Form 8-K
8-K — Serina Therapeutics, Inc.
Accession: 0001708599-26-000036
Filed: 2026-05-14
Period: 2026-05-14
CIK: 0001708599
SIC: 2834 (PHARMACEUTICAL PREPARATIONS)
Item: Results of Operations and Financial Condition
Item: Financial Statements and Exhibits
Documents
8-K — ser-20260514.htm (Primary)
EX-99.1 (ser-20260514xex991_earning.htm)
XML — IDEA: XBRL DOCUMENT (R1.htm)
8-K
8-K (Primary)
Filename: ser-20260514.htm · Sequence: 1
ser-20260514
0001708599false00017085992026-05-142026-05-14
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (date of earliest event reported): May 14, 2026
Serina Therapeutics, Inc.
(Exact name of registrant as specified in its charter)
Delaware 1-38519 82-1436829
(State or other jurisdiction
of incorporation) (Commission
File Number) (IRS Employer
Identification No.)
601 Genome Way, Suite 2001
Huntsville, Alabama 35806
(Address of principal executive offices)
(256) 327-9630
(Registrant’s telephone number, including area code)
Not applicable
(Former name or former address, if changed since last report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
o Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Securities registered pursuant to Section 12(b) of the Act:
Title of each class Trading Symbol Name of exchange on which registered
Common Stock, par value $0.0001 per share SER NYSE American
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter). Emerging growth company o
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. o
References in this Report to “Serina,” the "Company,” “we” or “us” or similar terms refer to Serina Therapeutics, Inc. refer to Serina Therapeutics, Inc. and its subsidiaries.
Item 2.02 Results of Operations and Financial Condition
On May 14, 2026, the Company issued a press release announcing its financial results for the quarter ended March 31, 2026. A copy of the press release is furnished as Exhibit 99.1 hereto.
The information in this Item 2.02 and in the press release furnished as Exhibit 99.1 to this current report shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and is not to be incorporated by reference into any filing of the registrant under the Securities Act of 1933, as amended, or the Exchange Act, whether made before or after the date hereof, regardless of any general incorporation language in any such filing, except as shall be expressly set forth by specific reference in such a filing.
Item 9.01 - Financial Statements and Exhibits.
(d) Exhibits
Exhibit
Number Description
99.1
Press Release of Serina Therapeutics, Inc. issued on May 14, 2026
104 Cover Page Interactive Data File (embedded within the Inline XBRL document)
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
SERINA THERAPEUTICS, INC.
Date: May 14, 2026
By: /s/ Steve Ledger
Chief Executive Officer
EX-99.1
EX-99.1
Filename: ser-20260514xex991_earning.htm · Sequence: 2
Document
Exhibit 99.1
Serina Therapeutics Reports First Quarter 2026 Financial Results and Provides Business Updates
–Phase 1b Registrational Clinical Study of SER-252 Underway in Advanced Parkinson’s Disease; TFL data from the SAD study arm targeted for first half of 2027 -
–Closed $21.2 million private placement financing to support continued advancement of SER-252 -
HUNTSVILLE, May 14, 2026 (GLOBE NEWSWIRE) — Serina Therapeutics, Inc. (“Serina” or the "Company") (NYSE American: SER), a clinical-stage biotechnology company developing its proprietary POZ Platform™ drug optimization technology, today reported its financial results for the first quarter ended March 31, 2026, along with key business updates.
“With our Phase 1b registrational study of SER-252 now underway and a strengthened balance sheet, Serina is entering an important execution phase as we work toward our first clinical data in patients with advanced Parkinson’s disease,” said Steve Ledger, Chief Executive Officer of Serina. “SER-252 represents the first clinical validation of our POZ Platform™, which is designed to optimize well-understood therapeutics by improving pharmacokinetics, tolerability and dosing profiles. We believe this approach has the potential to unlock meaningful value across multiple modalities, and we are building a pipeline and partnership strategy to fully leverage the breadth of the platform.”
•SER-252 Phase 1b Registrational Clinical Study: Following dosing of the first patient in February 2026, Serina continues to advance its Phase 1b registrational clinical study of SER-252 in advanced Parkinson’s disease. The Company anticipates completing enrollment and dosing of Cohort 1 by the end of the third quarter of 2026 and is targeting availability of TFL data from the SAD study arm in the first half of 2027.
•Closed Private Placement Financing: In March and April 2026, Serina closed the previously announced private placement of common stock, redeemable warrants and pre-funded warrants, resulting in aggregate gross proceeds of $21.2 million ("March 2026 PIPE"). In connection with the initial closing, the Senior Unsecured Convertible Promissory Note entered into on September 9, 2025 was amended to remove any further obligations to borrow or loan funds under the note. The closing also satisfied the requirements for the automatic conversion of all outstanding shares of Series A Preferred Stock, together with any accrued but unissued PIK Shares, into shares of Serina common stock.
