders of Common Shares are given any choice as
to the securities, cash or property to be received in a Fundamental Transaction, then the Holder shall be given the same choice as
to the Alternate Consideration it receives upon any exercise of this Warrant following such Fundamental Transaction. The Company
shall cause any successor entity in a Fundamental Transaction in which the Company is not the survivor (the “Successor
Entity”) to assume in writing all of the obligations of the Company under this Warrant in accordance with the provisions
of this Section 3(e) pursuant to written agreements in form and substance reasonably satisfactory to the Holder and approved by the
Holder (without unreasonable delay) prior to such Fundamental Transaction and shall, at the option of the Holder, deliver to the
Holder in exchange for this Warrant a security of the Successor Entity evidenced by a written instrument substantially similar in
form and substance to this Warrant which is exercisable for a corresponding number of shares of capital stock of such Successor
Entity (or its parent entity) equivalent to the Common Shares acquirable and receivable upon exercise of this Warrant (without
regard to any limitations on the exercise of this Warrant) prior to such Fundamental Transaction, and with an exercise price which
applies the exercise price hereunder to such shares of capital stock (but taking into account the relative value of the Common
Shares pursuant to such Fundamental Transaction and the value of such shares of capital stock, such number of shares of capital
stock and such exercise price being for the purpose of protecting the economic value of this Warrant immediately prior to the
consummation of such Fundamental Transaction), and which is reasonably satisfactory in form and substance to the Holder. Upon the
occurrence of any such Fundamental Transaction, the Successor Entity shall succeed to, and be substituted for (so that from and
after the date of such Fundamental Transaction, the provisions of this Warrant referring to the “Company” shall refer
instead to the Successor Entity), and may exercise every right and power of the Company and shall assume all of the obligations of
the Company under this Warrant with the same effect as if such Successor Entity had been named as the Company herein.
f)
Calculations. All calculations under this Section 3 shall be made to the nearest cent or the nearest 1/100th of a share, as the
case may be. For purposes of this Section 3, the number of Common Shares deemed to be issued and outstanding as of a given date shall
be the sum of the number of Common Shares (excluding treasury shares, if any) issued and outstanding.
g) Notice to Holder.
i.
Adjustment to Exercise Price. Whenever the Exercise Price is adjusted pursuant to any provision of this Section 3, the Company
shall promptly mail to the Holder a notice setting forth the Exercise Price after such adjustment and any resulting adjustment to the
number of Warrant Shares and setting forth a brief statement of the facts requiring such adjustment.
ii. Notice
to Allow Exercise by Holder. If (A) the Company shall declare a dividend (or any other distribution in whatever form) on the
Common Shares, (B) the Company shall declare a special nonrecurring cash dividend on or a redemption of the Common Shares, (C) the
Company shall authorize the granting to all holders of the Common Shares rights or warrants to subscribe for or purchase any shares
of capital stock of any class or of any rights, (D) the approval of any shareholders of the Company shall be required in connection
with any reclassification of the Common Shares, any consolidation, merger, amalgamation or arrangement to which the Company is a
party, any sale or transfer of all or substantially all of the assets of the Company, or any compulsory share exchange whereby the
Common Shares are converted into other securities, cash or property, or (E) the Company shall authorize the voluntary or involuntary
dissolution, liquidation or winding up of the affairs of the Company, then, in each case, the Company shall cause to be mailed a
notice to the Holder at its last address as it shall appear upon the Warrant Register of the Company, at least 20 calendar days
prior to the applicable record or effective date hereinafter specified, stating (x) the date on which a record is to be taken for
the purpose of such dividend, distribution, redemption, rights or warrants, or if a record is not to be taken, the date as of which
the holders of the Common Shares of record to be entitled to such dividend, distributions, redemption, rights or warrants are to be
determined or (y) the date on which such reclassification, consolidation, merger, amalgamation, arrangement, sale, transfer or share
exchange is expected to become effective or close, and the date as of which it is expected that holders of the Common Shares of
record shall be entitled to exchange their Common Shares for securities, cash or other property deliverable upon such
reclassification, consolidation, merger, amalgamation, arrangement, sale, transfer or share exchange; provided that the failure to
provide such notice or any defect therein shall not affect the validity of the corporate action required to be specified in such
notice. To the extent that any notice provided hereunder constitutes, or contains, material, non-public information regarding the
Company or any of the Subsidiaries, the Company shall simultaneously file such notice with the Commission pursuant to a Current
Report on Form 8-K. The Holder shall remain entitled to exercise this Warrant during the period commencing on the date of such
notice to the effective date of the event triggering such notice except as may otherwise be expressly set forth herein.
Section
4. Transfer of Warrant.
a)
Transferability. Subject to any applicable securities laws and the conditions set forth in Section 4(d), this Warrant and all
rights hereunder (including, without limitation, any registration rights) are transferable, in whole or in part, upon surrender of this
Warrant at the principal office of the Company or its designated agent, together with a written assignment of this Warrant substantially
in the form attached hereto duly executed by the Holder or its agent or attorney and funds sufficient to pay any transfer taxes payable
upon the making of such transfer. Upon such surrender and, if required, such payment, the Company shall execute and deliver a new Warrant
or Warrants in the name of the assignee or assignees, as applicable, and in the denomination or denominations specified in such instrument
of assignment, and shall issue to the assignor a new Warrant evidencing the portion of this Warrant not so assigned, and this Warrant
shall promptly be cancelled. Notwithstanding anything herein to the contrary, the Holder shall not be required to physically surrender
this Warrant to the Company unless the Holder has assigned this Warrant in full, in which case, the Holder shall surrender this Warrant
to the Company within three (3) Trading Days of the date the Holder delivers an assignment form to the Company assigning this Warrant
full. The Warrant, if properly assigned in accordance herewith, may be exercised by a new holder for the purchase of Warrant Shares without
having a new Warrant issued.
Notwithstanding
the foregoing or anything to the contrary in this Warrant, so long as the Common Shares are listed on the Toronto Stock Exchange (the
“TSX”), this Warrant may not be sold, transferred, assigned, pledged, or hypothecated, or be the subject of any hedging,
short sale, derivative, put, or call transaction that would result in the effective economic disposition of the securities, to any person
other than an affiliate or employee (or an affiliate of such employee) of ThinkEquity LLC within the meaning of the policies of the TSX.
b)
New Warrants. This Warrant may be divided or combined with other Warrants upon presentation hereof at the aforesaid office of
the Company, together with a written notice specifying the names and denominations in which new Warrants are to be issued, signed by
the Holder or its agent or attorney. Subject to compliance with Section 4(a), as to any transfer which may be involved in such division
or combination, the Company shall execute and deliver a new Warrant or Warrants in exchange for the Warrant or Warrants to be divided
or combined in accordance with such notice. All Warrants issued on transfers or exchanges shall be dated the initial issuance date of
this Warrant and shall be identical with this Warrant except as to the number of Warrant Shares issuable pursuant thereto.
c)
Warrant Register. The Company shall register this Warrant, upon records to be maintained by the Company for that purpose (the
“Warrant Register”), in the name of the record Holder hereof from time to time. The Company may deem and treat the
registered Holder of this Warrant as the absolute owner hereof for the purpose of any exercise hereof or any distribution to the Holder,
and for all other purposes, absent actual notice to the contrary.
d)
Representation by the Holder. The Holder, by the acceptance hereof, represents and warrants that it is acquiring this Warrant
and, upon any exercise hereof, will acquire the Warrant Shares issuable upon such exercise, for its own account and not with a view to
or for distributing or reselling such Warrant Shares or any part thereof in violation of the Securities Act or any applicable state securities
law, except pursuant to sales registered or exempted under the Securities Act.
Section
5. Registration Rights.
5.1. Demand Registration.
5.1.1
Grant of Right. The Company, upon written demand (a “Demand Notice”) of the Holder(s) of at least 51% of the
Warrants and/or the underlying Warrant Shares (“Majority Holders”), agrees to register, on one occasion, all or any
portion of the Warrant Shares underlying the Warrants (collectively, the “Registrable Securities”). On such occasion, the
Company will file a registration statement with the Commission covering the Registrable Securities within thirty (30) days after receipt
of a Demand Notice and use its reasonable best efforts to have the registration statement declared effective promptly thereafter, subject
to compliance with review by the Commission; provided, however, that the Company shall not be required to comply with a Demand Notice
if the Company has filed a registration statement with respect to which the Holder is entitled to piggyback registration rights pursuant
to Section 5.2 hereof and either: (i) the Holder has elected to participate in the offering covered by such registration statement or
(ii) if such registration statement relates to an underwritten primary offering of securities of the Company, until the offering covered
by such registration statement has been withdrawn or until thirty (30) days after such offering is consummated. The demand for registration
may be made at any time beginning on the Initial Exercise Date and expiring on the fifth anniversary of the Effective Date. The Company
covenants and agrees to give written notice of its receipt of any Demand Notice by any Holder(s) to all other registered Holders of the
Warrants and/or the Registrable Securities within ten (10) days after the date of the receipt of any such Demand Notice.
5.1.2
Terms. The Company shall bear all fees and expenses attendant to the registration of the Registrable Securities pursuant to Section
5.1.1, but the Holders shall pay any and all underwriting commissions and the expenses of any legal counsel selected by the Holders to
represent them in connection with the sale of the Registrable Securities. The Company agrees to use its reasonable best efforts to cause
the filing required herein to become effective promptly and to qualify or register the Registrable Securities in such States as are reasonably
requested by the Holder(s); provided, however, that in no event shall the Company be required to register the Registrable Securities
in a State in which such registration would cause: (i) the Company to be obligated to register or license to do business in such State
or submit to general service of process in such State, or (ii) the principal shareholders of the Company to be obligated to escrow their
shares of capital stock of the Company. The Company shall cause any registration statement filed pursuant to the demand right granted
under Section 5.1.1 to remain effective for a period of at least twelve (12) consecutive months after the date that the Holders of the
Registrable Securities covered by such registration statement are first given the opportunity to sell all of such securities. The Holders
shall only use the prospectuses provided by the Company to sell the Warrant Shares covered by such registration statement, and will immediately
cease to use any prospectus furnished by the Company if the Company advises the Holder that such prospectus may no longer be used due
to a material misstatement or omission. Notwithstanding the provisions of this Section 5.1.2, the Holder shall be entitled to a demand
registration under this Section 5.1.2 on only one (1) occasion and such demand registration right shall terminate on the fifth anniversary
of the date of the Placement Agency Agreement (as defined below) in accordance with FINRA Rules 5110(g)(8)(B) and 5110(g)(8)(C).
5.2. “Piggy-Back” Registration.
5.2.1
Grant of Right. In addition to the demand right of registration described in Section 5.1 hereof, the Holder shall have the right,
for a period of no more than two (2) years from the Initial Exercise Date in accordance with FINRA Rule 5110(g)(8)(D), to include the
Registrable Securities as part of any other registration of securities filed by the Company (other than in connection with a transaction
contemplated by Rule 145(a) promulgated under the Securities Act or pursuant to Form S-8 or any equivalent form); provided, however,
that if, solely in connection with any primary underwritten public offering for the account of the Company, the managing underwriter(s)
thereof shall, in its reasonable discretion, impose a limitation on the number of Shares which may be included in the Registration Statement
because, in such underwriter(s)’ judgment, marketing or other factors dictate such limitation is necessary to facilitate public
distribution, then the Company shall be obligated to include in such Registration Statement only such limited portion of the Registrable
Securities with respect to which the Holder requested inclusion hereunder as the underwriter shall reasonably permit. Any exclusion of
Registrable Securities shall be made pro rata among the Holders seeking to include Registrable Securities in proportion to the number
of Registrable Securities sought to be included by such Holders; provided, however, that the Company shall not exclude any Registrable
Securities unless the Company has first excluded all outstanding securities, the holders of which are not entitled to inclusion of such
securities in such Registration Statement or are not entitled to pro rata inclusion with the Registrable Securities.
5.2.2
Terms. The Company shall bear all fees and expenses attendant to registering the Registrable Securities pursuant to Section 5.2.1
hereof, but the Holders shall pay any and all underwriting commissions and the expenses of any legal counsel selected by the Holders
to represent them in connection with the sale of the Registrable Securities. In the event of such a proposed registration, the Company
shall furnish the then Holders of outstanding Registrable Securities with not less than thirty (30) days written notice prior to the
proposed date of filing of such registration statement. Such notice to the Holders shall continue to be given for each registration statement
filed by the Company during the two (2) year period following the Initial Exercise Date until such time as all of the Registrable Securities
have been sold by the Holder. The holders of the Registrable Securities shall exercise the “piggy-back” rights provided for
herein by giving written notice within ten (10) days of the receipt of the Company’s notice of its intention to file a registration
statement. Except as otherwise provided in this Warrant, there shall be no limit on the number of times the Holder may request registration
under this Section 5.2.2; provided, however, that such registration rights shall terminate on the second anniversary of the Initial Exercise
Date.
5.3.
General Terms
5.3.1
Indemnification. The Company shall indemnify the Holder(s) of the Registrable Securities to be sold pursuant to any registration
statement hereunder and each person, if any, who controls such Holders within the meaning of Section 15 of the Securities Act or Section
20 (a) of the Exchange Act against all loss, claim, damage, expense or liability (including all reasonable attorneys’ fees and
other expenses reasonably incurred in investigating, preparing or defending against any claim whatsoever) to which any of them may become
subject under the Securities Act, the Exchange Act or otherwise, arising from such registration statement but only to the same extent
and with the same effect as the provisions pursuant to which the Company has agreed to indemnify the Placement Agent contained in Section
5.1 of the Placement Agency Agreement between the Placement Agent and the Company, dated as of May 31, 2026. The Holder(s) of the Registrable
Securities to be sold pursuant to such registration statement, and their successors and assigns, shall severally, and not jointly, indemnify
the Company, against all loss, claim, damage, expense or liability (including all reasonable attorneys’ fees and other expenses
reasonably incurred in investigating, preparing or defending against any claim whatsoever) to which they may become subject under the
Securities Act, the Exchange Act or otherwise, arising from information furnished by or on behalf of such Holders, or their successors
or assigns, in writing, for specific inclusion in such registration statement to the same extent and with the same effect as the provisions,
if any, contained in the Placement Agency Agreement pursuant to which the Placement Agent has agreed to indemnify the Company.
5.3.2
Exercise of Warrants. Nothing contained in this Warrant shall be construed as requiring the Holder(s) to exercise their Warrants
prior to or after the initial filing of any registration statement or the effectiveness thereof.
5.3.3
Documents Delivered to Holders. The Company shall furnish to each Holder participating in any of the foregoing offerings and to
each underwriter of any such offering, if any, a signed counterpart, addressed to such Holder or underwriter, of: (i) an opinion of counsel
to the Company, dated the effective date of such registration statement (and, if such registration includes an underwritten public offering,
an opinion dated the date of the closing under any underwriting agreement related thereto), and (ii) a “cold comfort” letter
dated the effective date of such registration statement (and, if such registration includes an underwritten public offering, a letter
dated the date of the closing under the underwriting agreement) signed by the independent registered public accounting firm which has
issued a report on the Company’s financial statements included in such registration statement, in each case covering substantially
the same matters with respect to such registration statement (and the prospectus included therein) and, in the case of such accountants’
letter, with respect to events subsequent to the date of such financial statements, as are customarily covered in opinions of issuer’s
counsel and in accountants’ letters delivered to underwriters in underwritten public offerings of securities. The Company shall
also deliver promptly to each Holder participating in the offering requesting the correspondence and memoranda described below and to
the managing underwriter, if any, copies of all correspondence between the Commission and the Company, its counsel or auditors and all
memoranda relating to discussions with the Commission or its staff with respect to the registration statement and permit each Holder
and underwriter to do such investigation, upon reasonable advance notice, with respect to information contained in or omitted from the
registration statement as it deems reasonably necessary to comply with applicable securities laws or rules of FINRA. Such investigation
shall include access to books, records and properties and opportunities to discuss the business of the Company with its officers and
independent auditors, all to such reasonable extent and at such reasonable times as any such Holder shall reasonably request.
5.3.4
Placement Agency Agreement. The Company shall enter into an underwriting agreement with the managing underwriter(s), if any, selected
by any Holders whose Registrable Securities are being registered pursuant to this Section 5, which managing underwriter shall be reasonably
satisfactory to the Company. Such agreement shall be reasonably satisfactory in form and substance to the Company, each Holder and such
managing underwriters, and shall contain such representations, warranties and covenants by the Company and such other terms as are customarily
contained in agreements of that type used by the managing underwriter. The Holders shall be parties to any underwriting agreement relating
to an underwritten sale of their Registrable Securities and may, at their option, require that any or all the representations, warranties
and covenants of the Company to or for the benefit of such underwriters shall also be made to and for the benefit of such Holders. Such
Holders shall not be required to make any representations or warranties to or agreements with the Company or the underwriters except
as they may relate to such Holders, their Warrant Shares and their intended methods of distribution.
5.3.5
Documents to be Delivered by Holder(s). Each of the Holder(s) participating in any of the foregoing offerings shall furnish to
the Company a completed and executed questionnaire provided by the Company requesting information customarily sought of selling security
holders.
5.3.6
Damages. Should the registration or the effectiveness thereof required by Sections 5.1 and 5.2 hereof be delayed by the Company
or the Company otherwise fails to comply with such provisions, the Holder(s) shall, in addition to any other legal or other relief available
to the Holder(s), be entitled to obtain specific performance or other equitable (including injunctive) relief against the threatened
breach of such provisions or the continuation of any such breach, without the necessity of proving actual damages and without the necessity
of posting bond or other security.
Section
6. Miscellaneous.
a) No
Rights as Shareholder Until Exercise. This Warrant does not entitle the Holder to any
voting rights, dividends or other rights as a shareholder of the Company prior to the exercise
hereof as set forth in Section 2(d)(i).
b) Loss,
Theft, Destruction or Mutilation of Warrant. The Company covenants that upon receipt
by the Company of evidence reasonably satisfactory to it of the loss, theft, destruction
or mutilation of this Warrant or any certificate relating to the Warrant Shares, and in case
of loss, theft or destruction, of indemnity or security reasonably satisfactory to it (which,
in the case of the Warrant, shall not include the posting of any bond), and upon surrender
and cancellation of such Warrant or stock certificate, if mutilated, the Company will make
and deliver a new Warrant or stock certificate of like tenor and dated as of such cancellation,
in lieu of such Warrant or stock certificate.
c) Saturdays,
Sundays, Holidays, etc. If the last or appointed day for the taking of any action or
the expiration of any right required or granted herein shall not be a Trading Day, then,
such action may be taken or such right may be exercised on the next succeeding Trading Day.
d) Authorized
Shares.
The
Company covenants that, during the period the Warrant is outstanding, it will reserve from its authorized and unissued Common Shares
a sufficient number of shares to provide for the issuance of the Warrant Shares upon the exercise of any purchase rights under this Warrant.
The Company further covenants that its issuance of this Warrant shall constitute full authority to its officers who are charged with
the duty of issuing the necessary Warrant Shares upon the exercise of the purchase rights under this Warrant. The Company will take all
such reasonable action as may be necessary to assure that such Warrant Shares may be issued as provided herein without violation of any
applicable law or regulation, or of any requirements of the Trading Market upon which the Common Shares may be listed. The Company covenants
that all Warrant Shares which may be issued upon the exercise of the purchase rights represented by this Warrant will, upon exercise
of the purchase rights represented by this Warrant and payment for such Warrant Shares in accordance herewith, be duly authorized, validly
issued, fully paid and nonassessable and free from all taxes, liens and charges created by the Company in respect of the issue thereof
(other than taxes in respect of any transfer occurring contemporaneously with such issue).
Except
and to the extent as waived or consented to by the Holder, the Company shall not by any action, including, without limitation, amending
its notice of articles or articles or through any reorganization, transfer of assets, consolidation, merger, amalgamation, arrangement,
dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of
the terms of this Warrant, but will at all times in good faith assist in the carrying out of all such terms and in the taking of all
such actions as may be necessary or appropriate to protect the rights of Holder as set forth in this Warrant against impairment. Without
limiting the generality of the foregoing, the Company will (i) not increase the par value of any Warrant Shares above the amount payable
therefor upon such exercise immediately prior to such increase in par value, (ii) take all such action as may be necessary or appropriate
in order that the Company may validly and legally issue fully paid and nonassessable Warrant Shares upon the exercise of this Warrant
and (iii) use commercially reasonable efforts to obtain all such authorizations, exemptions or consents from any public regulatory body
having jurisdiction thereof, as may be, necessary to enable the Company to perform its obligations under this Warrant.
Before
taking any action which would result in an adjustment in the number of Warrant Shares for which this Warrant is exercisable or in the
Exercise Price, the Company shall obtain all such authorizations or exemptions thereof, or consents thereto, as may be necessary from
any public regulatory body or bodies having jurisdiction thereof.
e) Jurisdiction.
All questions concerning the construction, validity, enforcement and interpretation of this
Warrant shall be determined in accordance with the provisions of the placement agency agreement,
dated May 31, 2026, by and between the Company and ThinkEquity LLC (the “Placement
Agency Agreement”).
f) Restrictions.
The Holder acknowledges that the Warrant Shares acquired upon the exercise of this Warrant,
if not registered, or otherwise able to be resold or transferred without restriction pursuant
to an exemption from registration under the Securities Act, and the Holder does not utilize
cashless exercise, will have restrictions upon resale imposed by state and federal securities
laws.
g) Nonwaiver
and Expenses. No course of dealing or any delay or failure to exercise any right hereunder
on the part of Holder shall operate as a waiver of such right or otherwise prejudice the
Holder’s rights, powers or remedies. Without limiting any other provision of this Warrant
or the Placement Agency Agreement, if the Company willfully and knowingly fails to comply
with any provision of this Warrant, which results in any material damages to the Holder,
the Company shall pay to the Holder such amounts as shall be sufficient to cover any costs
and expenses including, but not limited to, reasonable attorneys’ fees, including those
of appellate proceedings, incurred by the Holder in collecting any amounts due pursuant hereto
or in otherwise enforcing any of its rights, powers or remedies hereunder.
h) Notices.
Any notice, request or other document required or permitted to be given or delivered to the
Holder by the Company shall be delivered in accordance with the notice provisions of the
Placement Agency Agreement.
i) Limitation
of Liability. No provision hereof, in the absence of any affirmative action by the Holder
to exercise this Warrant to purchase Warrant Shares, and no enumeration herein of the rights
or privileges of the Holder, shall give rise to any liability of the Holder for the purchase
price of any Common Shares or as a shareholder of the Company, whether such liability is
asserted by the Company or by creditors of the Company.
j) Remedies.
The Holder, in addition to being entitled to exercise all rights granted by law, including
recovery of damages, will be entitled to specific performance of its rights under this Warrant.
The Company agrees that monetary damages would not be adequate compensation for any loss
incurred by reason of a breach by it of the provisions of this Warrant and hereby agrees
to waive and not to assert the defense in any action for specific performance that a remedy
at law would be adequate.
k) Successors
and Assigns. Subject to applicable securities laws, this Warrant and the rights and obligations
evidenced hereby shall inure to the benefit of and be binding upon the successors and permitted
assigns of the Company and the successors and permitted assigns of Holder. The provisions
of this Warrant are intended to be for the benefit of any Holder from time to time of this
Warrant and shall be enforceable by the Holder or holder of Warrant Shares.
l) Amendment.
This Warrant may be modified or amended or the provisions hereof waived with the written
consent of the Company and the Holder.
m) Severability.
Wherever possible, each provision of this Warrant shall be interpreted in such manner as
to be effective and valid under applicable law, but if any provision of this Warrant shall
be prohibited by or invalid under applicable law, such provision shall be ineffective to
the extent of such prohibition or invalidity, without invalidating the remainder of such
provisions or the remaining provisions of this Warrant.
n) Headings.
The headings used in this Warrant are for the convenience of reference only and shall not,
for any purpose, be deemed a part of this Warrant.
********************
(Signature
Page Follows)
IN
WITNESS WHEREOF, the Company has caused this Warrant to be executed by its officer thereunto duly authorized as of the date first above
indicated.
BRIACELL
THERAPEUTICS CORP.
By:
Name:
Title:
NOTICE
OF EXERCISE
TO:
briacell
therapeutics corp.
(1)
The undersigned hereby elects to purchase ________ Warrant Shares of the Company pursuant to the terms of the attached Warrant (only
if exercised in full), and tenders herewith payment of the exercise price in full, together with all applicable transfer taxes, if any.
