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Form 8-K

sec.gov
PALI The company entered into a master services agreement to assist with patient enrollment for a Phase 2 study and also sold shares in a private placement. The filing is a standard 8-K report and does not inherently indicate positive or negative performance.

8-K — PALISADE BIO, INC.

Accession: 0001493152-26-014822

Filed: 2026-04-02

Period: 2026-03-27

CIK: 0001357459

SIC: 2836 (BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES))

Item: Other Events

Documents

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UNITED

STATES

SECURITIES

AND EXCHANGE COMMISSION

WASHINGTON,

D.C. 20549

FORM

8-K

CURRENT

REPORT

Pursuant

to Section 13 or 15(d)

of

the Securities Exchange Act of 1934

Date

of Report (Date of earliest event reported): March 27, 2026

PALISADE

BIO, INC.

(Exact

name of Registrant as Specified in Its Charter)

Delaware

001-33672

52-2007292

(State

or Other Jurisdiction

of

Incorporation)

(Commission

File

Number)

(IRS

Employer

Identification

No.)

4600

South Syracuse Street

Suite

900

Denver,

Colorado

80237

(Address

of Principal Executive Offices)

(Zip

Code)

Registrant’s

telephone number, including area code: (858) 704-4900

N/A

(Former

name or former address, if changed since last report)

Check

the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under

any of the following provisions:

☐

Written

communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐

Soliciting

material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐

Pre-commencement

communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐

Pre-commencement

communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities

registered pursuant to Section 12(b) of the Act:

Title

of each class

Trading

Symbol(s)

Name

of each exchange on which registered

Common

Stock, par value $0.01 per share

PALI

Nasdaq

Capital Market

Indicate

by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405

of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging

growth company ☐

If

an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying

with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item

8.01. Other Events.

In

preparation for the expected Phase 2 study of PALI-2108 for the treatment of patients with moderate to severe Ulcerative Colitis (“UC”),

and in order to expedite the enrollment of patients (the “Study Enrollment”), on March 30, 2026, Palisade Bio, Inc. (the

“Company”) entered into a master services agreement (the “MSA”) with Iterative Scopes, Inc. d/b/a Iterative Health

(“IH”), pursuant to which IH has agreed to, among other things, assist the Company with the Study Enrollment.

On

March 27, 2026 (the “Closing Date”), the Company issued and sold 1,536,885 shares (the “Shares”) of common stock,

par value $0.01 per share (“Common Stock”), of the Company to an affiliate of IH (the “Investor”) for a total

purchase price of $3.0 million, or $1.952 per Share (which represents the average closing price of the Common Stock on the Nasdaq Capital

Market for the five trading days prior to the Closing Date), pursuant to a common stock purchase agreement, dated March 27, 2026, by

and between the Company and the Investor. The Shares were offered and sold in a transaction exempt from registration under the Securities

Act of 1933, as amended, in reliance on Section 4(a)(2) thereof.

Forward

Looking Statements

This

Current Report on Form 8-K contains “forward-looking” statements for purposes of the safe harbor provisions of the Private

Securities Litigation Reform Act of 1995. Forward-looking statements include statements regarding the Company’s intentions, beliefs,

projections, outlook, analyses or current expectations concerning, among other things, the Company’s plans for its Phase 2 clinical

study in UC and the enrollment of patients. These forward-looking statements are based upon the Company’s current expectations.

Forward-looking statements involve risks and uncertainties. Important factors that could cause actual results to differ materially from

those reflected in the Company’s forward-looking statements include, among others, the risks and uncertainties outlined in the

Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2025, filed with the SEC on March 20, 2026. These forward-looking

statements speak only as of the date hereof and the Company expressly disclaims any obligation or undertaking to release publicly any

updates or revisions to any forward-looking statements contained herein to reflect any change in the Company’s expectations with

regard thereto or any change in events, conditions or circumstances on which any such statements are based, except as required by law.

SIGNATURES

Pursuant

to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this Report on Form 8-K to be signed on its

behalf by the undersigned hereunto duly authorized.

Date:

April 2, 2026

Palisade

Bio, Inc.

/s/

J.D. Finley

By:

J.D.

Finley

Chief

Executive Officer

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Entity Central Index Key

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Entity Tax Identification Number

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Entity Incorporation, State or Country Code

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Entity Address, Address Line One

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Entity Address, Address Line Two

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Entity Address, City or Town

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Entity Address, Postal Zip Code

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City Area Code

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