First Quarter Operating Results
Operating expenses: Operating expenses for the three months ended March 31, 2026 and 2025 were $6.3 million and $5.9 million, respectively.
Research and Development (R&D) Expenses: R&D expenses were $3.2 million for the three months ended March 31, 2026, compared to $3.0 million for the same period in 2025.
General and Administrative Expenses: General and administrative expenses were $3.1 million for the three months ended March 31, 2026, compared to $2.9 million for the same period in 2025.
Other Expense, Net: Other expense was $0.6 million for the three months ended March 31, 2026 compared to $1.0 million other income for the same period in 2025. The $1.6 million increase in expenses was primarily attributable to a non-cash loss on extinguishment of financial commitment assets and contingent warrants from the amendment of the Senior Unsecured Convertible Promissory Note in connection with the March 2026 PIPE.
Net Loss: The net loss attributable to Serina for the three months ended March 31, 2026 was $6.9 million, or $(0.58) per basic and diluted share, compared to net loss of $4.8 million, or $(0.49) per basic and diluted share for 2025.
Cash and cash equivalents totaled $24.5 million as of March 31, 2026. In addition, gross proceeds of $5.2 million were received in April 2026 from the March 2026 PIPE.
About Serina Therapeutics
Serina is a clinical-stage biotechnology company developing a pipeline of wholly owned drug product candidates to treat neurological diseases and other indications. Serina’s POZ PlatformTM provides the potential to improve the integrated efficacy and safety profile of multiple modalities including small molecules, RNA-based therapeutics and antibody-based drug conjugates (ADCs). Serina is headquartered in Huntsville, Alabama on the campus of the HudsonAlpha Institute of Biotechnology.
About the POZ Platform™
Serina’s proprietary POZ technology is based on a synthetic, water soluble, low viscosity polymer called poly(2-oxazoline). Serina’s POZ technology is engineered to provide greater control in drug loading and more precision in the rate of release of attached drugs delivered via subcutaneous injection. The therapeutic agents in Serina’s product candidates are typically well-understood and marketed drugs that are effective but are limited by pharmacokinetic profiles that can include toxicity, side effects and short half-life. Serina believes that by using POZ technology, drugs with narrow therapeutic windows can be designed to maintain more desirable and stable levels in the blood.
Serina’s POZ platform delivery technology has potential for use across a broad range of payloads and indications. Serina intends to advance additional applications of the POZ platform via out-licensing, co-development, or other partnership arrangements, including the non-exclusive license agreement with Pfizer, Inc. to use Serina’s POZ polymer technology for use in lipid nanoparticle drug (LNP) delivery formulations.
About SER-252 (POZ-apomorphine)
SER 252 is an investigational apomorphine therapy developed with Serina’s POZ platform and designed to provide continuous dopaminergic stimulation (CDS). CDS has been shown to reduce the severity of levodopa-related motor complications (dyskinesia) in Parkinson’s disease. Preclinical studies support the potential of SER 252 to provide CDS without skin reactions. Serina has advanced SER 252 into the clinic in February 2026.
SER-252 Registrational Study Design Overview
The SER-252-1b study is a randomized, double-blind, placebo-controlled Phase 1b trial with single-ascending-dose (five cohorts of eight; n=40) and multiple-ascending-dose components (up to three cohorts of sixteen; n=48) in adults with Parkinson’s disease and motor fluctuations. The registrational study is designed to evaluate safety, tolerability, and pharmacokinetics of subcutaneous SER-252 versus placebo, with exploratory efficacy measures that include MDS-UPDRS motor scores and structured motor-state assessments. Dose escalation will be overseen by a Safety Review Committee and the study will be conducted across sites in the U.S. and Australia.
For more information, please visit https://serinatx.com.