(2)
Payment shall take the form of (check applicable box):
[ ]
in lawful money of the United States; or
[ ]
if permitted the cancellation of such number of Warrant Shares as is necessary, in accordance with the formula set forth in subsection
2(c), to exercise this Warrant with respect to the maximum number of Warrant Shares purchasable pursuant to the cashless exercise procedure
set forth in subsection 2(c).
(3)
Please register and issue said Warrant Shares in the name of the undersigned or in such other name as is specified below:
_______________________________
The
Warrant Shares shall be delivered to the following DWAC Account Number or by physical delivery of a certificate to:
_______________________________
_______________________________
_______________________________
(4)
Accredited Investor. If the Warrant is being exercised via cash exercise, the undersigned is an “accredited investor”
as defined in Regulation D promulgated under the Securities Act of 1933, as amended
[SIGNATURE
OF HOLDER]
Name
of Investing Entity: _______________________________________________________________
Signature
of Authorized Signatory of Investing Entity: _________________________________________
Name
of Authorized Signatory: ___________________________________________________________
Title
of Authorized Signatory: ____________________________________________________________
Date:
________________________________________________________________________________
ASSIGNMENT
FORM
(To
assign the foregoing warrant, execute
this form and supply required information.
Do not use this form to exercise the warrant.)
FOR
VALUE RECEIVED, [____] all of or [_______] shares of the foregoing Warrant and all rights evidenced thereby are hereby assigned to
_______________________________________________
whose address is
_______________________________________________________________.
_______________________________________________________________
Dated:
______________, _______
Holder’s Signature:
Holder’s Address:
NOTE:
The signature to this Assignment Form must correspond with the name as it appears on the face of the Warrant, without alteration or enlargement
or any change whatsoever. Officers of corporations and those acting in a fiduciary or other representative capacity should file proper
evidence of authority to assign the foregoing Warrant.
EX-5.1
EX-5.1
Filename: ex5-1.htm · Sequence: 3
Exhibit
5.1
June
2, 2026
BriaCell
Therapeutics Corp.
235
15th Street, Suite 300
West
Vancouver, BC, V7T 2X1
Re:
BriaCell
Therapeutics Corp. -
Best
Efforts Offering of Common Shares
We
have acted as Canadian counsel to BriaCell Therapeutics Corp., a corporation organized under the laws of the Province of British Columbia
(the “Company”), in connection with the sale of 1,449,300 common shares (the “Common Shares”) in
the capital of the Company (the “Offering”).
We
understand that the Offering was made in the United States pursuant to the prospectus supplement, dated May 31, 2026 (the “Prospectus”),
to the prospectus included as part of a registration statement (the “Registration Statement”) on Form S-3 (No. 333-276650),
filed on January 22, 2024 by the Company and declared effective on January 31, 2024 by the Securities and Exchange Commission under the
Securities Act of 1933, as amended (the “Securities Act”). The Common Shares were sold and issued in accordance
with the terms of a placement agency agreement dated June 2, 2026 (the “Agency Agreement”) between ThinkEquity
LLC (the “Placement Agent”) and the Company.
We
are solicitors qualified to practice law in the provinces of Ontario, Alberta, and British Columbia and we express no opinion as to the
laws of any jurisdiction, or as to any matters governed by the laws of any jurisdiction, other than the laws of the provinces of Ontario,
Alberta, and British Columbia and the laws of Canada applicable therein. Notwithstanding the foregoing and our opinions set forth below,
we express no opinion with respect to the compliance or non-compliance with applicable privacy laws in connection with the issuance and
sale of the Common Shares.
As
counsel for the Company, we have examined originals or copies, certified or otherwise identified to our satisfaction, of such documents,
corporate records, certificates of public officials and other instruments as we have deemed necessary for the purposes of rendering this
opinion and we are familiar with the proceedings taken and proposed to be taken by the Corporation in connection with the authorization,
issuance and sale of the Common Shares. In our examination, we have assumed the genuineness of all signatures; the legal capacity of
all signatories; the authenticity of all documents submitted to us as originals and the conformity with the originals of all documents
submitted to us as copies; and the truthfulness and accuracy of the corporate records of the Company and of all certificates of public
officials and officers of the Company, not being aware of any reason why the addressees of this opinion would not be entitled to rely
on any of the certificates upon which we are relying in rendering this opinion.
Our
opinion is expressed with respect to the laws of the provinces of Ontario, Alberta, and British Columbia in effect on the date of this
opinion. We have no responsibility or obligation to: (i) update this opinion; (ii) take into account or inform the addressees or any
other person of any changes in law, facts or other developments subsequent to this date that do or may affect the opinion we express;
or (iii) advise the addressee or any other person of any other change in any matter addressed in this opinion. Nor do we have any responsibility
or obligation to consider the applicability or correctness of this opinion to any person other than the addressee.
June
2, 2026
Page
2
Where
our opinion expressed herein refers to Common Shares having been issued as being “fully-paid and non-assessable”, such opinion
assumes that all required consideration (in whatever form) has been paid or provided. No opinion is expressed as to the adequacy of any
consideration received.
Based
upon the foregoing, and subject to the foregoing qualifications, assumptions, and limitations and the further limitations set forth below,
we are of the opinion that:
1.
The
Common Shares have been duly authorized for issuance and, when issued and paid for in accordance with the terms set forth in the
Agency Agreement, will be validly issued, fully paid and non-assessable common shares in the capital of the Company.
This
opinion relates exclusively to the transaction outlined above and is for the sole use and benefit of the persons to whom it is addressed.
Accordingly, this opinion or any copy hereof, may not be delivered to, or relied upon, by any other person or used in connection with
any other transaction without our prior written consent. This opinion is limited to the matters stated herein, and no opinion or belief
is implied or may be inferred beyond the matters expressly stated herein.
We
consent to the use of this opinion as an exhibit to the Current Report on Form 8-K to be filed by the Company with the SEC on June 2,
2026, and its incorporation by reference in the Registration Statement. We also hereby consent to the reference to our firm under the
caption “Legal Matters” in the Prospectus Supplement. In giving this consent, we do not admit that we are in the category
of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the SEC thereunder.
Yours
truly,
/s/
Bennett Jones LLP
Bennett
Jones LLP
EX-10.1
EX-10.1
Filename: ex10-1.htm · Sequence: 4
Exhibit 10.1
PLACEMENT
AGENCY AGREEMENT
between
BRIACELL
THERAPEUTICS CORP.
and
THINKEQUITY
LLC
BRIACELL
THERAPEUTICS CORP.
PLACEMENT
AGENCY AGREEMENT
New
York, New York
May 31, 2026
ThinkEquity
LLC
17
State Street, 41st Fl
New
York, NY 10004
Ladies
and Gentlemen:
This
Placement Agency Agreement (the “Agreement”) sets forth the terms upon which ThinkEquity LLC
(“ThinkEquity” or the “Placement Agent”) shall be engaged by BriaCell Therapeutics Corp., a
corporation formed under the laws of the Province of British Columbia (collectively with its subsidiaries and affiliates, including,
without limitation, all entities disclosed or described in the Registration Statement (as hereinafter defined) as being subsidiaries
or affiliates of BriaCell Therapeutics Corp., the “Company”), to act as the exclusive placement agent in
connection with the offering (hereinafter referred to as the “Offering”) of up to 1,449,300 common shares (the
“Shares”) of the Company, with no par value per common share (the “Common Shares”) and nil
pre-funded warrants (each a “Pre-Funded Warrant,” and in the aggregate, the “Pre-Funded
Warrants,” the Common Shares underlying the Pre-Funded Warrants, the “Warrant Shares,” and the Shares,
Pre-Funded Warrants, and Warrant Shares, the “Securities”), each to purchase one Common Share at an exercise
price of US$0.001 until such time as the Pre-Funded Warrant is exercised in full, subject to adjustment as provided in the
certificate (the “Pre-Funded Warrant Certificate”) evidencing the Pre-Funded Warrants, the form of which is
attached hereto as Exhibit D, directly to various investors (each, an “Investor” and, collectively, the
“Investors”). The purchase price to the Investors for each Share is US$3.25 (the “Share Offering
Price”), and the purchase price to the Investors for each Pre-Funded Warrant is US$3.249. The Placement Agent may retain
other brokers or dealers to act as sub-agents or selected-dealers on its behalf in connection with the Offering.
1. Agreement
to Act as Placement Agent; Closing; Placement Agent Compensation.
1.1 On
the basis of the representations, warranties and agreements of the Company herein contained, and subject to all the terms and conditions
of this Agreement between the Company and the Placement Agent, the Placement Agent is appointed as the Company’s exclusive placement
agent subject to the terms and conditions contained herein. On the basis of such representations and warranties and subject to such terms
and conditions, the Placement Agent hereby accepts such appointment and agrees to perform the services hereunder diligently and in good
faith and in a professional and businesslike manner and to use its commercially reasonable efforts to assist the Company in finding subscribers
of the Securities and to complete the Offering. The Placement Agent has no obligation to purchase any of the Securities. Unless sooner
terminated in accordance with this Agreement, the engagement of the Placement Agent hereunder shall continue until the later of the Termination
Date or the Closing. The Offering will be made on a “reasonable best efforts” basis. The Placement Agent may retain other
brokers or dealers to act as sub- placement agents on its behalf in connection with the Offering, with any fees they may be entitled
to being paid out of the fee paid to the Placement Agent pursuant to Section 1.5.
1.2 Payment
of the aggregate purchase price paid by any and all Investors less the Cash Fee, and the other accountable expenses payable in accordance
with Section 3.10 of this Agreement (the “Purchase Price”) for, and delivery of, the Securities (the “Closing”)
shall be made at the offices of Cozen O’Connor LLP (“Placement Agent Counsel”), Bentall 5, 550 Burrard Street,
Suite 2501, Vancouver, British Columbia, V6C 2B5, Canada, or at such other place as shall be agreed upon by the Placement Agent and the
Company, at 10:00 a.m. (New York City time) on June 2, 2026 (such time and date of payment and delivery being herein called “Closing
Date”). The term “Business Day” means any day other than a Saturday, a Sunday or a legal holiday or a day on which
banking institutions are authorized or obligated by law to close in New York, New York.
2
1.3 On
the Closing Date, (i) the Purchase Price will be released to the Company either (a) by the Placement Agent on behalf of each Investor
for the Securities to be issued and sold to such Investor at the Closing, by wire transfer of immediately available funds in accordance
with the flow of funds letter regarding the Closing, or (b) by the Investor wiring the Purchase Price to the Company by wire transfer
to an account designated in writing by the Company, and (ii) the Company shall (A) cause its transfer agent (together with any subsequent
transfer agent, the “Transfer Agent”) through the Depository Trust Company (“DTC”) Fast Automated Securities
Transfer Program, to credit such aggregate number of Shares that each Investor is purchasing as set forth in the flow of funds letter
regarding the Closing to either (a) the Placement Agent’s balance account with DTC through its Deposit/Withdrawal at Custodian
system, or (b) directly to the account of each Investor or its respective nominee(s), at the designated account with DTC as provided
on the flow of funds letter (if applicable) and (ii) the Pre-Funded Warrants shall be delivered to each Investor or to the Placement
Agent on behalf of the Investor. All actions taken at the Closing shall be deemed to have occurred simultaneously on the Closing Date.
Any Securities for which payment has not been received by the Company, to the extent they have been delivered to the Placement Agent
or any such Investor, shall be returned to the Company.
1.4 No
Securities which the Company has agreed to sell pursuant to this Agreement shall be deemed to have been purchased and paid for, or issued
and sold by the Company, until the appropriate corresponding number of Securities shall have been delivered to the Investors or the Placement
Agent against payment therefor. If the Company shall default in its obligations to deliver the Securities to the Investors or the Placement
Agent on behalf of such Investors as per such instructions, the Company shall indemnify and hold the Placement Agent harmless against
any loss, claim, damage or liability directly or indirectly arising from or as a result of such default by the Company.
1.5 As
compensation for services rendered, on the Closing Date, the Company shall pay to the Placement Agent the following:
1.5.1. A
cash fee (the “Cash Fee”) equal to 7.5% of the aggregate purchase price paid by the Investors and 3.75% of the aggregate
purchase price paid by the purchasers set forth in Schedule 4 (the “Company Investors”) in respect of the Securities
purchased at the Closing, which fees shall be deducted from the Purchase Price payable at Closing.
1.5.2. [RESERVED].
1.5.3. A
warrant to the Placement Agent and/or its designees (“Placement Agent’s Warrant”) for the purchase of 72,465
Common Shares (the “Placement Agent’s Warrant Shares”), representing 5% of the Shares and Common Shares issuable
upon exercise of the Pre-Funded Warrants purchased at the Closing, for an aggregate purchase price of US$100.00. The Placement Agent’s
Warrant agreement, in the form attached hereto as Exhibit E (the “Placement Agent’s Warrant Agreement”),
shall be exercisable, in whole or in part, immediately following the Closing and expiring on the five-year anniversary of the date hereof,
at an initial exercise price per Common Share of US$4.0625, which is equal to 125% of the Share Offering Price. The Placement Agent’s
Warrant Agreement and the Common Shares issuable upon exercise thereof are hereinafter referred to together as the “Placement
Agent’s Securities”.
1.5.4. Delivery
of the Placement Agent’s Warrant Agreement shall be made on the Closing Date and shall be issued in the name or names and in such
authorized denominations as the Placement Agent may request.
3
1.6 The
Company hereby acknowledges that (i) the Offering, including the determination of the offering price of the Shares and any related discounts,
commissions and fees, shall be an arm’s-length commercial transaction between the Company and the Investors, (ii) the Placement
Agent will be acting as an independent contractor and will not be the agent or fiduciary of the Company or its shareholders, creditors,
employees, the Investors, the Other Investors or any other party, (iii) the Placement Agent shall not assume an advisory or fiduciary
responsibility in favor of the Company (irrespective of whether the Placement Agent has advised or is currently advising the Company
on other matters) and the Placement Agent shall not have any obligation to the Company with respect to the Offering, except as may be
set forth expressly herein, (iv) the Placement Agent and its Affiliates may be engaged in a broad range of transactions that involve
interests that differ from those of the Company and (v) the Placement Agent will not provide any legal, accounting, regulatory or tax
advice with respect to the Offering, and the Company shall consult its own legal, accounting, regulatory and tax advisors to the extent
it deems appropriate.
1.7 The
Company is and will be solely responsible for the contents of any and all written or oral communications provided to the Investors regarding
the Offering or the Securities; and the Company recognizes that the Placement Agent, in acting pursuant to this Agreement, will
be using information provided by the Company and its agents and the Placement Agent assumes no responsibility for, and may rely, without
independent verification, on the accuracy and completeness of any such information.
1.8 The
Company agrees that any information or advice rendered by the Placement Agent in connection with this engagement is for the confidential
use of the Board of Directors of the Company (the “Board”) only and the Company will not, and will not permit any
third party to, disclose or otherwise refer to such advice or information, in any manner without the Placement Agent’s prior written
consent.
2. Representations
and Warranties of the Company. The Company represents and warrants to the Placement Agent as of the Applicable Time (as defined below),
as of the Closing Date, as follows:
2.1 Filing
of Registration Statement.
2.1.1. Pursuant
to the Securities Act. The Company has filed with the U.S. Securities and Exchange Commission (the “Commission”)
a “shelf” registration statement on Form S-3 (File No. 333- 276650), including any related prospectus or prospectuses, for
the registration of the Securities under the Securities Act of 1933, as amended (the “Securities Act”), which registration
statement was prepared by the Company in all material respects in conformity with the requirements of the Securities Act and the rules
and regulations of the Commission under the Securities Act (the “Securities Act Regulations”) and contains and will
contain all material statements that are required to be stated therein in accordance with the Securities Act and the Securities Act Regulations.
Except as the context may otherwise require, such registration statement on file with the Commission at any given time, including any
amendments thereto to such time, exhibits and schedules thereto at such time, documents filed as a part thereof or incorporated pursuant
to Item 12 of Form S-3 under the Securities Act at such time and the documents and information otherwise deemed to be a part thereof
or included therein pursuant to Rule 430B of the Securities Act Regulations (the “Rule 430B Information”) or otherwise
pursuant to the Securities Act Regulations at such time, is referred to herein as the “Registration Statement.” The
Registration Statement at the time it originally became effective is referred to herein as the “Initial Registration Statement.”
If the Company files any registration statement pursuant to Rule 462(b) of the Securities Act Regulations, then after such filing, the
term “Registration Statement” shall include such registration statement filed pursuant to Rule 462(b). The Registration Statement
was declared effective by the Commission on January 31, 2024.
The
prospectus in the form in which it was filed with the Commission in connection with the Initial Registration Statement is herein called
the “Base Prospectus”. Each preliminary prospectus supplement to the Base Prospectus (including the Base Prospectus
as so supplemented) that described the Securities and the Offering and omitted the Rule 430B Information and that was used prior to the
filing of the final prospectus supplement referred to in the following paragraph is herein called the “Preliminary Prospectus”.
4
Promptly
after the execution and delivery of this Agreement, the Company will prepare and file with the Commission a final prospectus supplement
to the Base Prospectus relating to the Securities and the Offering in accordance with the provisions of Rule 430B and Rule 424(b) of
the Securities Act Regulations. Such final prospectus supplement (including the Base Prospectus as so supplemented), in the form filed
with the Commission pursuant to Rule 424(b) under the Securities Act is herein called the “Prospectus.” Any reference
herein to the Base Prospectus, any Preliminary Prospectus, and the Prospectus shall be deemed to refer to and include the documents incorporated
by reference therein pursuant to Item 12 of Form S-3 under the Securities Act as of the date of such prospectus.
“Applicable
Time” means 6:21 p.m., Eastern time, on the date of this Agreement.
“Canadian
Public Disclosure Documents” means all information filed by or on behalf of the Company since February 23, 2021 with the Canadian
Securities Regulators of the Provinces of British Columbia, Alberta, Manitoba, New Brunswick, Newfoundland and Labrador, Nova Scotia,
Ontario, Prince Edward Island, Québec, Saskatchewan, and the Territories of the Yukon, Northwest Territories and Nunavut, and
available for public viewing on SEDAR+.
“Canadian
Securities Laws” means collectively, all applicable securities laws in Canada and the respective rules and regulations made
thereunder, together with applicable multilateral or national instruments, orders, rulings, policies, rules and other regulatory instruments
issued or adopted (and published) by Canadian Securities Regulators.
“Canadian
Securities Regulators” means, collectively, the securities regulators or other securities regulatory authorities in Canada;
“Disclosure
Package” means any Issuer General Use Free Writing Prospectus issued at or prior to the Applicable Time, the Preliminary Prospectus
if any, together with the pricing terms and other final terms of the Offering provided to Investors as set forth on Schedule 1
hereto, all considered together.
“Issuer
Free Writing Prospectus” means any “issuer free writing prospectus,” as defined in Rule 433 of the Securities Act
Regulations (“Rule 433”), including without limitation any “free writing prospectus” (as defined in Rule
405 of the Securities Act Regulations) relating to the Securities that is (i) required to be filed with the Commission by the Company,
(ii) a “road show that is a written communication” within the meaning of Rule 433(d)(8)(i), whether or not required to be
filed with the Commission, or (iii) exempt from filing with the Commission pursuant to Rule 433(d)(5)(i) because it contains a description
of the Securities or of the Offering that does not reflect the final terms, in each case in the form filed or required to be filed with
the Commission or, if not required to be filed, in the form retained in the Company’s records pursuant to Rule 433(g).
“Issuer
General Use Free Writing Prospectus” means any Issuer Free Writing Prospectus that is intended for general distribution to
prospective investors (other than a “bona fide electronic road show,” as defined in Rule 433 (the “Bona Fide
Electronic Roadshow”)), as evidenced by its being specified in Schedule 2-A hereto.
“Issuer
Limited Use Free Writing Prospectus” means any Issuer Free Writing Prospectus that is not an Issuer General Use Free Writing
Prospectus.
5
2.1.1. Registration
Pursuant to Section 12(b) of the Exchange Act. The Company has filed with the Commission registration statements on Form 8-A (File
Number 001-40101) providing for the registration pursuant to Section 12(b) under the Securities Exchange Act of 1934, as amended (the
“Exchange Act”), of the Common Shares and certain warrants to purchase Common Shares (the “Public Warrants”).
The registration of the Common Shares and the Public Warrants under the Exchange Act became effective prior to the date hereof. The Company
has taken no action designed to, or likely to have the effect of, terminating the registration of the Common Shares or Public Warrants
under the Exchange Act, nor has the Company received any notification that the Commission is contemplating terminating such registration.
2.1.2. [RESERVED].
2.2 Stock
Exchange Listing. The Company’s Common Shares and Public Warrants are listed on the Nasdaq Capital Market (the “Exchange”)
under the symbols “BCTX”, “BCTXL”, and “BCTXZ”, respectively. The Company’s Common Shares are
also listed on the Toronto Stock Exchange (the “TSX”) under the symbol “BCT”. The Common Shares issuable
pursuant to the Offering and the Placement Agent’s Warrant Shares have been conditionally approved for listing on the TSX, and
the Company has taken no action designed to, or likely to have the effect of, delisting either the Common Shares or the Public Warrants
from the Exchange or the TSX, as applicable, nor has the Company received any notification that the Exchange or the TSX is contemplating
terminating such listing or that the Company is out of compliance with the listing or maintenance requirements of the Exchange or the
TSX, except as described in the Registration Statement, the Disclosure Package and the Prospectus.
2.3 No
Stop Orders, etc. Neither the Commission nor, to the Company’s knowledge, any state regulatory authority has issued any order
preventing or suspending the use of the Registration Statement, any Preliminary Prospectus or the Prospectus or has instituted or, to
the Company’s knowledge, threatened to institute, any proceedings with respect to such an order. None of the Canadian Securities
Regulators has issued an order ceasing or suspending trading in any securities of the Company, or ceasing or suspending trading by the
directors, officers or shareholders of the Company, or any of them, or prohibiting the trade or distribution of any of the securities
referred to herein (the “Cease Trade Order”) or has instituted or, to the Company’s knowledge, threatened to institute,
any proceedings with respect to such an order. The Company has complied with each request (if any) from the Commission for additional
information.
2.4 Disclosures
in Registration Statement.
2.4.1. Compliance
with Securities Act and 10b-5 Representation.
(i) Each
of the Registration Statement and any post-effective amendment thereto, at the time it became effective (including each deemed effective
date with respect to the Placement Agent pursuant to Rule 430B or otherwise under the Securities Act) complied and will comply in all
material respects with the requirements of the Securities Act and the Securities Act Regulations. The conditions for use of Form S-3,
set forth in the General Instructions thereto, including, but not limited to, General Instruction I.B.1 and other conditions related
to the offer and sale of the Securities, have been satisfied. The Prospectus, at the time each was or will be filed with the Commission,
complied and will comply in all material respects with the requirements of the Securities Act and the Securities Act Regulations. Each
Preliminary Prospectus and the Prospectus, at the time each was or will be filed with the Commission, complied and will comply in all
material respects with the requirements of the Securities Act and the Securities Act Regulations. Each Preliminary Prospectus delivered
to the Placement Agent for use in connection with this Offering and the Prospectus was or will be identical to the electronically transmitted
copies thereof filed with the Commission pursuant to EDGAR, except to the extent permitted by Regulation S-T promulgated under the Securities
Act.
(ii) Neither
the Registration Statement nor any amendment thereto, at its effective time, as of the Applicable Time, at the Closing Date contained,
contains, or will contain an untrue statement of a material fact or omitted, omits, or will omit to state a material fact required to
be stated therein or necessary to make the statements therein not misleading.
6
(iii) The
Disclosure Package, as of the Applicable Time, at the Closing Date, did not, does not and will not include an untrue statement of a material
fact or omit to state a material fact necessary in order to make the statements therein, in the light of the circumstances under which
they were made, not misleading; and each Issuer Limited Use Free Writing Prospectus hereto does not conflict with the information contained
in the Registration Statement, any Preliminary Prospectus, the Preliminary Prospectus or the Prospectus, and each such Issuer Limited
Use Free Writing Prospectus, as supplemented by and taken together with the Preliminary Prospectus as of the Applicable Time, did not
include an untrue statement of a material fact or omit to state a material fact necessary in order to make the statements therein, in
light of the circumstances under which they were made, not misleading; provided, however, that this representation and warranty shall
not apply to statements made or statements omitted in reliance upon and in conformity with written information furnished to the Company
with respect to the Placement Agent by the Placement Agent expressly for use in the Registration Statement, the Preliminary Prospectus
or the Prospectus or any amendment thereof or supplement thereto. The parties acknowledge and agree that such information provided by
or on behalf of the Placement Agent consists solely of the following disclosure contained in the “Plan of Distribution” section
of the Prospectus: “Regulation M Compliance” and “Other Relationships and Affiliations” (the “Placement
Agent’s Information”). Neither the Prospectus nor any amendment or supplement thereto (including any prospectus wrapper),
as of its issue date, at the time of any filing with the Commission pursuant to Rule 424(b), at the Closing Date, included, includes
or will include an untrue statement of a material fact or omitted, omits, or will omit to state a material fact necessary in order to
make the statements therein, in light of the circumstances under which they were made, not misleading;
(iv) Neither
the Prospectus nor any amendment or supplement thereto (including any prospectus wrapper), as of its issue date, at the time of any filing
with the Commission pursuant to Rule 424(b), at the Closing Date, included, includes or will include an untrue statement of a material
fact or omitted, omits, or will omit to state a material fact necessary in order to make the statements therein, in light of the circumstances
under which they were made, not misleading; provided, however, that this representation and warranty shall not apply to the Placement
Agent’s Information;
(v) The
documents incorporated by reference in the Registration Statement, the Disclosure Package, and the Prospectus, when they became effective
or were filed with the Commission, as the case may be, conformed in all material respects to the requirements of the Securities Act or
the Exchange Act, as applicable, and the rules and regulations of the Commission thereunder and none of such documents contained any
untrue statement of a material fact or omitted to state any material fact required to be stated therein or necessary to make the statements
therein, in light of the circumstances under which they were made, not misleading; and any further documents so filed and incorporated
by reference in the Registration Statement, the Disclosure Package, and the Prospectus, when such documents become effective or are filed
with the Commission, as the case may be, will conform in all material respects to the requirements of the Securities Act or the Exchange
Act, as applicable, and the rules and regulations of the Commission thereunder, and will not contain any untrue statement of a material
fact or omit to state any material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances
under which they were made, not misleading.
7
2.4.2. Disclosure
of Agreements. The agreements and documents described in the Registration Statement, the Disclosure Package, and the Prospectus conform
in all material respects to the descriptions thereof contained or incorporated by reference therein and there are no agreements or other
documents required by the Securities Act and the Securities Act Regulations to be described in the Registration Statement, the Disclosure
Package, and the Prospectus or to be filed with the Commission as exhibits to the Registration Statement or to be incorporated by reference
in the Registration Statement, the Disclosure Package or the Prospectus, that have not been so described or filed or incorporated by
reference. Each agreement or other instrument (however characterized or described) to which the Company is a party or by which it is
or may be bound or affected and (i) that is referred to or incorporated by reference in the Registration Statement, the Disclosure Package,
and the Prospectus, or (ii) is material to the Company’s business, has been duly authorized and validly executed by the Company,
is in full force and effect in all material respects and is enforceable against the Company and, to the Company’s knowledge, the
other parties thereto, in accordance with its terms, except (x) as such enforceability may be limited by bankruptcy, insolvency, reorganization,
or similar laws affecting creditors’ rights generally, (y) as enforceability of any indemnification or contribution provision may
be limited under the federal and state securities laws, and (z) that the remedy of specific performance and injunctive and other forms
of equitable relief may be subject to the equitable defenses and to the discretion of the court before which any proceeding therefor
may be brought. None of such agreements or instruments has been assigned by the Company, and neither the Company nor, to the Company’s
knowledge, any other party is in default thereunder and, to the Company’s knowledge, no event has occurred that, with the lapse
of time or the giving of notice, or both, would constitute a default thereunder. To the Company’s knowledge, performance by the
Company of the material provisions of such agreements or instruments will not result in a violation of any existing applicable law, rule,
regulation, ordinance, judgment, order, or decree of any governmental or regulatory agency, body, authority or court, domestic or foreign,
having jurisdiction over the Company or any of its assets or businesses (each, a “Governmental Entity”), including,
without limitation, those relating to environmental laws and regulations. Except as disclosed in the Registration Statement, the Disclosure
Package and the Prospectus, the Company has no subsidiaries and has no other interest, nominal or beneficial, direct or indirect, in
any other corporation, joint venture or other business entity.
2.4.3. Prior
Securities Transactions. No securities of the Company have been sold by the Company or by or on behalf of, or for the benefit of,
any person or persons controlling, controlled by, or under common control with the Company, except as disclosed or incorporated by reference
in the Registration Statement, the Disclosure Package, and the Preliminary Prospectus.
2.4.4. Regulations.
The disclosures in the Registration Statement, the Disclosure Package, and the Prospectus concerning the effects of federal, state, local,
and all foreign laws, rules and regulation relating to the Offering and the Company’s business as currently contemplated are accurate,
correct and complete in all material respects and no other such regulations are required to be disclosed in the Registration Statement,
the Disclosure Package, and the Prospectus which are not so disclosed.
2.4.5. No
Other Distribution of Offering Materials. The Company has not, directly or indirectly, distributed and will not distribute any offering
material in connection with the Offering other than any Preliminary Prospectus, the Disclosure Package, the Prospectus, and other materials,
if any, permitted under the Securities Act and consistent with Section 3.2 below.
2.5 Changes
After Dates in Registration Statement.
2.5.1. No
Material Adverse Change. Since the respective dates as of which information is given in the Registration Statement, the Disclosure
Package, and the Prospectus, except as otherwise specifically stated therein: (i) there has been no material adverse change in the financial
position or results of operations of the Company, nor any change or development that, singularly or in the aggregate, would involve a
material adverse change or a prospective material adverse change, in or affecting the general affairs, management, condition (financial
or otherwise), results of operations, shareholders’ equity, business, assets, properties or prospects of the Company (a “Material
Adverse Change”); (ii) there have been no material transactions entered into by the Company, other than as contemplated
pursuant to this Agreement; (iii) no officer or director of the Company has resigned from any position with the Company; and (iv) the
Company has not sustained any material loss or interference with its business or properties from fire, explosion, flood, earthquake,
hurricane, accident or other calamity. The Company does not have pending before the Commission any request for confidential treatment
of information. Except for the issuance of the Securities contemplated by this Agreement no event, liability, fact, circumstance, occurrence
or development has occurred or exists or is reasonably expected to occur or exist with respect to the Company or its businesses, prospects,
properties, operations, assets or financial condition that would be required to be disclosed by the Company under applicable securities
laws at the time this representation is made or deemed made that has not been publicly disclosed.
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2.5.2. Recent
Securities Transactions, etc. Subsequent to the respective dates as of which information is given in the Registration Statement,
the Disclosure Package, and the Prospectus, and except as may otherwise be indicated or contemplated herein or disclosed in the Registration
Statement, the Disclosure Package, and the Prospectus, the Company has not: (i) issued any securities or incurred any liability or obligation,
direct or contingent, for borrowed money; or (ii) declared or paid any dividend or made any other distribution on or in respect to its
capital stock.
2.6 Disclosures
in Commission Filings. Since February 23, 2021, (i) none of the Company’s filings with the Commission contained any untrue
statement of a material fact or omitted to state any material fact necessary in order to make the statements therein, in light of the
circumstances under which they were made, not misleading; and (ii) the Company has made all filings with the Commission required under
the Exchange Act and the rules and regulations of the Commission promulgated thereunder (the “Exchange Act Regulations”).
2.7 Independent
Accountants. To the knowledge of the Company, MNP LLP (the “Auditor”), whose report is filed with the Commission
and included or incorporated by reference in the Registration Statement, the Disclosure Package, and the Prospectus, is an independent
registered public accounting firm as required by the Securities Act and the Securities Act Regulations and the Public Company Accounting
Oversight Board. The Auditor has not, during the periods covered by the financial statements included or incorporated by reference in
the Registration Statement, the Disclosure Package, and the Prospectus, provided to the Company any non-audit services, as such term
is used in Section 10A(g) of the Exchange Act. To the knowledge of the Company, the Auditor is independent in accordance with the auditors’
rules of professional conduct of the Chartered Professional Accountants of Ontario, is an independent public accountant as required under
the Canadian Securities Laws of the Provinces of British Columbia, Alberta, Manitoba, New Brunswick, Newfoundland and Labrador, Nova
Scotia, Ontario, Prince Edward Island, Québec, Saskatchewan, and the Territories of the Yukon, Northwest Territories and Nunavut,
and there has never been a reportable event (within the meaning of National Instrument 51-102 Continuous Disclosure Obligations) between
the Company and the Auditor.
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2.8 Financial
Statements, etc. The consolidated financial statements, including the notes thereto and supporting schedules included or incorporated
by reference in the Registration Statement, the Disclosure Package, and the Prospectus, fairly present the financial position and the
results of operations of the Company at the dates and for the periods to which they apply; and such consolidated financial statements
have been prepared in conformity with U.S. generally accepted accounting principles (“GAAP”), consistently applied
throughout the periods involved (provided that unaudited interim financial statements are subject to year-end audit adjustments that
are not expected to be material in the aggregate and do not contain all footnotes required by GAAP); and the supporting schedules included
or incorporated by reference in the Registration Statement present fairly the information required to be stated therein. No other historical
or pro forma financial statements or supporting schedules are required to be included in the Registration Statement, the Disclosure Package,
or the Prospectus under the Securities Act or the Securities Act Regulations. The pro forma and pro forma as adjusted financial information
and the related notes, if any, included or incorporated by reference in the Registration Statement, the Disclosure Package, and the Prospectus
have been properly compiled and prepared in accordance with the applicable requirements of the Securities Act and the Securities Act
Regulations, the Exchange Act, and the Exchange Act Regulations and present fairly the information shown therein, and the assumptions
used in the preparation thereof are reasonable and the adjustments used therein are appropriate to give effect to the transactions and
circumstances referred to therein. All disclosures contained in the Registration Statement, the Disclosure Package, or the Prospectus,
or incorporated or deemed incorporated by reference therein, regarding “non-GAAP financial measures” (as such term is defined
by the rules and regulations of the Commission), if any, comply with Regulation G of the Exchange Act and Item 10 of Regulation S-K of
the Securities Act, to the extent applicable. Each of the Registration Statement, the Disclosure Package, and the Prospectus discloses
all material off-balance sheet transactions, arrangements, obligations (including contingent obligations), and other relationships of
the Company with unconsolidated entities or other persons that may have a material current or future effect on the Company’s financial
condition, changes in financial condition, results of operations, liquidity, capital expenditures, capital resources, or significant
components of revenues or expenses. Except as disclosed in the Registration Statement, the Disclosure Package, and the Prospectus, (a)
neither the Company nor any of its direct and indirect subsidiaries, including each entity disclosed or described in the Registration
Statement, the Disclosure Package, and the Prospectus as being a subsidiary of the Company (each, a “Subsidiary” and,
collectively, the “Subsidiaries”), has incurred any material liabilities or obligations, direct or contingent, or
entered into any material transactions other than in the ordinary course of business, (b) the Company has not declared or paid any dividends
or made any distribution of any kind with respect to its capital stock, (c) there has not been any change in the capital stock of the
Company or any of its Subsidiaries, or, other than in the usual course of business any grants under any stock compensation plan, and
(d) there has not been any Material Adverse Change in the Company’s long-term or short-term debt.
2.9 Authorized
Capital; Options, etc. The Company had, at the date or dates indicated in the Registration Statement, the Disclosure Package, and
the Prospectus, the duly authorized, issued, and outstanding capitalization as set forth therein. Based on the assumptions stated in
the Registration Statement, the Disclosure Package, and the Prospectus, the Company will have on the Closing Date the adjusted stock
capitalization set forth therein. Except as set forth in, or contemplated by, the Registration Statement, the Disclosure Package, and
the Prospectus, on the date hereof, as of the Applicable Time and on the Closing Date there will be no stock options, warrants, or other
rights to purchase or otherwise acquire any authorized, but unissued Common Shares of the Company or any security convertible or exercisable
into Common Shares of the Company, or any contracts or commitments to issue or sell Common Shares or any such options, warrants, rights,
or convertible securities.
2.10 Valid
Issuance of Securities, etc.
2.10.1. Outstanding
Securities. All issued and outstanding securities of the Company issued prior to the transactions contemplated by this Agreement
have been duly authorized and validly issued and are fully paid and non-assessable and have been issued in compliance with all United
States federal and state securities laws and all Canadian provincial securities laws; the holders thereof have no rights of rescission,
rights of first refusal, rights of participation or similar rights with respect thereto or put rights, and are not subject to personal
liability by reason of being such holders; and none of such securities were issued in violation of the preemptive rights, rights of first
refusal, or rights of participation or similar rights of any holders of any security of the Company or similar contractual rights granted
by the Company. The authorized Common Shares conform in all material respects to all statements relating thereto contained in the Registration
Statement, the Disclosure Package, and the Prospectus. The offers and sales of the outstanding Common Shares were at all relevant times
either registered under the Securities Act and the applicable state securities or “blue sky” laws, applicable Canadian Securities
Laws, or, based in part on the representations and warranties of the purchasers of such Common Shares, exempt from such registration
requirements.
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2.10.2. Securities
Sold Pursuant to this Agreement. The Securities and the Placement Agent’s Securities have been duly authorized for issuance
and sale and, when issued and paid for, will be validly issued, fully paid, and
non-assessable; the holders thereof are not and will not be subject to personal liability by reason of being such holders; the Securities
and the Placement Agent’s Securities are not and will not be subject to the preemptive rights of any holders of any security of
the Company or similar contractual rights granted by the Company; and all corporate action required to be taken for the authorization,
issuance, and sale of the Securities and the Placement Agent’s Securities
has been duly and validly taken. The Securities and the Placement Agent’s Securities conform in all material respects to all statements
with respect thereto contained in the Registration Statement, the Disclosure Package,
and the Prospectus. All corporate actions required to be taken for the authorization, issuance and sale of the Placement Agent’s
Warrant and the Pre-Funded Warrants have been duly and validly taken; the Warrant Shares and the Placement Agent’s Warrant Shares
have been duly authorized and reserved for issuance by all necessary corporate action on the part of the Company and when paid for and
issued in accordance with the Pre-Funded Warrant Certificate and the Placement Agent’s Warrant Agreement, as applicable, such Warrant
Shares and/or Placement Agent’s Warrant Shares, as the case may be, will be validly issued, fully paid and non-assessable common
shares in the capital of the Company; the holders thereof are not and will not be subject to personal liability by reason of being such
holders; and such Warrant Shares and/or Placement Agent’s Warrant Shares are not and will not be subject to the preemptive rights
of any holders of any security of the Company or similar contractual rights granted by the Company.
2.11 Registration
Rights of Third Parties. No holders of any securities of the Company or any rights exercisable for or convertible or exchangeable
into securities of the Company have the right to require the Company to register any such securities of the Company under the Securities
Act or to include any such securities in a registration statement to be filed by the Company.
2.12 Validity
and Binding Effect of Agreements. This Agreement, the Pre-Funded Warrant Certificates and the Placement Agent’s Warrant Agreement
have been duly and validly authorized by the Company, and, when executed and delivered, will constitute, the valid and binding agreements
of the Company, enforceable against the Company in accordance with their respective terms, except: (i) as such enforceability may be
limited by bankruptcy, insolvency, reorganization, or similar laws affecting creditors’ rights generally; (ii) as enforceability
of any indemnification or contribution provision may be limited under the federal and state securities laws; and (iii) that the remedy
of specific performance and injunctive and other forms of equitable relief may be subject to the equitable defenses and to the discretion
of the court before which any proceeding therefor may be brought.
2.13 No
Conflicts, etc. The execution, delivery, and performance by the Company of this Agreement, the Pre-Funded Warrant Certificates, the
Placement Agent’s Warrant Agreement and all ancillary documents, the consummation by the Company of the transactions herein and
therein contemplated and the compliance by the Company with the terms hereof and thereof do not and will not, with or without the giving
of notice or the lapse of time or both: (i) result in a material breach of, or conflict with any of the terms and provisions of, or constitute
a material default under, or result in the creation, modification, termination, or imposition of any lien, charge, mortgage, pledge,
security interest, claim, equity, trust, or other encumbrance, preferential arrangement, defect, or restriction of any kind whatsoever
or encumbrance upon any property or assets of the Company pursuant to the terms of any indenture, mortgage, deed of trust, note, lease,
loan agreement, or any other agreement or instrument, franchise, license, or permit to which the Company is a party or as to which any
property of the Company is a subject; (ii) result in any violation of the provisions of the Company’s Notice of Articles or Articles
(as the same may be amended or restated from time to time, collectively, the “Charter”); or (iii) violate any existing
applicable law, rule, regulation, judgment, order, or decree of any Governmental Entity as of the date hereof (including, without limitation,
those promulgated by the Food and Drug Administration of the U.S. Department of Health and Human Services (the “FDA”)
or by any foreign, federal, state, or local regulatory authority performing functions similar to those performed by the FDA).
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2.14 Regulatory.
Except as described in the Registration Statement, the Disclosure Package and the Prospectus: (i) the Company has not received notice
from any Governmental Entity alleging or asserting noncompliance with any Applicable Regulations (as defined in clause (ii) below) or
Authorizations (as defined in clause (iii) below); (ii) the Company is and has been in material compliance with federal, state, provincial
or foreign statutes, laws, ordinances, rules and regulations applicable to the Company (collectively, “Applicable Regulations”);
(iii) the Company possesses all licenses, certificates, approvals, clearances, consents, authorizations, qualifications, registrations,
permits, and supplements or amendments thereto required by any such Applicable Regulations and/or to carry on its businesses as now conducted
(“Authorizations”) and such Authorizations are valid and in full force and effect and the Company is not in violation
of any term of any such Authorizations; (iv) the Company has not received notice of any claim, action, suit, proceeding, hearing, enforcement,
investigation, arbitration or other action from any Governmental Entity or third party alleging that any product, operation or activity
conducted by the Company is in violation of any Applicable Regulations or Authorizations or has any knowledge that any such Governmental
Entity or third party is considering any such claim, litigation, arbitration, action, suit, investigation or proceeding, nor, has there
been any material noncompliance with or violation of any Applicable Regulations by the Company that could reasonably be expected to require
the issuance of any such communication or result in an investigation, corrective action, or enforcement action by any Governmental Entity;
and (v) the Company has not received notice that any Governmental Entity has taken, is taking or intends to take action to limit, suspend,
modify or revoke any Authorizations or has any knowledge that any such Governmental Entity has threatened or is considering such action.
Neither the Company nor any of its directors, officers, employees or agents has been convicted of any crime under any Applicable Regulations.
2.15 No
Defaults; Violations. No material default exists in the due performance and observance of any term, covenant, or condition of any
material license, contract, indenture, mortgage, deed of trust, note, loan, or credit agreement, or any other agreement or instrument
evidencing an obligation for borrowed money, or any other material agreement or instrument to which the Company is a party or by which
the Company may be bound or to which any of the properties or assets of the Company is subject. The Company is not (i) in violation of
any term or provision of its Charter, or (ii) in violation of any franchise, license, permit, applicable law, rule, regulation, judgment,
order or decree of any Governmental Entity.
2.16 Corporate
Power; Licenses; Consents.
2.16.1. Conduct
of Business. The Company has all requisite corporate power and authority, and has all necessary authorizations, approvals, registrations,
orders, licenses, certificates, qualifications, registrations and permits of and from all governmental regulatory officials and bodies
that it needs as of the date hereof to conduct its business purpose as described in the Registration Statement, the Disclosure Package,
and the Prospectus, except where such failure to have such consents, authorizations, approvals, registrations, orders, licenses, certificates,
qualifications, registrations, and permits would not reasonably be expected to result in a Material Adverse Change.
2.16.2. Transactions
Contemplated Herein. The Company has all corporate power and authority to enter into this Agreement, the Pre-Funded Warrant Certificates
and the Placement Agent’s Warrant Agreement and to carry out the provisions and conditions hereof and thereof, and all consents,
authorizations, approvals, registrations, orders, licenses, certificates, qualifications, regulations and permits required in connection
therewith have been obtained. No consent, authorization, or order of, and no filing with, any court, government agency, or other body
is required for the valid issuance, sale, and delivery of the Securities and the Placement Agent’s Warrant Agreement, and the consummation
of the transactions and agreements contemplated by this Agreement, the Pre-Funded Warrant Certificates and the Placement Agent’s
Warrant Agreement and as contemplated by the Registration Statement, the Disclosure Package, and the Prospectus, except with respect
to applicable federal and state securities laws and the rules and regulations of the Exchange and the Financial Industry Regulatory Authority,
Inc. (“FINRA”), and the policies of the TSX.
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2.17 D&O
Questionnaires. To the Company’s knowledge, all information contained in the questionnaires (the “Questionnaires”)
completed by each of the Company’s directors and officers immediately prior to the Offering (the “Insiders”),
as supplemented by all information concerning the Company’s directors, officers, and principal shareholders as described in the
Registration Statement, the Disclosure Package, and the Prospectus, as well as in each applicable Lock-Up Agreement (as defined in Section
2.27 below) provided to the Placement Agent, is true and correct in all material respects and the Company has not become aware of
any information which would cause the information disclosed in the Questionnaires to become materially inaccurate and incorrect.
2.18 Litigation;
Governmental Proceedings. There is no action, suit, proceeding, inquiry, arbitration, investigation, litigation, or governmental
proceeding pending or, to the Company’s knowledge, threatened against, or involving the Company or, to the Company’s knowledge,
any executive officer or director which has not been disclosed in the Registration Statement, the Disclosure Package, and the Prospectus,
or in connection with the Company’s listing application for the listing of the Securities on the Exchange or the TSX, or which
adversely affects or challenges the legality, validity or enforceability of this Agreement, the Pre-Funded Warrant Certificates, the
Placement Agent’s Warrant or the Securities.
2.19 Good
Standing. The Company has been duly incorporated and is validly existing as a corporation and is in good standing under the laws
of the Province of British Columbia as of the date hereof, and is duly qualified to do business and is in good standing in each other
jurisdiction in which its ownership or lease of property or the conduct of business requires such qualification, except where the failure
to be so qualified or in good standing, singularly or in the aggregate, would not have or reasonably be expected to result in a Material
Adverse Change.
2.20 Insurance.
The Company carries or is entitled to the benefits of insurance, with reputable insurers, in such amounts and covering such risks which
the Company believes are adequate, including, but not limited to, directors and officers insurance coverage at least equal to US$5,000,000
and all such insurance is in full force and effect. The Company has no reason to believe that it will not be able (i) to renew its existing
insurance coverage as and when such policies expire or (ii) to obtain comparable coverage from similar institutions as may be necessary
or appropriate to conduct its business as now conducted and at a cost that would not result in a Material Adverse Change.
2.21 Transactions
Affecting Disclosure to FINRA.
2.21.1. Finder’s
Fees. Except as described in the Registration Statement, the Disclosure Package, and the Prospectus, there are no claims, payments,
arrangements, agreements, or understandings relating to the payment of a finder’s, consulting, or origination fee by the Company
or any Insider with respect to the sale of the Securities hereunder or any other arrangements, agreements, or understandings of the Company
or, to the Company’s knowledge, any of its shareholders that may affect the Placement Agent’s compensation, as determined
by FINRA.
2.21.2. Payments
Within Twelve (12) Months. Except as described in the Registration Statement, the Disclosure Package, and the Prospectus, the Company
has not made any direct or indirect payments (in cash, securities, or otherwise) to: (i) any person, as a finder’s fee, consulting
fee, or otherwise, in consideration of such person raising capital for the Company or introducing to the Company persons who raised or
provided capital to the Company; (ii) any FINRA member; or (iii) any person or entity that has any direct or indirect affiliation or
association with any FINRA member, within the twelve (12) months prior to the date of this Agreement, other than the payment to the Placement
Agent as provided hereunder in connection with the Offering.
2.21.3. Use
of Proceeds. None of the net proceeds of the Offering will be paid by the Company to any participating FINRA member or its affiliates,
except as specifically authorized herein.
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2.21.4. FINRA
Affiliation. There is no (i) officer or director of the Company, (ii) beneficial owner of five percent (5%) or more of any class
of the Company’s securities or (iii) to the Company’s knowledge, beneficial owner of the Company’s unregistered equity
securities which were acquired during the 180-day period immediately preceding the filing of the Registration Statement that is an affiliate
or associated person of a FINRA member participating in the Offering (as determined in accordance with the rules and regulations of FINRA).
The Company (i) does not have any material lending or other relationship with any bank or lending affiliate of the Placement Agent and
(ii) does not intend to use any of the proceeds from the sale of the Securities to repay any outstanding debt owed to any affiliate of
the Placement Agent.