Cautionary Statement Regarding Forward-Looking Statement
This release contains forward-looking statements within the meaning of federal securities laws that involve substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. These statements are based on management’s current expectations, plans, beliefs or forecasts for the future, and are subject to uncertainty and changes in circumstances. The facts and assumptions underlying these statements may change, and undue reliance should not be placed on these forward-looking statements which speak only as of the date they are made. Any statements that are not historical fact (including, but not limited to statements that contain words such as “may,” “will,” “believes,” “plans,” “intends,” “anticipates,” "targeting," “expects,” or “estimates”) should be considered to be forward-looking statement, including statements about the potential of Serina’s POZ polymer technology, Serina’s estimates regarding future revenue, expenses, capital requirements and need for additional financing, and Serina’s planned clinical programs, including planned clinical trials. Risks and uncertainties include, among other things, the uncertainties inherent in research and development, including the ability to meet anticipated clinical endpoints, commencement and/or completion dates for clinical trials, regulatory holds, regulatory submission dates, regulatory approval dates and/or launch dates, as well as the possibility of unfavorable new clinical data and further analyses of existing clinical data; Serina’s ability to continue as a going concern; the risk that clinical trial data are subject to differing interpretations and assessments by regulatory authorities; whether regulatory authorities will be satisfied with the design of and results from our clinical studies; whether and when any applications may be filed for any drug or vaccine candidates in any jurisdictions; whether and when regulatory authorities may approve any potential applications that may be filed for any drug or vaccine candidates in any jurisdictions, which will depend on a myriad of factors, including making a determination as to whether the product’s benefits outweigh its known risks and determination of the product’s efficacy and, if approved, whether any such drug or vaccine candidates will be commercially successful; decisions by regulatory authorities impacting labeling,
manufacturing processes, safety and/or other matters that could affect the availability or commercial potential of any drug or vaccine candidates; and competitive developments. These risks as well as other risks are more fully discussed in the company’s Annual Report on Form 10-K for the year ended December 31, 2025, and the company’s other periodic reports and documents filed from time to time with the SEC. The information contained in this release is as of the date hereof, and, except as required by law, Serina assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments.
For inquiries, please contact:
Stefan Riley
sriley@serinatherapeutics.com
(256) 327-9630
SERINA THERAPEUTICS, INC.
CONDENSED CONSOLIDATED BALANCE SHEETS
(in thousands)
(Unaudited)
March 31, 2026 December 31, 2025
ASSETS
Current assets:
Cash and cash equivalents $ 24,526 $ 3,056
Prepaid expenses and other current assets 1,948 3,024
Total current assets 26,474 6,080
Property and equipment, net 472 465
Right of use assets - operating leases 328 377
Other long-term prepaid assets 25 29
TOTAL ASSETS $ 27,299 $ 6,951
LIABILITIES AND STOCKHOLDERS’ EQUITY (DEFICIT)
Current liabilities:
Accounts payable $ 2,827 $ 1,931
Accrued expenses 1,510 1,207
Warrant liability — 88
Tranche liability 1,547 —
Other current liabilities 456 337
Total current liabilities 6,340 3,563
Warrant liability, non-current 162 283
Convertible Note, net 3,010 2,946
Operating lease liabilities, net of current portion 159 196
Total liabilities
9,671 6,988
TOTAL STOCKHOLDERS' EQUITY (DEFICIT)
17,628 (37)
TOTAL LIABILITIES AND STOCKHOLDERS’ EQUITY (DEFICIT) $ 27,299 $ 6,951
SERINA THERAPEUTICS, INC.
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
(in thousands, except per share data)
(Unaudited)
Three months ended March 31,
2026 2025
OPERATING EXPENSES
Research and development $ 3,199 $ 2,951
General and administrative 3,081 2,907
Total operating expenses 6,280 5,858
Loss from operations (6,280) (5,858)
OTHER (EXPENSE) INCOME, NET
Interest expense (189) —
Change in fair value of warrants 104 989
Change in fair value of tranche liability 1,030 —
Loss on extinguishment of financial commitment assets and contingent warrants, net
(1,616) —
Other income, net 60 47
Total other (expense) income, net (611) 1,036
Loss before income taxes (6,891) (4,822)
Provision for income taxes (7) —
NET LOSS (6,898) (4,822)
Net loss attributable to noncontrolling interest — 9
NET LOSS ATTRIBUTABLE TO SERINA $ (6,898) $ (4,813)
NET LOSS ATTRIBUTABLE TO SERINA COMMON STOCKHOLDERS $ (6,935) $ (4,813)
NET LOSS ATTRIBUTABLE TO SERINA COMMON SHAREHOLDER,
BASIC AND DILUTED $ (0.58) $ (0.49)
WEIGHTED-AVERAGE COMMON SHARES OUTSTANDING,
BASIC AND DILUTED 12,047 9,756
SERINA THERAPEUTICS, INC.
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
(in thousands)
(Unaudited)
Three months ended March 31,
2026 2025
Net cash used in operating activities $ (4,568) $ (4,322)
Net cash used in investing activities (25) —
Net cash provided by financing activities 26,057 4,917
Effect of foreign currency on cash and cash equivalents 6 —
NET CHANGE IN CASH AND CASH EQUIVALENTS 21,470 595
CASH AND CASH EQUIVALENTS:
At beginning of the quarter 3,056 3,672
At end of the quarter $ 24,526 $ 4,267
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