2.21.5. Information.
All information provided by the Company in its and, to the Company’s knowledge, all information provided in the Company’s
officers’ and directors’ FINRA questionnaires to Placement Agent Counsel specifically for use by Placement Agent Counsel
in connection with its Public Offering System filings (and related disclosure) with FINRA is true, correct, and complete in all material
respects.
2.22 Foreign
Corrupt Practices Act.
2.22.1. None
of the Company and its Subsidiaries or, to the Company’s knowledge, any director, officer, agent, employee, or affiliate of the
Company and its Subsidiaries or any other person acting on behalf of the Company and its Subsidiaries, has, directly or indirectly, given
or agreed to give any money, gift, or similar benefit (other than legal price concessions to customers in the ordinary course of business)
to any customer, supplier, employee, or agent of a customer or supplier, or official or employee of any governmental agency or instrumentality
of any government (domestic or foreign) or any political party or candidate for office (domestic or foreign) or other person who was,
is, or may be in a position to help or hinder the business of the Company (or assist it in connection with any actual or proposed transaction)
that (i) might subject the Company to any damage or penalty in any civil, criminal, or governmental litigation or proceeding, (ii) if
not given in the past, might have had a Material Adverse Change; (iii) if not continued in the future, might adversely affect the assets,
business, operations, or prospects of the Company.
2.22.2. The
Company has taken reasonable steps to ensure that its accounting controls and procedures are sufficient to cause the Company to comply
in all material respects with the Foreign Corrupt Practices Act of 1977, as amended, and the rules and regulations thereunder (collectively,
the “FCPA”) and neither it nor any of its employees have (i) violated or is in violation of any provision of the FCPA
or any applicable non-U.S. anti-bribery statute or regulation; (ii) made any bribe, rebate, payoff, influence payment, kickback or other
unlawful payment; or (iii) received notice of any investigation, proceeding or inquiry by any Governmental Entity regarding any of the
matters in clauses (i)-(iii) above; and the Company and, to the knowledge of the Company, the Company’s affiliates have conducted
their respective businesses in compliance with the FCPA and have instituted and maintain policies and procedures designed to ensure,
and which are reasonably expected to continue to ensure, continued compliance therewith. The Company has taken reasonable steps to ensure
that its accounting controls and procedures are sufficient to cause the Company to comply in all material respects with the Foreign Corrupt
Practices Act of 1977, as amended.
2.23 Compliance
with OFAC. None of the Company and any of its Subsidiaries or, to the Company’s knowledge, any director, officer, agent, employee,
or affiliate of the Company and its Subsidiaries or any other person acting on behalf of the Company and any of its Subsidiaries, is
currently subject to any U.S. sanctions administered by the Office of Foreign Assets Control of the U.S. Department of the Treasury (“OFAC”),
and the Company will not, directly or indirectly, use the proceeds of the Offering hereunder, or lend, contribute, or otherwise make
available such proceeds to any subsidiary, joint venture partner, or other person or entity, for the purpose of financing the activities
of any person currently subject to any U.S. sanctions administered by OFAC.
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2.24 Forward-Looking
Statements. No forward-looking statement (within the meaning of Section 27A of the Securities Act and Section 21E of the Exchange
Act) contained in either the Registration Statement, Disclosure Package, or Prospectus has been made or reaffirmed without a reasonable
basis or has been disclosed other than in good faith.
2.25 Money
Laundering Laws. The operations of the Company and its Subsidiaries are and have been conducted at all times in compliance with applicable
financial recordkeeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, the money
laundering statutes of all jurisdictions, the rules and regulations thereunder and any related or similar rules, regulations, or guidelines,
issued, administered, or enforced by any Governmental Entity (collectively, the “Money Laundering Laws”); and
no action, suit, or proceeding by or before any Governmental Entity involving the Company with respect to the Money Laundering Laws is
pending or, to the best knowledge of the Company, threatened.
2.26 Regulatory.
2.26.1. All
preclinical studies and clinical trials conducted by or on behalf of the Company that are material to the Company and its Subsidiaries,
taken as a whole, are or have been adequately described in the Registration Statement, the Disclosure Package, and the Prospectus in
all material respects. The preclinical studies and clinical trials conducted by or on behalf of the Company and its Subsidiaries that
are described in the Registration Statement, the Disclosure Package, and the Prospectus or the results of which are referred to in the
Registration Statement, the Disclosure Package, and the Prospectus were and, if still ongoing, are being conducted in material compliance
with all laws and regulations applicable thereto in the jurisdictions in which they are being conducted and with all laws and regulations
applicable to preclinical studies and clinical trials from which data will be submitted to support marketing approval. The descriptions
in the Registration Statement, the Disclosure Package, and the Prospectus of the results of such studies are accurate and complete in
all material respects and fairly present the data derived from such studies, and the Company has no knowledge of, or reason to believe
that, the aggregate results of any large well-controlled clinical study are inconsistent with or otherwise call into question the results
of any clinical study conducted by or on behalf of the Company that is described in the Registration Statement, the Disclosure Package,
and the Prospectus or the results of which are referred to in the Registration Statement, the Disclosure Package, and the Prospectus.
Except as disclosed in the Registration Statement, the Disclosure Package, and the Prospectus, the Company has not received any notices
or statements from the FDA, the European Medicines Agency (“EMA”), or any other governmental agency or authority imposing,
requiring, requesting, or suggesting a clinical hold, termination, suspension, or material modification for or of any preclinical studies
and clinical trials that are described in the Registration Statement, the Disclosure Package, and the Prospectus or the results of which
are referred to in the Registration Statement, the Disclosure Package, and the Prospectus. Except as disclosed in the Registration Statement,
the Disclosure Package, and the Prospectus, the Company has not received any notices or statements from the FDA, the EMA, or any other
governmental agency, and otherwise has no knowledge of, or reason to believe that, (i) any investigational new drug application for any
potential product of the Company is or has been rejected or placed on clinical hold; and (ii) any license, approval, permit, or authorization
to conduct any clinical trial of any potential product of the Company has been, will be, or may be suspended, revoked, modified, or limited.
Neither the Company nor any of its subsidiaries has failed to file with the FDA or any foreign, federal, state, or local governmental
or regulatory authority performing functions similar to those performed by the FDA, any filing, declaration, listing, registration, report,
or submission that is required to be so filed. All such filings were in material compliance with applicable laws when filed and no deficiencies
have been asserted by any applicable regulatory authority (including, without limitation, the FDA or any foreign, federal, state, or
local governmental or regulatory authority performing functions similar to those performed by the FDA) with respect to any such filings,
declarations, listings, registrations, reports, or submissions. To the knowledge of the Company, there are no facts that would be reasonably
likely to result in any warning, untitled or notice of violation letter or Form FDA-483 from the FDA. The Company is not aware of any
studies, tests, or trials the results of which the Company believes reasonably call into question (i) the study, test, or trial results
of any of its products, (ii) the efficacy or safety of any of its products, or (iii) any of the Company’s filings with any Governmental
Entity.
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2.26.2. Regulatory
Filings and Permits. The Company and its Subsidiaries have such permits, licenses, clearances, registrations, exemptions, patents,
franchises, certificates of need and other approvals, consents, and other authorizations (“Permits”) issued by the
appropriate domestic or foreign regional, federal, state, or local regulatory agencies or bodies necessary to conduct the business of
the Company, including, without limitation, any Investigational New Drug Application (an “IND”), Biologics License
Application (“BLA”), and/or New Drug Application (an “NDA”), as required by FDA, the Drug Enforcement
Administration (the “DEA”), or any other Permits issued by domestic or foreign regional, federal, state, or local
agencies or bodies engaged in the regulation of pharmaceuticals such as those being developed by the Company and its Subsidiaries (collectively,
the “Regulatory Permits”), except for any of the foregoing that would not reasonably be expected to, individually
or in the aggregate, have a material adverse effect on the assets, business or operations of the Company taken as a whole (a “Material
Adverse Effect”); the Company is in compliance in all material respects with the requirements of the Regulatory Permits, and
all of such Regulatory Permits are valid and in full force and effect; the Company has not received any notice of proceedings relating
to the revocation, termination, modification, or impairment of rights of any of the Regulatory Permits that, individually or in the aggregate,
if the subject of an unfavorable decision, ruling, or finding, would reasonably be expected to result in a Material Adverse Effect; the
Company has not failed to submit to the FDA any IND, BLA, or NDA necessary to conduct the business of the Company, any such filings that
were required to be made were in material compliance with applicable laws when filed, and no material deficiencies have been asserted
by the FDA with respect to any such filings or submissions that were made.
2.26.3. Compliance
with Health Care Laws. Each of the Company and its Subsidiaries is, and at all times has been, in compliance in all material respects
with all applicable Health Care Laws, and has not engaged in activities which are, as applicable, cause for false claims liability, civil
penalties, or mandatory or permissive exclusion from Medicare, Medicaid, or any other state or federal health care program. For purposes
of this Agreement, “Health Care Laws” means: (i) the Federal Food, Drug, and Cosmetic Act (21 U.S.C. §§
301 et seq.), the Public Health Service Act (42 U.S.C. §§ 201 et seq.), and the regulations promulgated thereunder; (ii) all
applicable federal, state, local, and all applicable foreign health care related fraud and abuse laws, including, without limitation,
the U.S. Anti-Kickback Statute (42 U.S.C. Section 1320a-7b(b)), the U.S. Physician Payment Sunshine Act (42 U.S.C. § 1320a-7h),
the U.S. Civil False Claims Act (31 U.S.C. Section 3729 et seq.), the criminal False Claims Law (42 U.S.C. § 1320a- 7b(a)), all
criminal laws relating to health care fraud and abuse, including but not limited to 18 U.S.C. Sections 286 and 287, and the health care
fraud criminal provisions under the U.S. Health Insurance Portability and Accountability Act of 1996 (“HIPAA”) (42 U.S.C.
Section 1320d et seq.), the exclusion laws (42 U.S.C. § 1320a-7), the civil monetary penalties law (42 U.S.C. § 1320a-7a),
HIPAA, as amended by the Health Information Technology for Economic and Clinical Health Act (42 U.S.C. Section 17921 et seq.), and the
regulations promulgated pursuant to such statutes; (iii) Medicare (Title XVIII of the Social Security Act); (iv) Medicaid (Title XIX
of the Social Security Act); (v) the Controlled Substances Act (21 U.S.C. §§ 801 et seq.) and the regulations promulgated thereunder;
and (vi) any and all other applicable health care laws and regulations. Neither the Company nor, to the knowledge of the Company, any
subsidiary has received notice of any claim, action, suit, litigation, proceeding, hearing, enforcement, investigation, inquiry, arbitration,
or other action from any court or arbitrator or governmental or regulatory authority or third party alleging that any product operation
or activity conducted by the Company is in material violation of any Health Care Laws, and, to the Company’s knowledge, no such
claim, action, suit, proceeding, hearing, enforcement, investigation, arbitration, or other action is threatened. Neither the Company
nor, to the knowledge of the Company, any subsidiary is a party to or has any ongoing reporting obligations pursuant to any corporate
integrity agreements, deferred prosecution agreements, monitoring agreements, consent decrees, settlement orders, plans of correction,
or similar agreements with or imposed by any governmental or regulatory authority. Additionally, neither the Company, its Subsidiaries,
nor any of its respective employees, officers, or directors has been excluded, suspended, or debarred from participation in any U.S.
federal health care program or human clinical research or, to the knowledge of the Company, is subject to a governmental inquiry, investigation,
proceeding, or other similar action that could reasonably be expected to result in debarment, suspension, or exclusion.
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2.27 Officers’
Certificate. Any certificate signed by any duly authorized officer of the Company and delivered to the Placement Agent or to Placement
Agent Counsel shall be deemed a representation and warranty by the Company to the Placement Agent as to the matters covered thereby.
2.28 Lock-Up
Agreements. Schedule 3 hereto contains a complete and accurate list of the Company’s executive officers and directors who will
be subject to the Lock-Up Agreement (as defined below) (collectively, the “Lock-Up Parties”). The Company has caused
or will cause each of the Lock-Up Parties to deliver to the Placement Agent an executed Lock-Up Agreement, in the form attached hereto
as Exhibit A (the “Lock-Up Agreement”), prior to, or concurrently with, the execution of this Agreement.
2.29 Subsidiaries.
All direct and indirect Subsidiaries of the Company are duly organized and in good standing under the laws of the place of organization
or incorporation, and each Subsidiary is in good standing in each jurisdiction in which its ownership or lease of property or the conduct
of business requires such qualification, except where the failure to be so qualified, singularly or in the aggregate, would not have
or reasonably be expected to result in a Material Adverse Change. The Company’s ownership and control of each Subsidiary is as
described in the Registration Statement, the Disclosure Package, and the Prospectus.
2.30 Related
Party Transactions.
2.30.1. Business
Relationships. There are no business relationships or related party transactions involving the Company or any other person required
to be described in the Registration Statement, the Disclosure Package, and the Prospectus that have not been described as required.
2.30.2. No
Relationships with Customers and Suppliers. No relationship, direct or indirect, exists between or among the Company on the one hand,
and the directors, officers, five percent (5%) or greater shareholders, customers, or suppliers of the Company or any of the Company’s
affiliates on the other hand, which is required to be described in the Disclosure Package, and the Prospectus or a document incorporated
by reference therein and which is not so described.
2.30.3. No
Unconsolidated Entities. There are no transactions, arrangements, or other relationships between and/or among the Company, any of
its affiliates (as such term is defined in Rule 405 of the Securities Act Regulations) and any unconsolidated entity, including, but
not limited to, any structured finance, special purpose, or limited purpose entity that could reasonably be expected to materially affect
the Company’s or any of its Subsidiaries’ liquidity or the availability of or requirements for their capital resources required
to be described or incorporated by reference in the Registration Statement, the Disclosure Package, and the Prospectus which have not
been described or incorporated by reference as required.
2.30.4. No
Loans or Advances to Affiliates. There are no outstanding loans, advances (except normal advances for business expenses in the ordinary
course of business), or guarantees or indebtedness by the Company to or for the benefit of any of the officers or directors of the Company,
any other affiliates of the Company or any of their respective family members, except as disclosed in the Registration Statement, the
Disclosure Package, and the Prospectus.
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2.31 Board
of Directors. The Board is comprised of the persons disclosed in the Registration Statement, the Disclosure Package, and the Prospectus.
The qualifications of the persons serving as board members and the overall composition of the Board comply with the Exchange Act, the
Exchange Act Regulations, and the Sarbanes-Oxley Act of 2002 and the rules promulgated thereunder (the “Sarbanes-Oxley Act”)
applicable to the Company and the listing rules of the Exchange. At least one (1) member of the Audit Committee of the Board qualifies
as an “audit committee financial expert,” as such term is defined under Regulation S-K and the listing rules of the Exchange.
In addition, at least a majority of the persons serving on the Board qualify as “independent,” as defined under the listing
rules of the Exchange.
2.32 Sarbanes-Oxley
Compliance.
2.32.1. Disclosure
Controls. The Company has developed and currently maintains disclosure controls and procedures that will comply with Rule 13a-15
or 15d-15 under the Exchange Act Regulations, and such controls and procedures are effective to ensure that all material information
concerning the Company will be made known on a timely basis to the individuals responsible for the preparation of the Company’s
Exchange Act filings and other public disclosure documents.
2.32.2. Compliance.
The Company is, or at the Applicable Time and on the Closing Date will be, in material compliance with the provisions of the Sarbanes-Oxley
Act applicable to it, and has implemented or will implement such programs and taken reasonable steps to ensure the Company’s future
compliance (not later than the relevant statutory and regulatory deadlines therefor) with all of the material provisions of the Sarbanes-Oxley
Act.
2.32.3. Accounting
Controls. The Company and its Subsidiaries maintain systems of “internal control over financial reporting” (as defined
under Rules 13a-15 and 15d-15 under the Exchange Act Regulations) that comply with the requirements of the Exchange Act and have been
designed by, or under the supervision of, their respective principal executive and principal financial officers, or persons performing
similar functions, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial
statements for external purposes in accordance with GAAP, including, but not limited to, internal accounting controls sufficient to provide
reasonable assurance that (i) transactions are executed in accordance with management’s general or specific authorizations;
(ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with GAAP and to maintain asset
accountability; (iii) access to assets is permitted only in accordance with management’s general or specific authorization;
and (iv) the recorded accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is
taken with respect to any differences. Except as disclosed in the Registration Statement, the Disclosure Package, and the Prospectus,
the Company is not aware of any material weaknesses in its internal controls. The Auditor and the Audit Committee of the Board have been
advised of: (i) all significant deficiencies and material weaknesses in the design or operation of internal controls over financial reporting
which are known to the Company’s management and that have adversely affected or are reasonably likely to adversely affect the Company’s
ability to record, process, summarize, and report financial information; and (ii) any fraud known to the Company’s management,
whether or not material, that involves management or other employees who have a significant role in the Company’s internal controls
over financial reporting. Since the date of the latest audited financial statements included or incorporated by reference in the Disclosure
Package, there has been no change in the Company’s internal control over financial reporting that has materially affected, or is
reasonably likely to materially affect, the Company’s internal control over financial reporting.
2.33 No
Investment Company Status. The Company is not and, after giving effect to the Offering and the application of the proceeds thereof
as described in the Registration Statement, the Disclosure Package, and the Prospectus, will not be, required to register as an “investment
company,” as defined in the Investment Company Act of 1940, as amended.
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2.34 No
Labor Disputes. No labor dispute with the employees of the Company or any of its Subsidiaries exists or, to the knowledge of the
Company, is imminent. To the knowledge of the Company, no executive officer of the Company is, or is now expected to be, in violation
of any material term of any employment contract, confidentiality, disclosure or proprietary information agreement or non-competition
agreement, or any other contract or agreement or any restrictive covenant in favor of any third party, and the continued employment of
each such executive officer does not subject the Company to any liability with respect to any of the foregoing matters. The Company is
in material compliance with all federal, state, provincial, local and foreign laws and regulations relating to employment and employment
practices, terms and conditions of employment and wages and hours.
2.35 Employment
Benefit Laws. The Company is not in violation of or has not received notice of any violation with respect to any federal, state,
provincial or foreign law relating to discrimination in the hiring, promotion or pay of employees, nor any applicable federal, state,
provincial or foreign wages and hours law, nor any state law precluding the denial of credit due to the neighborhood in which a property
is situated, the violation of any of which could reasonably be expected to have a Material Adverse Change.
2.36 Intellectual
Property Rights.
2.36.1. Title,
License or Right to Use. The Company and each of its Subsidiaries own, have valid and enforceable title to, license to, or otherwise
have the right to use, all patents, patent applications, inventions, all rights, whether conveyed by operation of law or contract, to
any and all inventions made by an employee working in the scope of his or her employment, trademarks, service marks, trade names, corporate
names, trademark registrations, trademark applications, service mark registrations, logos, trade dress, designs, data, database rights,
Internet domain names, websites, web content, copyrights, moral rights, works of authorship, licenses, proprietary information and know-how
(including trade secrets and other unpatented and/or unpatentable proprietary or confidential information, systems or procedures), and
all other worldwide intellectual property and proprietary rights, including registrations and applications for registration thereof (including
all rights pertaining to the foregoing anywhere in the world, including rights arising under international treaties and conventions),
and all common law rights to intellectual property and associated goodwill (collectively, “Intellectual Property”)
necessary for the conduct of their respective businesses as currently conducted and as currently proposed to be conducted, or which are
described in the Registration Statement, the Disclosure Package and the Prospectus as being owned by or licensed to the Company or its
Subsidiaries. Where the Company and its Subsidiaries own the Intellectual Property (the “Owned Intellectual Property”),
the Owned Intellectual Property is owned by the Company or its Subsidiaries as sole and exclusive owner with good, valid and marketable
title thereto, free and clear of all encumbrances. Where the Company or its Subsidiaries license the Intellectual Property (the “Licensed
Intellectual Property”), to the knowledge of the Company, the Company or its Subsidiaries have valid and enforceable licenses
to use the Licensed Intellectual Property used by it in connection with, and as required for business of the Company and its Subsidiaries.
No licenses have been granted by the Company or its Subsidiaries for the Owned Intellectual Property, except as described in the Registration
Statement, the Disclosure Package and the Prospectus.
2.36.2. No
Violation of Third Party Intellectual Property. The Company and its Subsidiaries conduct of their respective businesses as currently
conducted does not, and, to its knowledge will not infringe, misappropriate or otherwise violate any Intellectual Property Rights of
others. The Intellectual Property of the Company has not been adjudged by a court of competent jurisdiction to be invalid or unenforceable,
in whole or in part, and the Company is unaware of any facts which would form a reasonable basis for any such adjudication. To the knowledge
of the Company, no Person has infringed, misappropriated or violated the Owned Intellectual Property nor does such Owned Intellectual
Property infringe, misappropriate or violate the Intellectual Property of any third party. To the knowledge of the Company and its Subsidiaries,
there is no application pending of any other Person which would or would potentially interfere with or infringe any Owned Intellectual
Property. The Company and its Subsidiaries have not received any notice of any claim of infringement, misappropriation or conflict with
any intellectual property rights of another, and the Company is unaware of any facts which would form a reasonable basis for any such
notice or claim. To the Company’s knowledge, there are no third parties who have rights to any Intellectual Property, except for
customary reversionary rights of third-party licensors with respect to Intellectual Property that is disclosed in the Registration Statement,
the Disclosure Package and the Prospectus as owned by or licensed to the Company or its Subsidiaries.
19
2.36.3. No
Pending Action. Except as disclosed in the Registration Statement, the Disclosure Package and the Prospectus, there is no pending
or, to the Company’s knowledge, threatened action, suit, proceeding or claim by others: (i) challenging the Company’s rights
in or to any Intellectual Property, and the Company is unaware of any facts which would form a reasonable basis for any such action,
suit, proceeding or claim; (ii) challenging the validity, enforceability or scope of any Intellectual Property, and the Company is unaware
of any facts which would form a reasonable basis for any such action, suit, proceeding or claim; or (iii) asserting that the Company
or its Subsidiaries infringe, misappropriate, or otherwise violate, or would, upon the commercialization of any product or service described
in the Registration Statement, the Disclosure Package and the Prospectus as under development, infringe, misappropriate, or otherwise
violate, any Intellectual Property rights of others, and the Company is unaware of any facts which would form a reasonable basis for
any such action, suit, proceeding or claim.
2.36.4. Compliance;
No Material Defects. To the knowledge of the Company, the Company and its Subsidiaries have complied with the terms of each agreement
pursuant to which Intellectual Property has been licensed to the Company or its Subsidiaries, except as may not reasonably result in
a Material Adverse Effect, and all such agreements are in full force and effect. To the Company’s knowledge, there are no material
defects in any of the patents or patent applications included in the Intellectual Property. All registrations, filings and actions necessary
to preserve the rights of the Company and its Subsidiaries to its Owned Intellectual Property have been made or taken in accordance with
the provisions of any applicable law, rule, regulation, judgment, order or decree of any Governmental Entity and all such Owned Intellectual
Property is valid and subsisting, in compliance with any existing applicable law, rule, regulation, judgment, order or decree of any
Governmental Entity (including payment of filing, examination and maintenance fees and proofs of use) and is not subject to any unpaid
maintenance fees or taxes or actions.
2.36.5. Protection
of Intellectual Property. The Company and its Subsidiaries have taken all reasonable measures, in accordance with sound industry
practices, to protect, maintain and safeguard their Intellectual Property, including the execution of appropriate nondisclosure, confidentiality
agreements and invention assignment agreements and invention assignments with their employees or service providers. All employees and
other developers of Owned Intellectual Property have executed written contracts with the Company or its Subsidiaries which (i) protect
the confidentiality of all Intellectual Property, (ii) effect the full and irrevocable assignment to the Company and its Subsidiaries
of all of the Intellectual Property conceived or reduced to practice by them for the Company or its Subsidiaries; and (iii) provide that
employees and developers have waived all their non-assignable rights (including moral rights) in such Intellectual Property in favor
of the Company and its Subsidiaries.
2.36.6. Employees.
No employee of the Company or its Subsidiaries is in or has been in violation of any material term of any employment contract, patent
disclosure agreement, invention assignment agreement, non-competition agreement, non-solicitation agreement, nondisclosure agreement,
or any restrictive covenant to or with a former employer where the basis of such violation relates to such employee’s employment
with the Company or its Subsidiaries, as applicable.
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2.36.7. Duty
of Candor and Good Faith. The duty of candor and good faith as required by the United States Patent and Trademark Office during the
prosecution of the United States patents and patent applications within the Intellectual Property have been complied with; and in all
foreign offices having similar requirements, all such requirements have been complied with. None of the Company owned Intellectual Property
or technology (including information technology and outsourced arrangements) employed by the Company or its Subsidiaries has been obtained
or is being used by the Company or its Subsidiary in violation of any contractual obligation binding on the Company or its Subsidiaries
or any of their respective officers, directors or employees or otherwise in violation of the rights of any persons.
2.36.8. Trade
Secrets. The Company and its Subsidiaries have taken reasonable and customary actions to protect their rights in and prevent the
unauthorized use and disclosure of trade secrets and confidential business information (including confidential source code, ideas, research
and development information, know-how, formulas, compositions, technical data, designs, drawings, specifications, research records, records
of inventions, test information, financial, marketing and business data, customer and supplier lists and information, pricing and cost
information, business and marketing plans and proposals) owned by the Company and its Subsidiaries, and, there has been no unauthorized
use or disclosure of the trade secrets or confidential business information.
2.36.9. IT
Assets. Except as could not reasonably be expected to have a Material Adverse Effect, (i) the computers, software, servers, networks,
data communications lines, and other information technology systems owned, licensed, leased or otherwise used by the Company or its Subsidiaries
(excluding any public networks) (collectively, the “IT Assets”) operate and perform as is necessary for the operation
of the business of the Company and its Subsidiaries as currently conducted and as proposed to be conducted as described in the Registration
Statement, the Disclosure Package and the Prospectus, and (ii) to the knowledge of the Company, such IT Assets are not infected by viruses,
disabling code or other harmful code. The Company and its Subsidiaries have at all times implemented and maintained all industry standard
controls, policies, procedures, and safeguards to maintain and protect their confidential information and the integrity, continuous operation,
redundancy and security of all IT Assets and data (including all Personal Data (defined below) sensitive, confidential or regulated data
used in connection with their businesses, and there have been no breaches, violations, outages or unauthorized uses of or accesses to
same, except for those that have been remedied without material cost or liability or the duty to notify any other person, nor any incidents
under internal review or investigations relating to the same.
2.36.10. To
the Company’s knowledge, there has been no security breach or other compromise of or relating to any of the Company’s or
any Subsidiary’s information technology and computer systems, networks, hardware, software, data (including the data of its respective
customers, employees, suppliers, vendors and any third party data maintained by or on behalf of it), equipment or technology (collectively,
“IT Systems and Data”) and (y) the Company and the Subsidiaries have not been notified of, and has no knowledge of
any event or condition that would reasonably be expected to result in, any security breach or other compromise to its IT Systems and
Data; (ii) the Company and the Subsidiaries are presently in compliance with all applicable laws or statutes and all judgments, orders,
rules and regulations of any court or arbitrator or governmental or regulatory authority, internal policies and contractual obligations
relating to the privacy and security of IT Systems and Data and to the protection of such IT Systems and Data from unauthorized use,
access, misappropriation or modification, except as would not, individually or in the aggregate, have a Material Adverse Effect; (iii)
the Company and the Subsidiaries have implemented and maintained commercially reasonable safeguards to maintain and protect its material
confidential information and the integrity, continuous operation, redundancy and security of all IT Systems and Data; and (iv) the Company
and the Subsidiaries have implemented backup and disaster recovery technology consistent with commercially reasonable industry standards
and practices.
21
2.36.11. Data
Privacy and Security Laws. The Company and its Subsidiaries are, and at all prior times were, in material compliance with all applicable
state and federal data privacy and security laws and regulations in the United States, including without limitation the Health Insurance
Portability and Accountability Act of 1996 (“HIPAA”) as amended by the Health Information Technology for Economic
and Clinical Health Act, and all applicable provincial and federal data privacy and security laws and regulations in Canada, including
without limitation the Personal Information Protection and Electronic Documents Act (S.C. 2000, c. 5) (“PIPEDA”);
and the Company and its Subsidiaries have taken commercially reasonable actions to prepare to comply with, and have been and currently
are in compliance with, the European Union General Data Protection Regulation (“GDPR”) (EU 2016/679) (collectively,
the “Privacy Laws”). To ensure compliance with the Privacy Laws, the Company and its Subsidiaries have in place, comply
with, and take appropriate steps reasonably designed to ensure compliance in all material respects with their policies and procedures
relating to data privacy and security and the collection, storage, use, disclosure, handling, and analysis of Personal Data (the “Policies”).
“Personal Data” means (i) a natural person’s name, street address, telephone number, e-mail address, photograph, social
security number or tax identification number, driver’s license number, passport number, credit card number, bank information, or
customer or account number; (ii) any information which would qualify as “personally identifying information” under the Federal
Trade Commission Act, as amended; (iii) Protected Health Information as defined by HIPAA; (iv) “personal information”, “personal
health information”. and “business contact information” as defined by PIPEDA; (v) “personal data” as defined
by GDPR; and (vi) any other piece of information that allows the identification of such natural person, or his or her family, or permits
the collection or analysis of any data related to an identified person’s health or sexual orientation. The Company and its Subsidiaries
have at all times made all disclosures to users or customers required by applicable laws and regulatory rules or requirements, and none
of such disclosures made or contained in any Policy have, to the knowledge of the Company, been inaccurate or in violation of any applicable
laws and regulatory rules or requirements in any material respect. The Company further certifies that neither it nor any Subsidiary:
(i) has received notice of any actual or potential liability under or relating to, or actual or potential violation of, any of the Privacy
Laws, and has no knowledge of any event or condition that would reasonably be expected to result in any such notice; (ii) is currently
conducting or paying for, in whole or in part, any investigation, remediation, or other corrective action pursuant to any Privacy Law;
or (iii) is a party to any order, decree, or agreement that imposes any obligation or liability under any Privacy Law.
2.37 Clinical
Studies. All preclinical and clinical studies conducted by or on behalf of the Company and the Subsidiaries that are material to
an understanding of the Company’s business and an investment in the Company and the Subsidiaries, are or have been adequately described
in the Registration Statement, the Disclosure Package and the Prospectus in all material respects. To the Company’s knowledge,
after reasonable inquiry, the clinical and preclinical studies conducted by or on behalf of the Company and the Subsidiaries that are
described in the Registration Statement, the Disclosure Package and Prospectus or the results of which are referred to in the Registration
Statement, the Disclosure Package and the Prospectus were and, if still ongoing, are being conducted in material compliance with all
laws and regulations applicable thereto in the jurisdictions in which they are being conducted and with all laws and regulations applicable
to preclinical and clinical studies from which data will be submitted to support marketing approval. The descriptions in the Registration
Statement, the Disclosure Package and the Prospectus of the results of such studies are accurate and complete in all material respects
and fairly present the data derived from such studies, and Company has no knowledge of any large well-controlled clinical study the aggregate
results of which are inconsistent with or otherwise call into question the results of any clinical study conducted by or on behalf of
the Company that are described in the Registration Statement, the Disclosure Package and the Prospectus. Except as disclosed in the Registration
Statement, the Disclosure Package and the Prospectus, the Company has not received any notices or statements from the FDA, the European
Medicines Agency (“EMA”) or any other Governmental Entity imposing, requiring, requesting or suggesting a clinical hold,
termination, suspension or material modification for or of any clinical or preclinical studies that are described in the Registration
Statement, the Disclosure Package and the Prospectus or the results of which are referred to in the Registration Statement, the Disclosure
Package and the Prospectus, the Company and the Subsidiaries have not received any notices or statements from the FDA, the EMA or any
other Governmental Entity, and otherwise has no knowledge or reason to believe, that (i) any investigational new drug application for
potential product of the Company is or has been rejected or determined to be non-approvable or conditionally approvable; and (ii) any
license, approval, permit or authorization to conduct any clinical trial of any potential product of the Company has been, will be or
may be suspended, revoked, modified or limited.
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2.38 Taxes.
Each of the Company and its Subsidiaries has filed all returns (as hereinafter defined) required to be filed with taxing authorities
prior to the date hereof or has duly obtained extensions of time for the filing thereof. Each of the Company and its Subsidiaries has
paid all taxes (as hereinafter defined) shown as due on such returns that were filed and has paid all taxes imposed on or assessed against
the Company or such respective Subsidiary. The provisions for taxes payable, if any, shown on the financial statements filed with or
as part of the Registration Statement are sufficient for all accrued and unpaid taxes, whether or not disputed, and for all periods to
and including the dates of such consolidated financial statements. Except as disclosed in writing to the Placement Agent, (i) no issues
have been raised (and are currently pending) by any taxing authority in connection with any of the returns or taxes asserted as due from
the Company or its Subsidiaries, and (ii) no waivers of statutes of limitation with respect to the returns or collection of taxes have
been given by or requested from the Company or its Subsidiaries. The term “taxes” means all federal, state, local,
foreign and other net income, gross income, gross receipts, sales, use, ad valorem, transfer, franchise, profits, license, lease, service,
service use, withholding, payroll, employment, excise, severance, stamp, occupation, premium, property, windfall profits, customs, duties,
or other taxes, fees, assessments, or charges of any kind whatever, together with any interest and any penalties, additions to tax, or
additional amounts with respect thereto. The term “returns” means all returns, declarations, reports, statements,
and other documents required to be filed in respect to taxes.
2.39 ERISA
Compliance. The Company and any “employee benefit plan” (as defined under the Employee Retirement Income Security Act
of 1974, as amended, and the regulations and published interpretations thereunder (collectively, “ERISA”)) established
or maintained by the Company or its “ERISA Affiliates” (as defined below) are in compliance in all material respects with
ERISA. “ERISA Affiliate” means, with respect to the Company, any member of any group of organizations described in
Sections 414(b), (c), (m), or (o) of the Internal Revenue Code of 1986, as amended, and the regulations and published interpretations
thereunder (the “Code”) of which the Company is a member. No “reportable event” (as defined under ERISA)
has occurred or is reasonably expected to occur with respect to any “employee benefit plan” established or maintained by
the Company or any of its ERISA Affiliates. No “employee benefit plan” established or maintained by the Company or any of
its ERISA Affiliates, if such “employee benefit plan” were terminated, would have any “amount of unfunded benefit liabilities”
(as defined under ERISA). Neither the Company nor any of its ERISA Affiliates has incurred or reasonably expects to incur any material
liability under (i) Title IV of ERISA with respect to termination of, or withdrawal from, any “employee benefit plan” or
(ii) Sections 412, 4971, 4975, or 4980B of the Code. Each “employee benefit plan” established or maintained by the Company
or any of its ERISA Affiliates that is intended to be qualified under Section 401(a) of the Code is so qualified and, to the knowledge
of the Company, nothing has occurred, whether by action or failure to act, which would cause the loss of such qualification.
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2.40 Compliance
with Laws. The Company: (i) is and at all times has been in compliance with all statutes, rules, regulations and ordinances, and
all final non-appealable judgments, orders and decrees, of all Governmental Entities applicable to the Company, its Subsidiaries, or
the ownership, testing, development, manufacture, packaging, processing, use, distribution, marketing, labeling, promotion, sale, offer
for sale, storage, import, export, storage, or disposal of any product manufactured or distributed by the Company or its Subsidiaries
(“Applicable Laws”), except as could not, individually or in the aggregate, reasonably be expected to result in or
have a Material Adverse Change; (ii) has not received any FDA Form 483, notice of adverse finding, warning letter, untitled letter, or
other correspondence or notice from the FDA or any other Governmental Entity alleging or asserting noncompliance with any Applicable
Laws or any licenses, consents, certificates, approvals, clearances, authorizations, permits, orders and supplements or amendments thereto
required by any such Applicable Laws (“Authorizations”); (iii) possesses all material Authorizations and such
Authorizations are valid and in full force and effect and are not in material violation of any term of any such Authorizations; (iv)
has not received notice of any claim, action, suit, litigation, proceeding, hearing, enforcement, investigation, inquiry, arbitration
or other action from any Governmental Entity or third party alleging that any product operation or activity conducted by the Company
is in violation of any Applicable Laws or Authorizations and has no knowledge that any such Governmental Entity or third party is considering
any such claim, litigation, arbitration, action, suit, investigation, proceeding, hearing, enforcement or other action; (v) has not received
notice that any Governmental Entity has taken, is taking or intends to take action to limit, suspend, modify, or revoke any Authorizations
and has no knowledge that any such Governmental Entity is considering such action; (vi) has filed, obtained, maintained or submitted
all material reports, documents, forms, filings, notices, applications, records, claims, submissions and supplements or amendments as
required by any Applicable Laws or Authorizations and that all such reports, documents, forms, notices, applications, records, claims,
submissions, and supplements or amendments were complete and correct on the date filed (or were corrected or supplemented by a subsequent
submission); and (vii) has not, either voluntarily or involuntarily, initiated, conducted, or issued or caused to be initiated, conducted
or issued, any recall, market withdrawal or replacement, safety alert, post-sale warning, “dear doctor” letter, or other
notice or action relating to the alleged lack of safety or efficacy of any product or any alleged product defect or violation and, to
the Company’s knowledge, no third party has initiated, conducted or intends to initiate any such notice or action. The disclosure
in the Registration Statement, the Disclosure Package and the Prospectus concerning the effects of federal, state, provincial, local
and all foreign regulation in respect of the Company’s business are correct in all material respects.
2.41 Application
of Takeover Provisions. The Company and the Board have taken all necessary action, if any, in order to render inapplicable any control
share acquisition, business combination, poison pill (including any distribution under a rights agreement) or other similar anti-takeover
provision under the Company’s Articles (or similar constating documents) or the laws of its jurisdiction of incorporation that
is or could become applicable as a result of the Placement Agent and the Company fulfilling their obligations or exercising their rights
under this Agreement, the Placement Agent’s Warrant Agreement or the Pre-Funded Warrant Certificates.
2.42 [RESERVED].
2.43 Ineligible
Issuer. At the time of filing the Registration Statement and any post-effective amendment thereto, at the time of effectiveness of
the Registration Statement and any amendment thereto, at the earliest time thereafter that the Company or another offering participant
made a bona fide offer (within the meaning of Rule 164(h)(2) of the Securities Act Regulations) of the Securities and at the date hereof,
the Company was not and is not an “ineligible issuer,” as defined in Rule 405, without taking account of any determination
by the Commission pursuant to Rule 405 that it is not necessary that the Company be considered an ineligible issuer.
2.44 Real
and Personal Property. Except as set forth in the Registration Statement, the Disclosure Package, and the Prospectus, the Company
and each of its Subsidiaries have good and marketable title in fee simple to, or have valid rights to lease or otherwise use, all items
of real or personal property which are material to the business of the Company and its Subsidiaries taken as a whole, in each case free
and clear of all liens, encumbrances, security interests, claims, and defects that do not, singly or in the aggregate, materially affect
the value of such property and do not interfere with the use made and proposed to be made of such property by the Company or any of the
Subsidiaries; and all of the leases and subleases material to the business of the Company and its Subsidiaries, considered as one enterprise,
and under which the Company or any of its Subsidiaries holds properties described in the Registration Statement, the Disclosure Package,
and the Prospectus, are in full force and effect, and neither the Company nor any Subsidiary has received any notice of any material
claim of any sort that has been asserted by anyone adverse to the rights of the Company or any Subsidiary under any of the leases or
subleases mentioned above, or affecting or questioning the rights of the Company or such Subsidiary to the continued possession of the
leased or subleased premises under any such lease or sublease.
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2.45 Contracts
Affecting Capital. There are no transactions, arrangements or other relationships between and/or among the Company, any of its affiliates
(as such term is defined in Rule 405 of the Securities Act Regulations) and any unconsolidated entity, including, but not limited to,
any structured finance, special purpose or limited purpose entity that could reasonably be expected to materially affect the Company’s
or any of its Subsidiaries’ liquidity or the availability of or requirements for their capital resources required to be described
or incorporated by reference in the Registration Statement, the Disclosure Package and the Prospectus which have not been described or
incorporated by reference as required.
2.46 Loans
to Directors or Officers. There are no outstanding loans, advances (except normal advances for business expenses in the ordinary
course of business) or guarantees or indebtedness by the Company or its Subsidiaries to or for the benefit of any of the officers or
directors of the Company, its Subsidiaries or any of their respective family members, except as disclosed in the Registration Statement,
the Disclosure Package and the Prospectus.
2.47 Emerging
Growth Company. Since the closing of its initial public offering on February 26, 2021 through the date hereof, the Company has been
and is an “emerging growth company,” as defined in Section 2(a) of the Securities Act (an “Emerging Growth Company”).
“Testing-the-Waters Communication” means any oral or written communication with potential investors undertaken in reliance
on Section 5(d) of the Securities Act.
2.48 Smaller
Reporting Company. As of the time of filing of the Registration Statement, the Company was, and currently is, a “smaller reporting
company,” as defined in Rule 12b-2 of the Exchange Act Regulations.
2.49 Industry
Data. The statistical and market-related data included in each of the Registration Statement, the Disclosure Package, and the Prospectus
are based on or derived from sources that the Company reasonably and in good faith believes are reliable and accurate or represent the
Company’s good faith estimates that are made on the basis of data derived from such sources.
2.50 Margin
Securities. The Company owns no “margin securities” as that term is defined in Regulation U of the Board of Governors
of the Federal Reserve System (the “Federal Reserve Board”), and none of the proceeds of Offering will be used, directly
or indirectly, for the purpose of purchasing or carrying any margin security, for the purpose of reducing or retiring any indebtedness
which was originally incurred to purchase or carry any margin security or for any other purpose which might cause any of the Common Shares
to be considered a “purpose credit” within the meanings of Regulation T, U, or X of the Federal Reserve Board.
2.51 Exchange
Act Reports. The Company has filed in a timely manner all reports required to be filed pursuant to Sections 13(a), 13(e), 14 and
15(d) of the Exchange Act during the preceding twelve (12) months (except to the extent that Section 15(d) requires reports to be filed
pursuant to Sections 13(d) and 13(g) of the Exchange Act, which shall be governed by the next clause of this sentence); and the Company
has filed in a timely manner all reports required to be filed pursuant to Sections 13(d) and 13(g) of the Exchange Act since February
23, 2021, except where the failure to timely file could not reasonably be expected, individually or in the aggregate, to have a Material
Adverse Change.
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2.52 Minute
Books. The minute books of the Company and each Subsidiary have been made available to the Placement Agent and Placement Agent Counsel,
and such books (i) contain a complete summary of all meetings and actions of the Board (including each Board committee) and shareholders
of the Company (or analogous governing bodies and interest holders, as applicable), and each of its Subsidiaries since the time of its
respective incorporation or organization through the date of the latest meeting and action, and (ii) accurately in all material respects
reflect all transactions referred to in such minutes. There are no material transactions, agreements, dispositions, or other actions
of the Company and each Subsidiary that are not properly approved and/or accurately and fairly recorded in the minute books of the Company
or its Subsidiary, as applicable.
2.53 Environmental
Laws.
2.53.1. Compliance.
The Company and its Subsidiaries are in compliance with all federal, state, provincial and local laws and regulations relating to the
use, treatment, storage and disposal of hazardous or toxic substances or waste and protection of health and safety or the environment
which are applicable to their businesses (“Environmental Laws”).
2.53.2. Permits.
The Company has all permits, authorizations and approvals required under any applicable Environmental Laws and is in compliance with
their requirements.
2.53.3. Hazardous
Substances. There has been no storage, generation, transportation, handling, treatment, disposal, discharge, emission or other release
of any kind of toxic or other wastes or other hazardous substances by, due to, or caused by the Company or any of its Subsidiaries (or,
to the Company’s knowledge, any other entity for whose acts or omissions the Company or any of its Subsidiaries is or may otherwise
be liable) upon any of the property now or previously owned or leased by the Company or any of its Subsidiaries, or upon any other property,
in violation of any law, statute, ordinance, rule, regulation, order, judgment, decree or permit or which would, under any law, statute,
ordinance, rule (including rule of common law), regulation, order, judgment, decree or permit, give rise to any liability, except for
any violation or liability which would not have, singularly or in the aggregate with all such violations and liabilities, a Material
Adverse Effect; and there has been no disposal, discharge, emission or other release of any kind in violation of Environmental Laws onto
such property or into the environment surrounding such property of any toxic or other wastes or other hazardous substances with respect
to which the Company has knowledge.
2.53.4. No
Pending or Threatened Proceedings. There are no pending or, to the knowledge of the Company, threatened administrative, regulatory
or judicial actions, suits, demands, demand letters, claims, liens, notices of non-compliance or violation, investigation or proceedings
relating to any Environmental Laws against the Company.
2.53.5. No
Basis for Action. There are no events or circumstances, to the knowledge of the Company, that would reasonably be expected to form
the basis of an order for clean-up or remediation, or an action, suit or proceeding by any private party or Governmental Entity or against
or affecting the Company relating to any Environmental Laws.
2.53.6. Periodic
Review. In the ordinary course of business, the Company and its Subsidiaries conduct periodic reviews of the effect of Environmental
Laws on their business and assets, in the course of which they identify and evaluate associated costs and liabilities (including, without
limitation, any capital or operating expenditures required for clean-up, closure of properties or compliance with Environmental Laws
or governmental permits issued thereunder, any related constraints on operating activities and any potential liabilities to third parties).
On the basis of such reviews, the Company and its Subsidiaries have reasonably concluded that such associated costs and liabilities would
not have, singularly or in the aggregate, a Material Adverse Effect.
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2.54 Compliance
with FTC, U.S. Department of Health and Human Services. There is no complaint to or audit, proceeding, investigation (formal or informal)
or claim currently pending against the Company or its Subsidiaries, or to the knowledge of the Company, any of its customers (specific
to the customer’s use of the products or services of the Company) by the Federal Trade Commission, the U.S. Department of Health
and Human Services and any office contained therein (“HHS”), or any similar authority in any jurisdiction other than
the United States or any other Governmental Entity, or by any person in respect of the collection, use or disclosure of Personal Data
by the Company or its Subsidiaries, and, to the knowledge of the Company, no such complaint, audit, proceeding, investigation or claim
is threatened.
2.55 FDA,
Health Canada and Other Regulatory Authorities.
2.55.1. The
Company holds all licenses, certificates, approvals and permits from all United States federal and state and Canadian federal and provincial,
foreign and other regulatory authorities, including but not limited to the United States Food and Drug Administration (the “FDA”),
and Health Canada (“HC”), and any foreign regulatory authorities performing functions similar to those performed by the FDA,
and HC that are material to the conduct of the business of the Company or its Subsidiaries as such business is now conducted as described
in the Registration Statement, the Disclosure Package and the Prospectus, all of which are valid and in full force and effect and there
is no proceeding pending or, to the knowledge of the Company, threatened which may cause any such license, certificate, approval or permit
to be withdrawn, cancelled, suspended or not renewed.
2.55.2. Nothing
has come to the attention of the Company that has caused the Company to believe that the completed studies, tests, preclinical studies
and clinical trials conducted by or on behalf of the Company and its Subsidiaries that are described in the Registration Statement, the
Disclosure Package and the Prospectus were not conducted, in all material respects, in accordance with experimental protocols, procedures
and controls pursuant to, where applicable, accepted professional and scientific standards for products or product candidates comparable
to those being developed by the Company; or that the drug substances used in the clinical trials have not been manufactured, in all material
respects, under “current good manufacturing practices”, when required, in the United States, Canada and other jurisdictions
in which such clinical trials have been and are being conducted.
2.55.3. No
filing or submission to the FDA, HC, or any other regulatory body, that was or is intended to be the basis for any approval of the Company’s
products or product candidates, to the knowledge of the Company, contains any material omission or material false information.
2.55.4. The
Company is not in violation in any material respect, of any material law, order, rule, regulation, writ, injunction or decree of any
court or governmental agency or body, applicable to the investigation of new drugs in humans and animals, including, but not limited
to, those promulgated by the FDA, or HC.
2.56 Export
and Import Laws. The Company and, to the Company’s knowledge, each of its affiliates, and any director, officer, agent or employee
of, or other person associated with or acting on behalf of the Company, has acted at all times in compliance in all material respects
with applicable Export and Import Laws (as defined below) and there are no claims, complaints, charges, investigations or proceedings
pending or expected or, to the knowledge of the Company, threatened between the Company or any of its Subsidiaries and any Governmental
Entity under any Export or Import Laws. The term “Export and Import Laws” means the Arms Export Control Act, the International
Traffic in Arms Regulations, the Export Administration Act of 1979, as amended, the Export Administration Regulations, and all other
laws and regulations of the United States government regulating the provision of services to non-U.S. parties or the export and import
of articles or information from and to the United States of America, and all similar laws and regulations of any foreign government regulating
the provision of services to parties not of the foreign country or the export and import of articles and information from and to the
foreign country to parties not of the foreign country.
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2.57 Integration.
Neither the Company, nor any of its affiliates, nor any person acting on its or their behalf has, directly or indirectly, made any offers
or sales of any security or solicited any offers to buy any security, under circumstances that would cause the Offering to be integrated
with prior offerings by the Company for purposes of the Securities Act that would require the registration of any such securities under
the Securities Act.
2.58 No
Stabilization. Neither the Company nor, to its knowledge, any of its employees, directors, or shareholders (without the consent of
the Placement Agent) has taken or shall take, directly or indirectly, any action designed to or that has constituted or that might reasonably
be expected to cause or result in, under Regulation M of the Exchange Act, or otherwise, stabilization, or manipulation of the price
of any security of the Company to facilitate the sale or resale of the Securities.
2.59 No
Undisclosed Relationships. No relationship, direct or indirect, exists between or among the Company or any of its Subsidiaries, on
the one hand, and the directors, officers, shareholders, customers, suppliers or other affiliates of the Company or any of its Subsidiaries,
on the other, that is required by the Securities Act to be described in each of the Registration Statement and the Prospectus and that
is not so described in such documents and in the Disclosure Package.
2.60 Confidentiality
and Non-Competition. To the Company’s knowledge, no director, officer, key employee, or consultant of the Company is subject
to any confidentiality, non-disclosure, non-competition agreement, or non-solicitation agreement with any employer or prior employer
that could reasonably be expected to materially affect his ability to be and act in his respective capacity of the Company or be expected
to result in a Material Adverse Change.
2.61 Testing-the-Waters
Communications. The Company has not (i) alone engaged in any Testing-the-Waters Communications, other than Testing-the-Waters Communications
with the written consent of the Placement Agent and with entities that are qualified institutional buyers within the meaning of Rule
144A under the Securities Act or institutions that are accredited investors within the meaning of Rule 501 under the Securities Act and
(ii) authorized anyone other than the Placement Agent to engage in Testing- the-Waters Communications. The Company confirms that the
Placement Agent has been authorized to act on its behalf in undertaking Testing-the-Waters Communications. The Company has not distributed
any Written Testing-the-Waters Communications other than those listed on Schedule 2-B hereto. “Written Testing-the-Waters
Communication” means any Testing-the-Waters Communication that is a written communication within the meaning of Rule 405 under
the Securities Act.
2.62 Electronic
Road Show. The Company has made available a Bona Fide Electronic Road Show in compliance with Rule 433(d)(8)(ii) of the Securities
Act Regulations such that no filing of any “road show” (as defined in Rule 433(h) of the Securities Act Regulations) is required
in connection with the Offering.
2.63 Corporate
Records. The corporate records of the Company have been made available to the Placement Agent and Placement Agent Counsel, and such
corporate records accurately in all material respects reflect all transactions referred to in such records. There are no material transactions,
agreements, dispositions or other actions of the Company that are not properly approved and/or accurately and fairly recorded in the
corporate records of the Company, as applicable.
2.64 Canadian
Securities Laws.
2.64.1. The
Company is a reporting issuer in the Provinces of British Columbia, Alberta, Manitoba, New Brunswick, Newfoundland and Labrador, Nova
Scotia, Ontario, Prince Edward Island, Québec, Saskatchewan, and the Territories of the Yukon, Northwest Territories and Nunavut,
is not in default of any material requirement of the Canadian Securities Laws of the Province of British Columbia and Alberta and is
not included on a list of defaulting reporting issuers maintained by the securities regulators of such jurisdictions.
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2.64.2. The
Company is in compliance in all material respects with its timely and continuous disclosure obligations under all applicable Canadian
Securities Laws and the Company is not in default of its filings under, nor has it failed to file or publish any document required to
be filed or published under all applicable Canadian Securities Laws and, without limiting the generality of the foregoing, there has
not occurred any Material Adverse Change since the respective dates as of which information is given in the Canadian Public Disclosure
Documents which has not been publicly disclosed on a non-confidential basis and the Company has not filed any confidential material change
reports since the date of such statements which remain confidential as at the date hereof.
2.64.3. The
Canadian Public Disclosure Documents contain no untrue statement of a material fact as at the dates thereof nor do they omit to state
a material fact which, at the date thereof, was required to have been stated or was necessary to prevent a statement that was made from
being false or misleading in the circumstances in which it was made and were prepared in accordance with and comply with Canadian Securities
Laws.
2.64.4. There
are no reports or information that, in accordance with the requirements of the Canadian Securities Regulators or applicable Canadian
Securities Laws, must be made publicly available in connection with the Offering that have not been made publicly available, as required.
There are no documents required to be filed with the Canadian Securities Regulators as of the date hereof in connection with the Offering
that have not been filed as required, other than the filing of the Registration Statement and any post-closing filings required to be
made by the Company pursuant to the Canadian Securities Laws.
3. Covenants
of the Company. The Company covenants and agrees as follows:
3.1 Amendments
to Registration Statement. The Company shall deliver to the Placement Agent, prior to filing, any amendment or supplement to the
Registration Statement, Disclosure Package, or Prospectus proposed to be filed after the date hereof and not file any such amendment
or supplement to which the Placement Agent shall reasonably object in writing.
3.2 Federal
Securities Laws.
3.2.1. Compliance.
The Company, subject to Section 3.2.2, shall comply with the requirements of Rule 424(b) and Rule 430B of the Securities Act Regulations,
and will notify the Placement Agent promptly, and confirm the notice in writing, (i) when any post-effective amendment to the Registration
Statement shall become effective or any amendment or supplement to any Preliminary Prospectus, the Disclosure Package or the Prospectus
shall have been filed; (ii) of the receipt of any comments from the Commission; (iii) of any request by the Commission for any amendment
to the Registration Statement or any amendment or supplement to any Preliminary Prospectus, the Disclosure Package or the Prospectus
or for additional information; (iv) of the issuance by the Commission of any stop order suspending the effectiveness of the Registration
Statement or any post-effective amendment or of any order preventing or suspending the use of any Preliminary Prospectus, the Disclosure
Package or the Prospectus, or of the suspension of the qualification of the Securities and Placement Agent’s Securities for offering
or sale in any jurisdiction, or of the initiation or threatening of any proceedings for any of such purposes or of any examination pursuant
to Section 8(d) or 8(e) of the Securities Act concerning the Registration Statement; and (v) if the Company becomes the subject of a
proceeding under Section 8A of the Securities Act in connection with the Offering of the Securities and Placement Agent’s Securities.
The Company shall effect all filings required under Rule 424(b) of the Securities Act Regulations, in the manner and within the time
period required by Rule 424(b) (without reliance on Rule 424(b)(8)), and shall take such steps as it deems necessary to ascertain promptly
whether the form of prospectus transmitted for filing under Rule 424(b) was received for filing by the Commission and, in the event that
it was not, it will promptly file such prospectus. The Company shall comply with the requirements of Section 4 of BC Instrument 72-503
Distribution of Securities Outside British Columbia with respect to the Offering made either to (i) a purchaser that is not resident
in Canada or (ii) on or through the facilities of an exchange or market outside Canada and the Company or Placement Agent have no reason
to believe that the purchaser is resident in Canada. The Placement Agent and the Company agree to conduct the Offering in such a manner
so as not to require registration thereof or the filing of a registration statement or a prospectus or similar document in any jurisdiction,
other than the United States of America. To the extent that the Company and the Placement Agent agree in writing that the Securities
will be offered to residents of Canada on a private placement basis exempt from the prospectus requirements of Canadian Securities Laws,
the Company shall comply with the requirements relating to the prospectus exemptions under the Canadian Securities Laws with respect
to the Offering that is made to a purchaser that is resident in Canada and the Placement Agent shall comply with all reasonable requests
in connection with such offering made by the Company and in such written agreement. The Company shall use its best efforts to prevent
the issuance of any stop order, prevention or suspension and, if any such order is issued, to obtain the lifting thereof at the earliest
possible moment.
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3.2.2. Continued
Compliance. The Company shall comply with the Securities Act, the Securities Act Regulations, the Exchange Act, the Exchange Act
Regulations, and the Canadian Securities Laws, so as to permit the completion of the distribution of the Securities as contemplated in
this Agreement, the Pre-Funded Warrant Certificates and in the Registration Statement, the Disclosure Package, and the Prospectus. If
at any time when a prospectus relating to the Securities is (or, but for the exception afforded by Rule 172 of the Securities Act Regulations
(“Rule 172”), would be) required by the Securities Act to be delivered in connection with sales of the Securities,
any event shall occur or condition shall exist as a result of which it is necessary, in the opinion of counsel for the Placement Agent
or for the Company, to (i) amend the Registration Statement in order that the Registration Statement will not include an untrue statement
of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading;
(ii) amend or supplement the Disclosure Package or the Prospectus in order that the Disclosure Package or the Prospectus, as the case
may be, will not include any untrue statement of a material fact or omit to state a material fact necessary in order to make the statements
therein not misleading in light of the circumstances existing at the time it is delivered to a purchaser, or (iii) amend the Registration
Statement or amend or supplement the Disclosure Package or the Prospectus, as the case may be, in order to comply with the requirements
of the Securities Act or the Securities Act Regulations, the Company will promptly (A) give the Placement Agent notice of such event;
(B) prepare any amendment or supplement as may be necessary to correct such statement or omission or to make the Registration Statement,
the Disclosure Package, or the Prospectus comply with such requirements and, a reasonable amount of time prior to any proposed filing
or use, furnish the Placement Agent with copies of any such amendment or supplement; and (C) file with the Commission any such amendment
or supplement; provided, however, that the Company shall not file or use any such amendment or supplement to which the
Placement Agent or counsel for the Placement Agent shall reasonably object. The Company will furnish to the Placement Agent such number
of copies of such amendment or supplement as the Placement Agent may reasonably request. The Company has given the Placement Agent notice
of any filings made pursuant to the Exchange Act or the Exchange Act Regulations within forty-eight (48) hours prior to the Applicable
Time. The Company shall give the Placement Agent notice of its intention to make any such filing from the Applicable Time until the Closing
Date and will furnish the Placement Agent with copies of the related document(s) a reasonable amount of time prior to such proposed filing,
as the case may be, and will not file or use any such document to which the Placement Agent or counsel for the Placement Agent shall
reasonably object.
3.2.3. Exchange
Act Registration. Until the later of (i) three (3) years after the date of this Agreement and (ii) the expiration or exercise of
all of the Pre-Funded Warrants, the Company shall use its best efforts to maintain the registration of the Common Shares under the Exchange
Act. During such period, the Company shall not deregister the Common Shares under the Exchange Act without the prior written consent
of the Placement Agent.
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3.2.4. Free
Writing Prospectuses. The Company agrees that, unless it obtains the prior written consent of the Placement Agent, it shall not make
any offer relating to the Securities that would constitute an Issuer Free Writing Prospectus or that would otherwise constitute a “free
writing prospectus,” or a portion thereof, required to be filed by the Company with the Commission or retained by the Company under
Rule 433; provided, however, that the Placement Agent shall be deemed to have consented to each Issuer General Use Free
Writing Prospectus hereto and any “road show that is a written communication” within the meaning of Rule 433(d)(8)(i) that
has been reviewed and approved by the Placement Agent. The Company represents that it has treated or agrees that it will treat each such
free writing prospectus consented to, or deemed consented to, by the Placement Agent as an “issuer free writing prospectus,”
as defined in Rule 433, and that it has complied and will comply with the applicable requirements of Rule 433 with respect thereto, including
timely filing with the Commission where required, legending and record keeping. If at any time following issuance of an Issuer Free Writing
Prospectus there occurred or occurs an event or development as a result of which such Issuer Free Writing Prospectus conflicted or would
conflict with the information contained in the Registration Statement or included or would include an untrue statement of a material
fact or omitted or would omit to state a material fact necessary in order to make the statements therein, in light of the circumstances
existing at that subsequent time, not misleading, the Company will promptly notify the Placement Agent and will promptly amend or supplement,
at its own expense, such Issuer Free Writing Prospectus to eliminate or correct such conflict, untrue statement or omission.
3.2.5. Testing-the-Waters
Communications. If at any time following the distribution of any Written Testing-the-Waters Communication there occurred or occurs
an event or development as a result of which such Written Testing-the-Waters Communication included or would include an untrue statement
of a material fact or omitted or would omit to state a material fact necessary in order to make the statements therein, in light of the
circumstances existing at that subsequent time, not misleading, the Company shall promptly notify the Placement Agent and shall promptly
amend or supplement, at its own expense, such Written Testing-the-Waters Communication to eliminate or correct such untrue statement
or omission.
3.3 Delivery
to the Placement Agent of Registration Statements. The Company has delivered or made available or shall deliver or make available
to the Placement Agent and counsel for the Placement Agent, without charge, signed copies of the Registration Statement as originally
filed and each amendment thereto (including exhibits filed therewith or incorporated by reference therein and documents incorporated
or deemed to be incorporated by reference therein) and signed copies of all consents and certificates of experts, and will also deliver
to the Placement Agent, without charge, a conformed copy of the Registration Statement as originally filed and each amendment thereto
(without exhibits) for the Placement Agent. The copies of the Registration Statement and each amendment thereto furnished to the Placement
Agent will be identical to the electronically transmitted copies thereof filed with the Commission pursuant to EDGAR, except to the extent
permitted by Regulation S-T.
3.4 Delivery
to the Placement Agent of Prospectuses. The Company has delivered or made available or will deliver or make available to each Placement
Agent, without charge, as many copies of each Preliminary Prospectus as such Placement Agent reasonably requested, and the Company hereby
consents to the use of such copies for purposes permitted by the Securities Act. The Company will furnish to each Placement Agent, without
charge, during the period when a prospectus relating to the Securities is (or, but for the exception afforded by Rule 172, would be)
required to be delivered under the Securities Act, such number of copies of the Prospectus (as amended or supplemented) as such Placement
Agent may reasonably request. The Prospectus and any amendments or supplements thereto furnished to the Placement Agent will be identical
to the electronically transmitted copies thereof filed with the Commission pursuant to EDGAR, except to the extent permitted by Regulation
S-T.
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3.5 Events
Requiring Notice to the Placement Agent. The Company shall use its best efforts to cause the Registration Statement to remain effective
with a current prospectus related to the Registration Statement, promptly amending the prospectus that is part of the Registration Statement
as necessary to comply with the requirements of the Securities Act of 1933, as amended, as well as any applicable rules and regulations
promulgated by the Commission until the later of (i) at least nine (9) months after the Applicable Time and (ii) through and including
the expiration date of the Pre-Funded Warrants (or the date that all of the Pre-Funded Warrants have been exercised, if earlier), and
shall notify the Placement Agent immediately and confirm the notice in writing: (i) of the effectiveness of the Registration Statement
and any amendment thereto; (ii) of the issuance by the Commission of any stop order or of the initiation, or the threatening, of any
proceeding for that purpose; (iii) of the issuance by any state securities commission of any proceedings for the suspension of the qualification
of the Securities for offering or sale in any jurisdiction or of the initiation, or the threatening, of any proceeding for that purpose;
(iv) of the issuance by any Canadian Securities Regulator of a Cease Trade Order; (v) of the mailing and delivery to the Commission for
filing of any amendment or supplement to the Registration Statement or Prospectus; (vi) of the receipt of any comments or request for
any additional information from the Commission; and (vii) of the happening of any event during the period described in this Section
3.5 that, in the judgment of the Company, makes any statement of a material fact made in the Registration Statement, the Disclosure
Package or the Prospectus untrue or that requires the making of any changes in (a) the Registration Statement in order to make the statements
therein not misleading, or (b) in the Disclosure Package or the Prospectus in order to make the statements therein, in light of the circumstances
under which they were made, not misleading. If the Commission or any state securities commission shall enter a stop order or suspend
such qualification at any time, the Company shall make every reasonable effort to obtain promptly the lifting of such order. If any Canadian
Securities Regulator shall enter an order ceasing or suspending trading in any securities of the Company at any time, the Company shall
make every reasonable effort to obtain promptly the lifting of such order.
3.6 Review
of Financial Statements. For a period of five (5) years after the date of this Agreement, the Company, at its expense, shall cause
its regularly engaged independent registered public accounting firm to review (but not audit) the Company’s financial statements
for each of the three fiscal quarters immediately preceding the announcement of any quarterly financial information.
3.7 Listing.
The Company shall use its best efforts to maintain the listing of the Common Shares (including the Securities sold pursuant to this Offering)
on the Exchange and the TSX, as applicable, until the later of (i) three (3) years from the date of this Agreement and (ii) the date
that all of the Pre-Funded Warrants have been exercised or otherwise expired provided that this covenant shall not prevent the Company
from completing any transaction which would result in the Common Shares ceasing to be listed so long as the holders of Common Shares
receive securities of an entity which is listed on a Trading Market or cash, or the holders of Common Shares have approved the transaction
in accordance with the requirements of applicable corporate and securities laws and the rules and policies of the Exchange and TSX.
“Trading
Market” means any of the following markets or exchanges on which the Common Shares are listed or quoted for trading on the
date in question: the NYSE MKT, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, or the New York
Stock Exchange (or any successors to any of the foregoing).
3.8 Exchange
Submission of Listing of Additional Shares. The Company agrees to make a timely submission of the Listing of Additional Shares Notification
Form with the Exchange with respect to the Offering.
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3.9 [RESERVED].
3.10 Reports
to the Placement Agent.
3.10.1. Periodic
Reports, etc. For a period of three (3) years after the date of this Agreement or the expiration or exercise of all of the Pre-Funded
Warrants, whichever is later, the Company shall furnish or make available to the Placement Agent copies of such financial statements
and other periodic and special reports as the Company from time to time furnishes generally to holders of any class of its securities
and also promptly furnish to the Placement Agent: (i) a copy of each periodic report the Company shall be required to file with the Commission
under the Exchange Act and the Exchange Act Regulations; (ii) a copy of every press release and every news item and article with respect
to the Company or its affairs which was released by the Company; (iii) a copy of each Form 8-K prepared and filed by the Company; (iv)
five (5) copies of each registration statement filed by the Company under the Securities Act; (v) a copy of each report or other communication
furnished to shareholders; and (vi) such additional documents and information with respect to the Company and the affairs of any future
subsidiaries of the Company as the Placement Agent may from time to time reasonably request; provided, however, the Placement
Agent shall sign, if requested by the Company, a Regulation FD compliant confidentiality agreement which is reasonably acceptable to
the Placement Agent and Placement Agent Counsel in connection with the Placement Agent’s receipt of such information. Documents
filed with the Commission pursuant to its EDGAR system shall be deemed to have been delivered to the Placement Agent pursuant to this
Section 3.10.1. “EDGAR” means the Electronic Data Gathering, Analysis, and Retrieval system.
3.10.2. Transfer
Agent; Transfer Sheets. Until the later of (i) three (3) years after the date of this Agreement and (ii) the expiration or exercise
of all of the Pre-Funded Warrants, the Company shall retain a transfer agent and registrar acceptable to the Placement Agent (the “Transfer
Agent”) and shall furnish to the Placement Agent at the Company’s sole cost and expense such transfer sheets of the Company’s
securities as the Placement Agent may reasonably request, including the daily and monthly consolidated transfer sheets of the Transfer
Agent and DTC. Computershare Investor Services Inc. is acceptable to the Placement Agent to act as Transfer Agent for the Common Shares.
3.10.3. Trading
Reports. During such time as the Shares and the Common Shares underlying the Pre-Funded Warrants are listed on the Exchange, the
Company shall provide to the Placement Agent, at the Company’s expense, such reports published by Exchange relating to price trading
of any of the Shares and the Common Shares underlying the Pre-Funded Warrants as the Placement Agent shall reasonably request.
3.11 Payment
of Expenses. The Company hereby agrees to pay on the Closing Date to the extent not paid at the Closing Date, all expenses incident
to the performance of the obligations of the Company under this Agreement, including, but not limited to: (a) all filing fees and communication
expenses relating to the registration of the Securities to be issued and sold in the Offering with the Commission; (b) all filing fees
associated with the review of the Offering by FINRA, the Exchange and TSX; (c) all fees and expenses relating to the listing of such
Securities on the Exchange, the TSX and such other stock exchanges as the Company and the Placement Agent together determine, including
any fees charged by the DTC for new securities; (d) all fees, expenses and disbursements relating to background checks of the Company’s
officers and directors in an amount not to exceed $15,000 in the aggregate; (e) all fees, expenses and disbursements relating to the
registration or qualification of the Securities under the “blue sky” securities laws of such states and other jurisdictions
as the Placement Agent may reasonably designate (including, without limitation, all filing and registration fees); (f) all fees, expenses,
and disbursements relating to the registration, qualification, or exemption of the Securities under the securities laws of such foreign
jurisdictions as the Placement Agent may reasonably designate; (g) the costs of all mailing and printing of the offering documents (including,
without limitation, the Placement Agency Agreement, any blue sky surveys and, if appropriate, any agreement among placement agents, selected
dealers’ agreement, placement agents’ questionnaire and power of attorney), Registration Statements, Prospectuses, and all
amendments, supplements, and exhibits thereto and as many preliminary and final Prospectuses as the Placement Agent may reasonably deem
necessary; (h) the costs and expenses of a public relations firm, if applicable; (i) the costs of preparing, printing, and delivering
certificates representing the Securities; (j) fees and expenses of the Transfer Agent for the Securities; (k) stock transfer and/or stamp
taxes, if any, payable upon the transfer of securities from the Company to the Placement Agent; (l) the costs associated with post-Closing
advertising the Offering in the national editions of the Wall Street Journal and New York Times; (m) the costs associated with bound
volumes of the public offering materials as well as commemorative mementos and lucite tombstones, each of which the Company or its designee
will provide within a reasonable time after the Closing in such quantities as the Placement Agent may reasonably request, in an amount
not to exceed $3,000; (n) the fees and expenses of the Company’s accountants; (o) the fees and expenses of the Company’s
legal counsel and other agents; (p) fees and expenses of Placement Agent Counsel not to exceed $125,000; (q) the $29,500 cost associated
with the Placement Agent’s use of Ipreo’s book-building, prospectus tracking and compliance software for the Offering; (r)
[RESERVED]; (s) up to $10,000 of the Placement Agent’s actual accountable “road show” expenses; and (t) up to $15,000
of the Placement Agent’s market making and trading, and clearing firm settlement expenses for the Offering. The Placement Agent
may deduct from the net proceeds of the Offering payable to the Company on the Closing Date, the expenses set forth herein to be paid
by the Company to the Placement Agent provided, however, that in the event that the Offering is terminated, the Company
agrees to reimburse the Placement Agent, less any amounts previously advanced, pursuant to Section 8.3 hereof.
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3.12 Application
of Net Proceeds. The Company shall apply the net proceeds from the Offering received by it in a manner consistent with the application
thereof described under the caption “Use of Proceeds” in the Registration Statement, the Disclosure Package, and the Prospectus.
3.13 Delivery
of Earnings Statements to Security Holders. The Company shall make generally available to its security holders as soon as practicable,
but not later than the first day of the fifteenth (15th) full calendar month following the date of this Agreement, an earnings
statement (which need not be certified by independent registered public accounting firm unless required by the Securities Act or the
Securities Act Regulations, but which shall satisfy the provisions of Rule 158(a) under Section 11(a) of the Securities Act) covering
a period of at least twelve (12) consecutive months beginning after the date of this Agreement. For the avoidance of doubt, earnings
statements filed with the Commission pursuant to EDGAR shall be deemed to have been made available to the Company’s security holders
for purposes of this Section 3.13.
3.14 Stabilization.
Neither the Company nor, to its knowledge, any of its employees, directors, or shareholders (without the consent of the Placement Agent)
has taken or shall take, directly or indirectly, any action designed to or that has constituted or that might reasonably be expected
to cause or result in, under Regulation M of the Exchange Act, or otherwise, stabilization or manipulation of the price of any security
of the Company to facilitate the sale or resale of the Securities.
3.15 Internal
Controls. The Company shall maintain a system of internal accounting controls sufficient to provide reasonable assurances that: (i)
transactions are executed in accordance with management’s general or specific authorization; (ii) transactions are recorded
as necessary in order to permit preparation of financial statements in accordance with GAAP and to maintain accountability for assets;
(iii) access to assets is permitted only in accordance with management’s general or specific authorization; and (iv) the recorded
accountability for assets is compared with existing assets at reasonable intervals and appropriate action is taken with respect to any
differences.
3.16 Accountants.
As of the date of this Agreement, the Company shall continue to retain a nationally recognized independent registered public accounting
firm for a period of at least three (3) years after the date of this Agreement. The Placement Agent acknowledges that MNP LLP is acceptable
to the Placement Agent.
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3.17 FINRA.
The Company shall advise the Placement Agent (who shall make an appropriate filing with FINRA) if it is or becomes aware that (i) any
officer or director of the Company, (ii) to the Company’s knowledge, any beneficial owner of five percent (5%) or more of any class
of the Company’s securities, or (iii) any beneficial owner of the Company’s unregistered equity securities which were acquired
during the one hundred eighty (180) days immediately preceding the filing of the Registration Statement is or becomes an affiliate or
associated person of a FINRA member participating in the Offering (as determined in accordance with the rules and regulations of FINRA).
3.18 No
Fiduciary Duties. The Company acknowledges and agrees that the Placement Agent’s responsibility to the Company is solely contractual
in nature and that none of the Placement Agent or their affiliates or any selling agent shall be deemed to be acting in a fiduciary capacity,
or otherwise owes any fiduciary duty to the Company or any of its affiliates in connection with the Offering and the other transactions
contemplated by this Agreement. Notwithstanding anything in this Agreement to the contrary, the Company acknowledges that the Placement
Agent may have financial interests in the success of the Offering that are not limited to the Cash Fee and the Placement Agent has no
obligation to disclose, or account to the Company for, any of such additional financial interests. The Company hereby waives and releases,
to the fullest extent permitted by law, any claims that the Company may have against the Placement Agent with respect to any breach or
alleged breach of fiduciary duty.
3.19 [RESERVED].
3.20 Company
Lock-Up Agreements. The Company, on behalf of itself and any successor entity, agrees that, without the prior written consent of
the Placement Agent, it will not, for a period of three (3) months from the Closing (the “Lock-Up Period”), (i) offer,
pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right
or warrant to purchase, lend, or otherwise transfer or dispose of, directly or indirectly, any shares of capital stock of the Company
or any securities convertible into or exercisable or exchangeable for shares of capital stock of the Company; (ii) file or cause to be
filed any registration statement with the Commission relating to the offering of any shares of capital stock of the Company or any securities
convertible into or exercisable or exchangeable for shares of capital stock of the Company; (iii) complete any offering of debt securities
of the Company, other than entering into a line of credit with a traditional bank or (iv) enter into any swap or other arrangement that
transfers to another, in whole or in part, any of the economic consequences of ownership of capital stock of the Company, whether any
such transaction described in clause (i), (ii), (iii) or (iv) above is to be settled by delivery of shares of capital stock of the Company
or such other securities, in cash or otherwise.
The
restrictions contained in Section 3.20 shall not apply to (i) registration statements on Form S-8, (ii) the Securities and the
Placement Agent’s Securities to be sold hereunder, (iii) the issuance by the Company of Common Shares upon the exercise of a stock
option or warrant or the conversion of a security outstanding on the date hereof, which is disclosed in the Registration Statement, Disclosure
Package and Prospectus, provided that such options, warrants, and securities have not been amended since the date of this Agreement to
increase the number of such securities or to decrease the exercise price, exchange price or conversion price of such securities or to
extend the term of such securities, (iv) the grant by the Company of stock options or other equity-based awards, or the issuance of Common
Shares under any equity compensation plan of the Company, or (v) the issuance by the Company of Common Shares or other securities of
the Company in connection with strategic transactions not for capital raising purposes, provided that such securities are issued as “restricted
securities” (as defined in Rule 144), provided further that in each of (iv) and (v) above, the underlying shares shall be restricted
from sale during the entire Lock-Up Period.
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3.21 Release
of D&O Lock-up Period. If the Placement Agent, in its sole discretion, agrees to release or waive the restrictions set forth
in the Lock-Up Agreements described in Section 2.27 hereof for an officer or director of the Company and provide the Company with
notice of the impending release or waiver at least three (3) Business Days before the effective date of the release or waiver, the Company
agrees to announce the impending release or waiver by a press release substantially in the form of Exhibit B hereto through a
major news service at least two (2) Business Days before the effective date of the release or waiver.
3.22 Blue
Sky Qualifications. The Company shall use its best efforts, in cooperation with the Placement Agent, if necessary, to qualify the
Securities for offering and sale under the applicable securities laws of such states and other jurisdictions (domestic or foreign) as
the Placement Agent may designate and to maintain such qualifications in effect so long as required to complete the distribution of the
Securities; provided, however, that the Company shall not be obligated to file any general consent to service of process
or to qualify as a foreign corporation or as a dealer in securities in any jurisdiction in which it is not so qualified or to subject
itself to taxation in respect of doing business in any jurisdiction in which it is not otherwise so subject.
3.23 Reporting
Requirements. The Company, during the period when a prospectus relating to the Securities is (or, but for the exception afforded
by Rule 172, would be) required to be delivered under the Securities Act, will file all documents required to be filed with the Commission
pursuant to the Exchange Act within the time periods required by the Exchange Act and Exchange Act Regulations. Additionally, the Company
shall report the use of proceeds from the issuance of the Securities as may be required under Rule 463 under the Securities Act Regulations.
3.24 Press
Releases. Prior to the Closing Date, the Company shall not issue any press release or other communication directly or indirectly
or hold any press conference with respect to the Company, its condition, financial, or otherwise, or earnings, business affairs, or business
prospects (except for routine oral marketing communications in the ordinary course of business and consistent with the past practices
of the Company and of which the Placement Agent is notified), without the prior written consent of the Placement Agent, which consent
shall not be unreasonably withheld, unless in the judgment of the Company and its counsel, and after notification to the Placement Agent,
such press release or communication is required by law.
3.25 Emerging
Growth Company Status. The Company shall promptly notify the Placement Agent if the Company ceases to be an Emerging Growth Company
at any time prior to the later of (i) completion of the distribution of the Securities within the meaning of the Securities Act and (ii)
fifteen (15) days following the completion of the Lock-Up Period.
3.26 [RESERVED].
3.27 Sarbanes-Oxley.
Except as disclosed in the Registration Statement, the Disclosure Package, and the Prospectus, the Company shall at all times comply
with all applicable provisions of the Sarbanes-Oxley Act in effect from time to time.
3.28 Reservation
of Common Shares. As of the date hereof, the Company has irrevocably reserved, and the Company shall continue to reserve and keep
available at all times, free of pre-emptive rights, a sufficient number of Common Shares for the purpose of enabling the Company to issue
the Warrant Shares and the Placement Agent’s Warrant Shares.
4. Conditions
of Placement Agent’s Obligations. The obligations of the Placement Agent as provided herein, shall be subject to (i) the continuing
accuracy of the representations and warranties of the Company as of the date hereof and as of the Closing Date, (ii) the accuracy of
the statements of officers of the Company made pursuant to the provisions hereof; (iii) the performance by the Company of its obligations
hereunder; and (iv) the following conditions:
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4.1 Regulatory
Matters.
4.1.1. Commission
Actions; Required Filings. On the Closing Date, no stop order suspending the effectiveness of the Registration Statement or any post-effective
amendment thereto shall have been issued under the Securities Act, no order preventing or suspending the use of any Preliminary Prospectus
or the Prospectus shall have been issued, and no proceedings for any of those purposes have been instituted or are pending or, to the
Company’s knowledge, contemplated by the Commission. The Company has complied with each request (if any) from the Commission for
additional information. A prospectus containing the Rule 430B Information shall have been filed with the Commission in the manner and
within the time frame required by Rule 424(b) under the Securities Act Regulations (without reliance on Rule 424(b)(8)) or a post-effective
amendment providing such information shall have been filed with, and declared effective by, the Commission in accordance with the requirements
of Rule 430B under the Securities Act Regulations.
4.1.2. No
Cease Trade Order. On the Closing Date, no Cease Trade Order shall have been issued by any Canadian Securities Regulator and no proceedings
for such purpose, to the knowledge of the Company, will be pending or threatened.
4.1.3. No
Objection. FINRA has not raised any objection with respect to the fairness and reasonableness of the Placement Agent’s compensation
relating to the offering of the Securities.
4.1.4. Exchange
Stock Market Clearance. On the Closing Date (i) the Company shall have filed a Listing of Additional Shares Notification Form with
the Exchange with respect to the Offering of the Securities.
4.1.5. TSX
Acceptance. On the Closing Date, the TSX shall have conditionally accepted the Offering and the listing of the Common Shares, Warrant
Shares and Placement Agent’s Warrant Shares, subject only to the satisfaction of the customary listing conditions.
4.2 Company
Counsel Matters.
4.2.1. Closing
Date Opinion of U.S. Counsel. On the Closing Date, the Placement Agent shall have received the favorable opinion of Sichenzia Ross
Ference Carmel LLP, U.S. counsel to the Company, and a written statement providing certain “10b-5” negative assurances, dated
the Closing Date and addressed to the Placement Agent, substantially in the form of Exhibit C-I attached hereto or as otherwise
agreed by the Placement Agent.
4.2.2. Closing
Date Opinion of Canadian Counsel. On the Closing Date, the Placement Agent shall have received the favorable opinion of Bennett Jones
LLP, Canadian legal counsel to the Company and addressed to the Placement Agent, substantially in the form of Exhibit C-II attached
hereto.
4.2.3. Opinion
of Special Intellectual Property Counsel for the Company. On the Closing Date, the Placement Agent shall have received the opinion
of Kilpatrick Townsend & Stockton LLP, special intellectual property counsel for the Company, and a written statement providing certain
“10b-5” negative assurances, dated the Closing Date and addressed to the Placement Agent, substantially in the form of Exhibit
C-III attached hereto.
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4.2.4. Reliance.
In rendering such opinions, such counsel may rely: (i) as to matters involving the application of laws other than the laws of the United
States and Canada and jurisdictions in which they are admitted, as applicable, to the extent such counsel deems proper and to the extent
specified in such opinion, if at all, upon an opinion or opinions (in form and substance reasonably satisfactory to the Placement Agent)
of other counsel reasonably acceptable to the Placement Agent, familiar with the applicable laws, and alternatively, such opinion of
other counsel may be addressed directly to the Placement Agent; and (ii) as to matters of fact, to the extent they deem proper, on certificates
or other written statements of officers of the Company and officers of departments of various jurisdictions having custody of documents
respecting the corporate existence or good standing of the Company, provided that copies of any such statements or certificates shall
be delivered to Placement Agent Counsel if requested. The opinions of each counsel listed in Sections 4.2.1, 4.2.2 and 4.2.3 and any
opinions relied upon by any such counsel shall include a statement to the effect that they may be relied upon by Placement Agent Counsel
in such counsel’s opinions delivered to the Placement Agent.
4.3 Comfort
Letters.
4.3.1. Cold
Comfort Letter. At the time this Agreement is executed the Placement Agent shall have received a cold comfort letter from the Auditor
containing statements and information of the type customarily included in accountants’ comfort letters with respect to the financial
statements and certain financial information contained or incorporated by reference or deemed incorporated by reference in the Registration
Statement, the Disclosure Package and the Prospectus, addressed to the Placement Agent and in form and substance satisfactory in all
respects to the Placement Agent, dated as of the date of this Agreement.
4.3.2. Bring-down
Comfort Letter. At each of the Closing Date the Placement Agent shall have received from the Auditor a letter, dated as of the Closing
Date, to the effect that the Auditor reaffirms the statements made in their letter furnished pursuant to Section 4.3.1, except that the
specified date referred to shall be a date not more than three (3) business days prior to the Closing Date.
4.4 Officers’
Certificates.
4.4.1. Officers’
Certificate. The Company shall have furnished to the Placement Agent a certificate, dated the Closing Date, of its Chief Executive
Officer and its Chief Financial Officer stating that (i) such officers have carefully examined the Registration Statement, the Disclosure
Package, any Issuer Free Writing Prospectus, and the Prospectus and, in their opinion, the Registration Statement and each amendment
thereto, as of the Applicable Time and as of the Closing Date did not include any untrue statement of a material fact and did not omit
to state a material fact required to be stated therein or necessary to make the statements therein not misleading, and the Disclosure
Package, as of the Applicable Time and as of the Closing Date, any Issuer Free Writing Prospectus as of its date and as of the Closing
Date and the Prospectus and each amendment or supplement thereto, as of the respective date thereof and as of the Closing Date did not
include any untrue statement of a material fact and did not omit to state a material fact necessary in order to make the statements therein,
in light of the circumstances in which they were made, not misleading, (ii) since the effective date of the Registration Statement, no
event has occurred which should have been set forth in a supplement or amendment to the Registration Statement, the Disclosure Package
or the Prospectus, (iii) to the best of their knowledge after reasonable investigation, as of the Closing Date the representations and
warranties of the Company in this Agreement are true and correct and the Company has complied with all agreements and satisfied all conditions
on its part to be performed or satisfied hereunder at or prior to the Closing Date and (iv) there has not been, subsequent to the date
of the most recent audited financial statements included or incorporated by reference in the Disclosure Package, any Material Adverse
Change in the financial position or results of operations of the Company, or any change or development that, singularly or in the aggregate,
would involve a Material Adverse Change or a prospective Material Adverse Change, in or affecting the condition (financial or otherwise),
results of operations, business, assets, or prospects of the Company, except as set forth in the Prospectus.
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4.4.2. Secretary’s
Certificate. On the Closing Date the Placement Agent shall have received a certificate of the Company signed by the Secretary of
the Company, dated the Closing Date, certifying: (i) that each of the Charter and similar governing documents is true and complete, has
not been modified and is in full force and effect; (ii) that the resolutions of the Board relating to the Offering are in full force
and effect and have not been modified; (iii) as to the accuracy and completeness of all correspondence between the Company or its counsel
and the Commission; and (iv) the good standing and the foreign qualification of the Company and its Subsidiaries; and (v) as to the incumbency
of the officers of the Company. The documents referred to in such certificate shall be attached to such certificate.
4.4.3. Officer’s
Certificate – Regulatory Matters. The Company shall have furnished to the Placement Agent a certificate, dated the Closing
Date, of its Chief Executive Officer and its Chief Financial Officer stating that, except as set forth in the Prospectus, the Company
(a) is in all material respects in compliance with the provisions of all laws relating to the regulation of the Company’s products,
including the Federal Food, Drug, and Cosmetic Act (the “FDC Act”) and all state laws comparable to the FDC Act, the
rules and regulations promulgated thereunder and all rules and regulations promulgated by the FDA and all comparable state regulatory
authorities, (b) has all authorizations, approvals, consents, orders, registrations, licenses or permits of any court or the FDA and
all state regulatory authorities comparable to the FDA which are necessary or required for it to conduct its current business in material
compliance with the FDC Act or comparable state law, and (c) the Prospectus and the Disclosure Package and the documents incorporated
by reference therein relating to the FDC Act, the FDA and all state laws comparable to the FDC Act, and the rules and regulations promulgated
thereunder and promulgated by the FDA, and related disclosures, are correct and complete in all material respects.
4.5 No
Material Changes. Prior to the Closing Date: (i) there shall have been no Material Adverse Change or development involving a prospective
Material Adverse Change from the latest dates as of which such condition is set forth in the Registration Statement and no change in
the capital stock or debt of the Company, the Disclosure Package, and the Prospectus; (ii) no action, suit, or proceeding, at law or
in equity, shall have been pending or threatened against the Company or any insider before or by any court or federal or state commission,
board, or other administrative agency wherein an unfavorable decision, ruling, or finding may materially adversely affect the business,
operations, properties, assets, prospects, or financial condition or income of the Company, except as set forth in the Registration Statement,
the Disclosure Package, and the Prospectus; (iii) no stop order shall have been issued under the Securities Act and no proceedings therefor
shall have been initiated or threatened by the Commission; (iv) no Cease Trade Order shall have been issued by any Canadian Securities
Regulator; (v) no action shall have been taken and no law, statute, rule, regulation, or order shall have been enacted, adopted, or issued
by any Governmental Entity which would prevent the issuance or sale of the Securities or materially and adversely affect or potentially
materially and adversely affect the business or operations of the Company; (vi) no injunction, restraining order, or order of any other
nature by any federal or state court of competent jurisdiction shall have been issued which would prevent the issuance or sale of the
Securities or materially and adversely affect or potentially materially and adversely affect the business or operations of the Company,
and (vii) the Registration Statement, the Disclosure Package, and the Prospectus and any amendments or supplements thereto shall contain
all material statements which are required to be stated therein in accordance with the Securities Act and the Securities Act Regulations
and shall conform in all material respects to the requirements of the Securities Act and the Securities Act Regulations, and neither
the Registration Statement, the Disclosure Package, the Prospectus, nor any amendment or supplement thereto shall contain any untrue
statement of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein,
in light of the circumstances under which they were made, not misleading.
4.6 No
Material Misstatement or Omission. The Placement Agent shall not have discovered and disclosed to the Company on or prior to the
Closing Date that the Registration Statement or any amendment or supplement thereto contains an untrue statement of a fact which, in
the opinion of Placement Agent Counsel, is material or omits to state any fact which, in the opinion of such counsel, is material and
is required to be stated therein or is necessary to make the statements therein not misleading, or that the Registration Statement, the
Disclosure Package, any Issuer Free Writing Prospectus or the Prospectus or any amendment or supplement thereto contains an untrue statement
of fact which, in the opinion of such counsel, is material or omits to state any fact which, in the opinion of such counsel, is material
and is necessary in order to make the statements, in the light of the circumstances under which they were made, not misleading.
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4.7 Corporate
Proceedings. All corporate proceedings and other legal matters incident to the authorization, form and validity of each of this Agreement,
the Pre-Funded Warrant Certificates, the Placement Agent’s Warrant Agreement, the Securities, the Registration Statement, the Disclosure
Package, and the Prospectus and all other legal matters relating to this Agreement, the Pre-Funded Warrant Certificates, the Placement
Agent’s Warrant Agreement and the transactions contemplated hereby and thereby shall be reasonably satisfactory in all material
respects to counsel for the Placement Agent, and the Company shall have furnished to such counsel all documents and information that
they may reasonably request to enable them to pass upon such matters.
4.8 Delivery
of Agreements.
4.8.1. Lock-Up
Agreements. On or before the date of this Agreement, the Company shall have delivered to the Placement Agent the executed copies
of the Lock-Up Agreements from each of the persons listed in Schedule 3 hereto.
4.8.2. Pre-Funded
Warrant Certificates. On the Closing Date, the Company shall deliver to the Placement Agent the executed copies of the Pre-Funded
Warrant Certificates in the form provided in Exhibit D.
4.8.3. Placement
Agent’s Warrant Agreement. On the Closing Date, the Company shall have delivered to the Placement Agent the executed copy of
the Placement Agent’s Warrant Agreement.
4.9 Additional
Documents. At the Closing Date, the Placement Agent Counsel shall have been furnished with such documents and opinions as they may
require for the purpose of enabling Placement Agent Counsel to deliver an opinion to the Placement Agent, or in order to evidence the
accuracy of any of the representations or warranties, or the fulfillment of any of the conditions, herein contained; and all proceedings
taken by the Company in connection with the issuance and sale of the Securities and the Placement Agent’s Warrant as herein contemplated
shall be satisfactory in form and substance to the Placement Agent and Placement Agent Counsel.
5. Indemnification.
5.1 Indemnification
of the Placement Agent.
5.1.1. General.
Subject to the conditions set forth below, the Company agrees to indemnify and hold harmless each Placement Agent, its affiliates, and
each of its and their respective directors, officers, members, employees, representatives, partners, shareholders, affiliates, counsel,
and agents and each person, if any, who controls any such Placement Agent within the meaning of Section 15 of the Securities Act or Section
20 of the Exchange Act (collectively the “Placement Agent Indemnified Parties,” and each an “Placement Agent
Indemnified Party”), against any and all loss, liability, claim, judgment, assessment, damage, and expense whatsoever (including
but not limited to any and all legal or other expenses reasonably incurred in investigating, preparing, or defending against any litigation,
commenced, or threatened, or any claim whatsoever, whether arising out of any action between any of the Placement Agent Indemnified Parties
and the Company or between any of the Placement Agent Indemnified Parties and any third party, or otherwise) to which they or any of
them may become subject under the Securities Act, the Exchange Act, or any other statute or at common law or otherwise or under the laws
of foreign countries (a “Claim”), arising out of or based upon any untrue statement or alleged untrue statement of
a material fact contained in (i) the Registration Statement, the Disclosure Package, any Preliminary Prospectus, the Prospectus, or any
Issuer Free Writing Prospectus or in any Written Testing-the-Waters Communication (as from time to time each may be amended and supplemented);
(ii) any materials or information provided to investors by, or with the approval of, the Company in connection with the marketing of
the Offering, including any “road show” or investor presentations made to investors by the Company (whether in person or
electronically); (iii) any application or other document or written communication (in this Section 5, collectively called “application”)
executed by the Company or based upon written information furnished by the Company in any jurisdiction in order to qualify the Securities
and, if applicable, the Placement Agent’s Securities under the securities laws thereof or filed with the Commission, any state
securities commission or agency, the Exchange, or any other national securities exchange or the TSX; or the omission or alleged omission
therefrom of a material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances
under which they were made, not misleading, unless such statement or omission was made in reliance upon, and in conformity with, the
Placement Agent’s Information; or (iv) otherwise arising in connection with or allegedly in connection with the Offering. The Company
also agrees that it will reimburse each Placement Agent Indemnified Party for all fees and expenses (including but not limited to any
and all legal or other expenses reasonably incurred in investigating, preparing, or defending against any litigation, commenced, or threatened,
or any claim whatsoever, whether arising out of any action between any of the Placement Agent Indemnified Parties and the Company or
between any of the Placement Agent Indemnified Parties and any third party, or otherwise) (collectively, the “Expenses”),
and further agrees wherever and whenever possible to advance payment of Expenses as they are incurred by an Placement Agent Indemnified
Party in investigating, preparing, pursuing or defending any Claim.
40
5.1.2. Procedure.
If any action is brought against an Placement Agent Indemnified Party in respect of which indemnity may be sought against the Company
pursuant to Section 5.1.1, such Placement Agent Indemnified Party shall promptly notify the Company in writing of the institution
of such action and the Company shall assume the defense of such action, including the employment and fees of counsel (subject to the
approval of such Placement Agent Indemnified Party) and payment of actual expenses if an Placement Agent Indemnified Party requests that
the Company do so. Such Placement Agent Indemnified Party shall have the right to employ its or their own counsel in any such case, but
the fees and expenses of such counsel shall be at the expense of the Company, and shall be advanced by the Company. The Company shall
not be liable for any settlement of any action effected without its consent (which shall not be unreasonably withheld). In addition,
the Company shall not, without the prior written consent of the Placement Agent, settle, compromise, or consent to the entry of any judgment
in or otherwise seek to terminate any pending or threatened action in respect of which advancement, reimbursement, indemnification, or
contribution may be sought hereunder (whether or not such Placement Agent Indemnified Party is a party thereto) unless such settlement,
compromise, consent, or termination (i) includes an unconditional release of each Placement Agent Indemnified Party, acceptable to such
Placement Agent Indemnified Party, from all liabilities, expenses, and claims arising out of such action for which indemnification or
contribution may be sought and (ii) does not include a statement as to or an admission of fault, culpability, or a failure to act, by
or on behalf of any Placement Agent Indemnified Party.
5.2 Indemnification
of the Company. The Placement Agent agrees to indemnify and hold harmless the Company, its directors, its officers who signed the
Registration Statement and persons who control the Company within the meaning of Section 15 of the Securities Act or Section 20 of the
Exchange Act against any and all loss, liability, claim, judgment, assessment, damage and expense described in the foregoing indemnity
from the Company to the Placement Agent, as incurred, but only with respect to untrue statements or omissions made in the Registration
Statement, any Preliminary Prospectus, the Disclosure Package or Prospectus or any amendment or supplement thereto or in any application,
in reliance upon, and in strict conformity with, the Placement Agent’s Information. In case any action shall be brought against
the Company or any other person so indemnified based on any Preliminary Prospectus, the Registration Statement, the Disclosure Package
or Prospectus or any amendment or supplement thereto or any application, and in respect of which indemnity may be sought against the
Placement Agent, the Placement Agent shall have the rights and duties given to the Company, and the Company and each other person so
indemnified shall have the rights and duties given to the Placement Agent by the provisions of Section 5.1.2. The Company agrees promptly
to notify the Placement Agent of the commencement of any litigation or proceedings against the Company or any of its officers, directors
or any person, if any, who controls the Company within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange
Act, in connection with the issuance and sale of the Securities or in connection with the Registration Statement, the Disclosure Package,
the Prospectus, or any Issuer Free Writing Prospectus or any Written Testing-the-Waters Communication.
41
5.3 Contribution.
5.3.1. Contribution
Rights. If the indemnification provided for in this Section 5 shall for any reason be unavailable to or insufficient to hold
harmless an indemnified party under Section 5.1 in respect of any loss, claim, judgment, assessment, damage, expense or liability,
or any action in respect thereof, referred to therein, then each indemnifying party shall, in lieu of indemnifying such indemnified party,
contribute to the amount paid or payable by such indemnified party as a result of such loss, claim, judgment, assessment, damage, expense
or liability, or action in respect thereof, (i) in such proportion as shall be appropriate to reflect the relative benefits received
by the Company, on the one hand, and the Placement Agent, on the other, from the Offering of the Securities, or (ii) if the allocation
provided by clause (i) above is not permitted by applicable law, in such proportion as is appropriate to reflect not only the relative
benefits referred to in clause (i) above but also the relative fault of the Company, on the one hand, and the Placement Agent, on the
other, with respect to the statements or omissions that resulted in such loss, claim, judgment, assessment, damage, expense or liability,
or action in respect thereof, as well as any other relevant equitable considerations. The relative benefits received by the Company,
on the one hand, and the Placement Agent, on the other, with respect to such Offering shall be deemed to be in the same proportion as
the total net proceeds from the Offering of the Securities purchased under this Agreement (before deducting expenses) received by the
Company, as set forth in the table on the cover page of the Prospectus, on the one hand, and the total discounts and commissions received
by the Placement Agent with respect to the Common Shares purchased under this Agreement, as set forth in the table on the cover page
of the Prospectus, on the other hand. The relative fault shall be determined by reference to whether the untrue or alleged untrue statement
of a material fact or omission or alleged omission to state a material fact relates to information supplied by the Company or the Placement
Agent, the intent of the parties and their relative knowledge, access to information, and opportunity to correct or prevent such statement
or omission. The Company and the Placement Agent agree that it would not be just and equitable if contributions pursuant to this Section
5.3.1 were to be determined by pro rata allocation (even if the Placement Agent were treated as one entity for such purpose) or by
any other method of allocation that does not take into account the equitable considerations referred to herein. The amount paid or payable
by an indemnified party as a result of the loss, claim, judgment, assessment, damage, expense or liability, or action in respect thereof,
referred to above in this Section 5.3.1 shall be deemed to include, for purposes of this Section 5.3.1, any legal or other
expenses reasonably incurred by such indemnified party in connection with investigating or defending any such action or claim. Notwithstanding
the provisions of this Section 5.3.1 in no event shall an Placement Agent be required to contribute any amount in excess of the
amount by which the total discounts and commissions received by such Placement Agent with respect to the Offering of the Securities exceed
the amount of any damages that such Placement Agent has otherwise been required to pay by reason of such untrue or alleged untrue statement
or omission or alleged omission. No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities
Act) shall be entitled to contribution from any person who was not guilty of such fraudulent misrepresentation.
42
5.3.2. Contribution
Procedure. Within fifteen (15) days after receipt by any party to this Agreement (or its representative) of notice of the commencement
of any action, suit, or proceeding, such party will, if a claim for contribution in respect thereof is to be made against another party
(“contributing party”), notify the contributing party of the commencement thereof, but the failure to so notify the contributing
party will not relieve it from any liability which it may have to any other party other than for contribution hereunder. In case any
such action, suit, or proceeding is brought against any party, and such party notifies a contributing party or its representative of
the commencement thereof within the aforesaid fifteen (15) days, the contributing party will be entitled to participate therein with
the notifying party and any other contributing party similarly notified. Any such contributing party shall not be liable to any party
seeking contribution on account of any settlement of any claim, action, or proceeding affected by such party seeking contribution on
account of any settlement of any claim, action, or proceeding affected by such party seeking contribution without the written consent
of such contributing party. The contribution provisions contained in this Section 5.3.2 are intended to supersede, to the extent
permitted by law, any right to contribution under the Securities Act, the Exchange Act, or otherwise available.
6. [RESERVED].
7. Additional
Covenants.
7.1 Board
Composition and Board Designations. The Company shall ensure that: (i) the qualifications of the persons serving as members of the
Board and the overall composition of the Board comply with the Sarbanes-Oxley Act, with the Exchange Act and with the listing rules of
the Exchange or any other national securities exchange, as the case may be, in the event the Company seeks to have its Securities listed
on another exchange or quoted on an automated quotation system, and (ii) if applicable, at least one member of the Audit Committee of
the Board qualifies as an “audit committee financial expert,” as such term is defined under Regulation S-K and the listing
rules of the Exchange.
7.2 Right
of First Refusal. Provided that the Shares are sold in accordance with the terms of this Agreement, the Placement Agent shall have
an irrevocable right of first refusal (the “Right of First Refusal”), for a period of twelve (12) months after the
date the Offering is completed, to act as sole and exclusive investment banker, sole and exclusive book-runner, sole and exclusive financial
advisor, sole and exclusive underwriter and/or sole and exclusive placement agent, at the Placement Agent’s sole and exclusive
discretion, for each and every future public and private equity and debt offering, including all equity linked financings (each, a “Subject
Transaction”), during such twelve (12) month period, of the Company, or any successor to or subsidiary of the Company, on terms
and conditions customary to the Placement Agent for such Subject Transactions. The Placement Agent will have the sole right to determine
whether or not any other broker dealer will have the right to participate in any Subject Transaction and the economic terms of any such
participation. For the avoidance of any doubt, the Company shall not retain, engage or solicit any additional investment banker, book-runner,
financial advisor, underwriter and/or placement agent in a Subject Transaction without the express written consent of the Placement Agent.
The
Company shall notify the Placement Agent of its intention to pursue a Subject Transaction, including the material terms thereof, by providing
written notice thereof by registered mail or overnight courier service addressed to the Placement Agent. If the Placement Agent fails
to exercise its Right of First Refusal with respect to any Subject Transaction within ten (10) Business Days after the receipt of such
written notice, then the Placement Agent shall have no further claim or right with respect to the Subject Transaction. The Placement
Agent may elect, in its sole and absolute discretion, not to exercise its Right of First Refusal with respect to any Subject Transaction;
provided that any such election by the Placement Agent shall not adversely affect the Placement Agent’s Right of First Refusal
with respect to any other Subject Transaction during the twelve (12) month period agreed to above.
43
8. Effective
Date of this Agreement and Termination Thereof.
8.1 Effective
Date. This Agreement shall become effective when both the Company and the Placement Agent have executed the same and delivered counterparts
of such signatures to the other party.
8.2 Termination.
The Placement Agent shall have the right to terminate this Agreement at any time prior to the Closing Date, (i) if any domestic or international
event or act or occurrence has materially disrupted, or in the Placement Agent’s opinion will in the immediate future materially
disrupt, general securities markets in the United States; or (ii) if trading on the New York Stock Exchange or The Nasdaq Stock Market
LLC shall have been suspended or materially limited, or minimum or maximum prices for trading shall have been fixed, or maximum ranges
for prices for securities shall have been required by FINRA or by order of the Commission or any other government authority having jurisdiction;
or (iii) if the United States shall have become involved in a new war or an increase in major hostilities; or (iv) if a banking moratorium
has been declared by a New York State or federal authority; or (v) if a moratorium on foreign exchange trading has been declared which
materially adversely impacts the United States securities markets; or (vi) if the Company shall have sustained a material loss by fire,
flood, accident, hurricane, earthquake, theft, sabotage, or other calamity or malicious act which, whether or not such loss shall have
been insured, will, in the Placement Agent’s opinion, make it inadvisable to proceed with the delivery of the Securities; or (vii)
if the Company is in material breach of any of its representations, warranties, or covenants hereunder; or (viii) if the Placement Agent
shall have become aware after the date hereof of such a Material Adverse Change in the conditions or prospects of the Company, or such
Material Adverse Change in general market conditions as in the Placement Agent’s judgment would make it impracticable to proceed
with the offering, sale, and/or delivery of the Securities or to enforce contracts made by the Placement Agent for the sale of the Securities;
or (ix) if trading of the Common Shares or Public Warrants on the Exchange shall be suspended on or prior to the Closing Date.
8.3 Expenses.
Notwithstanding anything to the contrary in this Agreement, in the event that this Agreement shall not be carried out for any reason
whatsoever, within the time specified herein or any extensions thereof pursuant to the terms herein, the Company shall be obligated to
pay to the Placement Agent their actual and accountable out-of-pocket expenses related to the transactions contemplated herein as set
forth in Section 3.11 herein, and upon demand the Company shall pay the full amount thereof to the Placement Agent; provided,
however, that such expense cap in no way limits or impairs the indemnification and contribution provisions of this Agreement.
Notwithstanding the foregoing, any advance received by the Placement Agent will be reimbursed to the Company to the extent not actually
incurred in compliance with FINRA Rule 5110(g)(4)(A).
8.4 Survival
of Indemnification. Notwithstanding any contrary provision contained in this Agreement, any election hereunder or any termination
of this Agreement, and whether or not this Agreement is otherwise carried out, the provisions of Section 5 shall remain in full
force and effect and shall not be in any way affected by, such election or termination or failure to carry out the terms of this Agreement
or any part hereof.
8.5 Representations,
Warranties, Agreements to Survive. All representations, warranties, and agreements contained in this Agreement or in certificates
of officers of the Company submitted pursuant hereto, shall remain operative and in full force and effect regardless of (i) any investigation
made by or on behalf of the Placement Agent or its Affiliates or selling agents, any person controlling the Placement Agent, its officers,
or directors or any person controlling the Company, or (ii) delivery of and payment for the Securities.
44
9. Miscellaneous.
9.1 Notices.
All communications hereunder, except as herein otherwise specifically provided, shall be in writing and shall be mailed (registered or
certified mail, return receipt requested), personally delivered or sent by electronic mail transmission and confirmed and shall be deemed
given when so delivered and confirmed or if mailed, two (2) days after such mailing.
(a) If
to the Placement Agent:
ThinkEquity
LLC
17
State Street, 41st Floor
New
York, NY 10004
Attention:
Head of Investment Banking
e-mail:
Notices@think-equity.com
with
a copy (which shall not constitute notice) to:
Cozen
O’Connor LLP
Bentall
5, 550 Burrard Street, Suite 2501
Vancouver,
British Columbia, V6C 2B5, Canada
Attention:
Mr. Virgil Hlus
Email:
VHlus@cwilson.com
(b) If
to the Company:
BriaCell
Therapeutics Corp.
Suite
300, Bellevue Centre
235
– 15th Street
West
Vancouver, BC V7T 2X1, Canada
Attention:
Dr. William V. Williams
Email:
william@briacell.com
with
a copy (which shall not constitute notice) to:
Sichenzia
Ross Ference Carmel LLP
1185
Ave. of the Americas, 26th Floor
New
York, NY 10036
Attn:
Gregory Sichenzia, Esq.
e-mail:
gsichenzia@srfc.law
9.2 Research
Analyst Independence. The Company acknowledges that the Placement Agent’s research analysts and research departments are required
to be independent from its investment banking division and are subject to certain regulations and internal policies, and that such Placement
Agent’s research analysts may hold views and make statements or investment recommendations and/or publish research reports with
respect to the Company and/or the Offering that differ from the views of their investment banking division. The Company acknowledges
that the Placement Agent is a full service securities firm and as such from time to time, subject to applicable securities laws, rules
and regulations, may effect transactions for its own account or the account of its customers, and hold long or short positions in debt
or equity securities of the Company; provided, however, that nothing in this Section 9.2 shall relieve the Placement
Agent of any responsibility or liability it may otherwise bear in connection with activities in violation of applicable securities laws,
rules or regulations.
45
9.3 Headings.
The headings contained herein are for the sole purpose of convenience of reference, and shall not in any way limit or affect the meaning
or interpretation of any of the terms or provisions of this Agreement.
9.4 Amendment.
This Agreement may only be amended by a written instrument executed by each of the parties hereto.
9.5 Entire
Agreement. This Agreement (together with the other agreements and documents being delivered pursuant to or in connection with this
Agreement) constitutes the entire agreement of the parties hereto with respect to the subject matter hereof and thereof, and supersedes
all prior agreements and understandings of the parties, oral and written, with respect to the subject matter hereof. Notwithstanding
anything to the contrary set forth herein, it is understood and agreed by the parties hereto that all other terms and conditions of that
certain engagement letter between the Company and ThinkEquity LLC dated April 22, 2026, shall remain in full force and effect.
9.6 Binding
Effect. This Agreement shall inure solely to the benefit of and shall be binding upon the Placement Agent, the Company, and the controlling
persons, directors, and officers referred to in Section 5 hereof, and their respective successors, legal representatives, heirs,
and assigns, and no other person shall have or be construed to have any legal or equitable right, remedy, or claim under or in respect
of or by virtue of this Agreement or any provisions herein contained. The term “successors and assigns” shall not include
a purchaser, in its capacity as such, of securities from the Placement Agent.
9.7 Governing
Law; Consent to Jurisdiction; Trial by Jury. This Agreement shall be governed by and construed and enforced in accordance with the
laws of the State of New York, without giving effect to conflict of laws principles thereof. The Company hereby agrees that any action,
proceeding, or claim against it arising out of, or relating in any way to this Agreement shall be brought and enforced in the New York
Supreme Court, County of New York, or in the United States District Court for the Southern District of New York, and irrevocably submits
to such jurisdiction, which jurisdiction shall be exclusive. The Company hereby waives any objection to such exclusive jurisdiction and
that such courts represent an inconvenient forum. Any such process or summons to be served upon the Company may be served by transmitting
a copy thereof by registered or certified mail, return receipt requested, postage prepaid, addressed to it at the address set forth in
Section 9.1 hereof. Such mailing shall be deemed personal service and shall be legal and binding upon the Company in any action,
proceeding, or claim. The Company agrees that the prevailing party(ies) in any such action shall be entitled to recover from the other
party(ies) all of its reasonable attorneys’ fees and expenses relating to such action or proceeding and/or incurred in connection
with the preparation therefor. The Company (on its behalf and, to the extent permitted by applicable law, on behalf of its shareholders
and affiliates) and the Placement Agent hereby irrevocably waives, to the fullest extent permitted by applicable law, any and all right
to trial by jury in any legal proceeding arising out of or relating to this Agreement or the transactions contemplated hereby.
9.8 Execution
in Counterparts. This Agreement may be executed in one or more counterparts, and by the different parties hereto in separate counterparts,
each of which shall be deemed to be an original, but all of which taken together shall constitute one and the same agreement, and shall
become effective when one or more counterparts has been signed by each of the parties hereto and delivered to each of the other parties
hereto. Delivery of a signed counterpart of this Agreement by facsimile or email/pdf transmission shall constitute valid and sufficient
delivery thereof.
9.9 Waiver,
etc. The failure of any of the parties hereto to at any time enforce any of the provisions of this Agreement shall not be deemed
or construed to be a waiver of any such provision, nor to in any way effect the validity of this Agreement or any provision hereof or
the right of any of the parties hereto to thereafter enforce each and every provision of this Agreement. No waiver of any breach, non-
compliance or non-fulfillment of any of the provisions of this Agreement shall be effective unless set forth in a written instrument
executed by the party or parties against whom or which enforcement of such waiver is sought; and no waiver of any such breach, non-compliance
or non-fulfillment shall be construed or deemed to be a waiver of any other or subsequent breach, non-compliance or non-fulfillment.
9.10 Currency
Matters. As used herein, “$” refers to U.S. dollars.
[Signature
Page Follows]
46
If
the foregoing correctly sets forth the understanding between the Placement Agent and the Company, please so indicate in the space provided
below for that purpose, whereupon this letter shall constitute a binding agreement between us.
Very
truly yours,
BRIACELL
THERAPEUTICS CORP.
By:
Confirmed
as of the date first written
above
mentioned:
THINKEQUITY
LLC
By:
[SIGNATURE
PAGE TO PLACEMENT AGENCY AGREEMENT]
SCHEDULE
1
Terms
Number
of Shares: 1,449,300
Number
of Pre-Funded Warrants: Nil
Offering
Price per Share: US$3.25
Offering
Price per Pre-Funded Warrant: US$3.249
Proceeds
to Company (before placement agent fees, expenses and exercise of pre-funded warrants): US$4,710,225
SCHEDULE
2-A
Issuer
General Use Free Writing Prospectuses
None.
SCHEDULE
2-B
Written
Testing-the-Waters Communications
None.
SCHEDULE
3
List
of Lock-Up Parties
Name
Position
Dr.
William V. Williams
President,
Chief Executive Officer and Director
Gadi
Levin
Chief
Financial Officer and Corporate Secretary
Dr.
Giuseppe Del Priore
Chief
Medical Officer
Dr.
Miguel A. Lopez Lago
Chief
Scientific Officer
Jamieson
Bondarenko
Chairman,
Director
Dr.
Rebecca Taub
Director
Vaughn
C. Embro-Pantalony
Director
Martin
Schmieg
Director
Dr.
Jane Gross
Director
SCHEDULE
4
Company
Investors
None
EX-99.1
EX-99.1
Filename: ex99-1.htm · Sequence: 5
Exhibit
99.1
BriaCell
Therapeutics Announces Pricing of Offering
Philadelphia
& Vancouver, British Columbia – May 31, 2026 – BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXL, BCTXZ) (TSX: BCT)
(“BriaCell” or the “Company”), a clinical-stage biotechnology company developing novel immunotherapies to transform
cancer care, today announced the pricing of a best-efforts offering of 1,449,300 common shares. Each common share is being sold at an
offering price of $3.25 per share. All of the common shares in the offering are being offered by the Company. Total gross proceeds from
the offering, before deducting placement agent’s fees and other offering expenses, are expected to be approximately $4.7 million.
The offering is expected to close on June 2, 2026, subject to satisfaction of customary closing conditions. The Company is relying upon
the exemption set forth in Section 602.1 of the TSX Company Manual, which provides that the TSX will not apply its standards to certain
transactions involving eligible interlisted issuers on a recognized exchange, such as Nasdaq.
The
Company intends to use the net proceeds from the offering for working capital requirements, general corporate purposes, and the advancement
of business objectives.
ThinkEquity
is acting as sole placement agent for the offering.
The
securities described above are being offered and sold by the Company pursuant to a shelf registration statement on Form S-3 (File No.
333-276650), including a base prospectus, filed with the U.S. Securities and Exchange Commission (the “SEC”) on January 22,
2024 and declared effective on January 31, 2024. The offering is being made only by means of a written prospectus. A final prospectus
supplement and accompanying prospectus relating to the offering will be filed with the SEC and can be accessed for free on the SEC’s
website at www.sec.gov. Copies of the final prospectus supplement and the accompanying prospectus relating to the offering may be obtained,
when available, from the offices of ThinkEquity, 17 State Street, 41st Floor, New York, New York 10004.
This
press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor shall there be any sale of these securities
in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under
the securities laws of any such state or jurisdiction.
About
BriaCell Therapeutics Corp.
BriaCell
is an immuno-oncology-focused biotechnology company developing targeted and effective approaches for the management of cancer. More information
is available at https://briacell.com/.
Forward-Looking
Statements
This
press release contains “forward-looking statements” that are subject to substantial risks and uncertainties. All statements,
other than statements of historical fact, contained in this press release are forward-looking statements. Forward-looking statements
contained in this press release may be identified by the use of words such as “anticipate,” “believe,” “contemplate,”
“could,” “estimate,” “expect,” “intend,” “seek,” “may,” “might,”
“plan,” “potential,” “predict,” “project,” “target,” “aim,” “should,”
“will,” “would,” or the negative of these words or other similar expressions, although not all forward-looking
statements contain these words. Forward-looking statements are based on BriaCell’s current expectations and are subject to inherent
uncertainties, risks, and assumptions that are difficult to predict. Further, certain forward-looking statements are based on assumptions
as to future events that may not prove to be accurate. These and other risks and uncertainties are described more fully under the heading
“Risk Factors” in the Company’s most recent Annual Report on Form 10-K, and under “Risks and Uncertainties”
in the Company’s other filings with the Canadian securities regulatory authorities and the U.S. Securities and Exchange Commission,
all of which are available under the Company’s profiles on SEDAR+ at www.sedarplus.ca and on EDGAR at www.sec.gov. Forward-looking
statements contained in this announcement are made as of this date, and BriaCell Therapeutics Corp. undertakes no duty to update such
information except as required under applicable law.
Neither
the Toronto Stock Exchange nor its Regulation Services Provider (as that term is defined in the policies of the Toronto Stock Exchange)
accepts responsibility for the adequacy or accuracy of this release.
Contact
Information
Company
Contact:
William
V. Williams, MD
President
& CEO
1-888-485-6340
info@briacell.com
Investor
Relations Contact:
investors@briacell.com
EX-99.2
EX-99.2
Filename: ex99-2.htm · Sequence: 6
Exhibit 99.2
BriaCell
Therapeutics Announces Closing of Offering
Philadelphia
& Vancouver, British Columbia – June 2, 2026 – BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXL, BCTXZ) (TSX: BCT)
(“BriaCell” or the “Company”), a clinical-stage biotechnology company developing novel immunotherapies to transform
cancer care, today announced the closing of its best-efforts offering of 1,449,300 common shares. Each common share was sold at an offering
price of $3.25 per share. All of the common shares in the offering were offered by the Company. Total gross proceeds from the offering,
before deducting placement agent’s fees and other offering expenses, were approximately $4.7 million. The Company relied upon the
exemption set forth in Section 602.1 of the TSX Company Manual, which provides that the TSX will not apply its standards to certain transactions
involving eligible interlisted issuers on a recognized exchange, such as Nasdaq.
The
Company intends to use the net proceeds from the offering for working capital requirements, general corporate purposes, and the advancement
of business objectives.
ThinkEquity
acted as the sole placement agent for the offering.
The
securities described above were offered and sold by the Company pursuant to a shelf registration statement on Form S-3 (File No. 333-276650),
including a base prospectus, filed with the U.S. Securities and Exchange Commission (the “SEC”) on January 22, 2024 and declared
effective on January 31, 2024. The offering was made only by means of a written prospectus. A final prospectus supplement and accompanying
prospectus relating to the offering has been filed with the SEC and can be accessed for free on the SEC’s website at www.sec.gov.
Copies of the final prospectus supplement and the accompanying prospectus relating to the offering may be obtained, when available, from
the offices of ThinkEquity, 17 State Street, 41st Floor, New York, New York 10004.
This
press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor shall there be any sale of these securities
in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under
the securities laws of any such state or jurisdiction.
About
BriaCell Therapeutics Corp.
BriaCell
is an immuno-oncology-focused biotechnology company developing targeted and effective approaches for the management of cancer. More information
is available at https://briacell.com/.
Forward-Looking
Statements
This
press release contains “forward-looking statements” that are subject to substantial risks and uncertainties. All statements,
other than statements of historical fact, contained in this press release are forward-looking statements. Forward-looking statements
contained in this press release may be identified by the use of words such as “anticipate,” “believe,” “contemplate,”
“could,” “estimate,” “expect,” “intend,” “seek,” “may,” “might,”
“plan,” “potential,” “predict,” “project,” “target,” “aim,” “should,”
“will,” “would,” or the negative of these words or other similar expressions, although not all forward-looking
statements contain these words. Forward-looking statements are based on BriaCell’s current expectations and are subject to inherent
uncertainties, risks, and assumptions that are difficult to predict. Further, certain forward-looking statements are based on assumptions
as to future events that may not prove to be accurate. These and other risks and uncertainties are described more fully under the heading
“Risk Factors” in the Company’s most recent Annual Report on Form 10-K, and under “Risks and Uncertainties”
in the Company’s other filings with the Canadian securities regulatory authorities and the U.S. Securities and Exchange Commission,
all of which are available under the Company’s profiles on SEDAR+ at www.sedarplus.ca and on EDGAR at www.sec.gov. Forward-looking
statements contained in this announcement are made as of this date, and BriaCell Therapeutics Corp. undertakes no duty to update such
information except as required under applicable law.
Neither
the Toronto Stock Exchange nor its Regulation Services Provider (as that term is defined in the policies of the Toronto Stock Exchange)
accepts responsibility for the adequacy or accuracy of this release.
Contact
Information
Company
Contact:
William
V. Williams, MD
President
& CEO
1-888-485-6340
info@briacell.com
Investor
Relations Contact:
investors@briacell.com
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